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BioResearch

Image: The effects of p53 in cancer-associated fibroblasts on cancer cell migration: Cancer cells (magenta) migrate in the direction of cancer-associated fibroblasts (yellow) that express a non-mutated p53 gene (left); this migration slows down (center) when the p53 in the fibroblasts is silenced; when substances released by the cancer-associated fibroblasts are added to the laboratory dish, the migration is restored (right) (Photo courtesy of the Weizmann Institute of Science).

Conditions in the Tumor Microenvironment Change Role of p53

Cancer researchers have found that changes occurring in the tumor microenvironment manipulate the activity of fibroblast p53 protein, causing it to promote rather than restrict cancer growth. More...
09 Aug 2018
Image: A transmission electron micrograph (TEM) of norovirus particles in feces (Photo courtesy of Wikimedia Commons).

Norovirus Binding Requires Attachment to Fucose Residues

Norovirus, the most common cause of gastroenteritis worldwide, depends on binding to fucose molecules in order to attach to and invade cells in the human digestive tract. More...
09 Aug 2018
Image: Microcultures of oligocortical spheroids (Photo courtesy of Case Western Reserve University School of Medicine).

Stem Cell-Based Cultures Used for Brain Disease Research

A team of neurological disease researchers used stem cell technology to culture mini-organoids comprising all the major cell types found in the human cerebral cortex - including oligodendrocytes - for brain structure/function research. More...
08 Aug 2018
Image: Image shows the effect particles coated with phage (red) have on bacterial colonies (green). The dark green areas around the particles show areas where bacteria are being killed. (Photo courtesy of Rachit Agarwal, Garcia Laboratory, Georgia Institute of Technology).

Bacteriophages Delivered by Dry Powder Cure Lung Diseases in Model

A novel antibacterial transport system utilized a dry powder approach to deliver microparticles coated with bacteriophages to difficult to access areas in the lungs. More...
03 Aug 2018
Image: The mouse in the center photo shows aging-associated skin wrinkles and hair loss after two months of mitochondrial DNA depletion. That same mouse, right, shows reversal of wrinkles and hair loss one month later, after mitochondrial DNA replication was resumed. The mouse on the left is a normal control, for comparison (Photo courtesy of the University of Alabama).

Mitochondrial DNA Depletion Linked to Depletion Syndromes

Physiological deterioration due to depletion of mitochondrial DNA, such as markers of aging like wrinkled skin and hair loss, was shown to be reversed by restoration of normal mitochondrial DNA levels and function. More...
02 Aug 2018
Image: A representation of the molecular structure of PDHX protein (Photo courtesy of Wikimedia Commons).

Cancer Growth Promoted by an Oncogenic MicroRNA

Cancer researchers have discovered a critical molecular mechanism by which a specific microRNA promotes breast cancer growth through suppression of production of the enzyme PDHX (pyruvate dehydrogenase complex component X). More...
02 Aug 2018
Image: Combining a nanocarrier with antibodies under acidic conditions results in the antibodies attaching to the drug carrier in a stable way. This makes it possible for nanocarriers to target diseased tissue (Photo courtesy of Stefan Schuhmacher).

Adsorption Procedure Enhances Efficiency of Drug Transport

A simple adsorption procedure enhances the efficiency of nanocarrier transport of toxic drugs to tumors. More...
31 Jul 2018
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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