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BioResearch

Image: A model of the cytidine deaminase enzyme, which is a component of the single-base gene-editing system (Photo courtesy of Wikimedia Commons).

CRISPR Genome-Editing System Avoids DNA Strand Breaks

A variation of the CRISPR/Cas9 genome-editing tool enables more precise manipulation of target genes by not breaking double stranded DNA and instead modifying a single point in the targeted DNA sequence. More...
29 Aug 2018
Image: A photomicrograph of a mouse colon from Cyp1a reporter mice after feeding on a diet supplemented with indole-3-carbinol (I3C) (Photo courtesy of Chris Schiering, Francis Crick Institute).

Dietary Factors Limit Inflammation and Prevent Colon Cancer

A team of cancer researchers working with a mouse model has found that a chemical generated during digestion of vegetables such kale, cabbage, and broccoli activates a protein that helps maintain the integrity of the cells lining the gut – preventing chronic inflammation that has been implicated in the development of colon cancer. More...
28 Aug 2018
Image: Active enhancer RNAs (eRNAs) interact directly with BRD4, a protein linked to tumor development (Photo courtesy of the Lauberth laboratory, University of California, San Diego).

Novel Class of Enhancer RNAs Linked to Growth of Cancers

A recently described class of microRNA has been linked to the cancer-promoting activity of the mutated form of p53 protein. More...
27 Aug 2018
Image: A three-dimensional (3D) printed microfluidic probe. Cube-shaped and green-colored, this probe is about the size of a ring box; however, the design can be printed in many sizes (Photo courtesy of NYU Abu Dhabi).

Protocol Published for Manufacture of 3D-Printed Probes for Research

A detailed protocol for producing microfluidic probes (MFPs) by simple three-dimensional (3D) printing was evaluated and made public for the general research community. More...
23 Aug 2018
Image: With the new method, the researchers were able to image polyclonal antibody/HIV envelope complexes at a resolution of 4.7 angstroms. At this resolution, the researchers discovered that in rabbits, antibodies specific to a vulnerable site on HIV\'s outer glycan layer (blue shapes) are structurally highly convergent and closely resemble a previously isolated monoclonal antibody (green and teal ribbons) (Photo courtesy of Dr. Lars Hangartner, Scripps Research Institute).

Electron Microscopy Technique Boosts Development of Antibody-Based Vaccines

The novel use of an electron microscope imagining technique enabled vaccine developers to follow the design process of structure-based vaccines in real time. More...
22 Aug 2018
Image: A micrograph showing cellular senescence in human cells (Photo courtesy of Eva Latorre, University of Exeter).

Researchers Identify Two Proteins Required to Reverse Senescence

Two protein-splicing factors have been identified that enable mitochondria-targeted hydrogen sulfide to reverse senescence in endothelial cells. More...
21 Aug 2018
Image: In cells under duress, stress granules (in magenta) form outside of the nucleus (in blue). TDP-43 protein in green (arrow) that cannot bind to polyADP ribose (PAR) builds up in large clumps distinct from stress granules (Photo courtesy of Leeanne McGurk, University of Pennsylvania).

PARP-Inhibitors Reduce Damage in Some Neurological Disorders

A recent study found that blocking the activity of the poly(ADP-ribose)polymerase (PARP) family of enzymes reduced the amount of harmful TDP-43 (transactive response DNA binding protein) structures in brain cells under stress and slowed or prevented development of cytoplasmic inclusions found in neurological disorders such as amyotrophic lateral sclerosis (ALS), and some forms of frontotemporal degeneration (FTD). More...
20 Aug 2018
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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