Ibuprofen May Restore Immune Function in Older Individuals

New research suggests that macrophages from the lungs of old mice respond differently to infections than those of young mice, and ibuprofen given to the mice reversed these changes.

New research using lab mice suggests that the solution to more youthful immune function might already be a common over-the-counter pain reliever. In a report published in the September 2014 issue of the Journal of Leukocyte Biology, scientists revealed that macrophages from the lungs of old mice had different responses to Mycobacterium tuberculosis than macrophages from young mice, but these changes were reversed by ibuprofen.

“Inflammation in old age can have significant consequences on immune function,” said Joanne Turner, PhD, a researcher from the department of microbial infection and immunity and Center for Microbial Interface Biology at Ohio State University (Columbus, OH, USA). “With this knowledge, it may be possible to reduce or prevent some diseases in the elderly by decreasing inflammation with diet, exercise, and/or drugs.”

To uncover this mechanism, scientists measured inflammatory markers in the total lung or within purified macrophage populations of young healthy mice and of old healthy mice. Inflammatory markers were increased in old mice, and isolated macrophages from both old and young healthy mice responded differentially to infection with Mycobacterium tuberculosis in vitro. This suggests that the altered interactions with M. tuberculosis were linked to inflammation in old age. The researchers then administered an ibuprofen- supplemented diet to a group of old, but healthy, mice, and this reduced inflammation and restored immune function to that of young healthy mice.

“This may give new meaning to the phrase ‘take two aspirins and call me in the morning,’” said John Wherry, PhD, deputy editor of the Journal of Leukocyte Biology. “The report may not be about aspirin, but it does show that over-the-counter remedies may have broader value than usually appreciated, including affecting immune functions that change with age.”

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