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Advanced NMR Analysis Helps to Fine-tune Cell Culture Growth Conditions

By LabMedica International staff writers
Posted on 20 Jul 2011

Image: Cell culture media samples can be rapidly analyzed to provide unequivocal results (Photo courtesy of Claire England, Kapler Communications).

Image: Cell culture media samples can be rapidly analyzed to provide unequivocal results (Photo courtesy of Claire England, Kapler Communications).

Biotech researchers can optimize cell culture-growth conditions by sending samples of culture-growth media for sophisticated nuclear magnetic resonance (NMR) analysis that can identify metabolites that are consumed and beneficial or toxic products that are produced.

The “Spedia-NMR” NMR analysis service is provided by Spinnovation (Nijmegen, The Netherlands). The analysis service identifies a wide selection of feed components, metabolites, and toxic compounds in culture media. By comparing media profiles from different cell culture batches, Spedia-NMR identifies how a cell consumes and metabolizes the media along the culture process. Investigators usually receive results within five working days.

Spedia-NMR was designed to perform rapid, high throughput analyses of cell culture media batches and feed-batches in a very cost-efficient manner, using fully automated sample analysis and data processing. The technology - which has been successfully applied to cell types as varied as CHO (Chinese hamster ovary), stem cells, and virus production platforms - is available to all biotech investigators on a fee-for-sample basis or as a contract service.

Dr. Frederic Girard the CEO of Spinnovation said, “In the short term, Spedia-NMR will fill the gap in knowledge to strengthen and speed up cell-culture development and upstream processing… clients need to know what is going on in their cell culture and they need to know it fast. In the mid-term we will be able to provide methods and tools to our clients to help them to cope with the demand of FDA edicts regarding Quality by Design (QbD) and validation in the production environment.”

Related Links:
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