Animal-Free Insulin and Transferrin Growth Supplement Now Available

Investigators working with serum-free culture media are now able to obtain an animal-free media supplement that provides recombinant insulin and transferrin.

ITSE Animal-Free, manufactured by InVitria (Fort Collins, CO, USA), is a recombinant, animal-free media supplement used to improve cell performance. ITSE stands for insulin, transferrin, selenium, and ethanolamine, which are typically required for optimal cell growth in serum-free media.

Ethanolamine is a phospholipid precursor that improves the performance of cells in serum-free media and is required for the growth of some cell types. Insulin has cell-signaling functions and promotes the uptake of glucose and amino acids. Transferrin is a nontoxic carrier of iron and reduces the generation of toxic free-radicals and peroxide. Selenium is required for the activity of glutathione peroxidase, thioredoxin reductase, and other antioxidant enzymes.

The new ITSE supplement is provided as a sterile 100x liquid formula that users should find easy to use and cost-effective compared to other insulin or transferrin supplements, or serum.

"There are no other insulin-transferrin supplements on the market today that provide the confidence of using our completely animal-free, recombinant sources of insulin and transferrin", said Mary Ann Santos, product scientist at InVitria.

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