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BioResearch

cfDNA Testing Accurately Detects Fetal Trisomies in Twin Pregnancies

 Results presented in a recently published paper indicated that the performance of cfDNA (cell-free DNA) testing for trisomy 21 (Down syndrome) in twin pregnancy was similar to that reported in singleton pregnancy and was superior to that of the first‐trimester combined test or second‐trimester biochemical testing. More...
24 Jun 2019
Image: A representation of a methylated DNA molecule. The two white spheres represent methyl groups bound to two cytosine nucleotide molecules (Photo courtesy of Wikimedia Commons).

Disease-Related Epigenetic Variations Summarized in New DNA Methylation Atlas

A new DNA methylation atlas summarized a previously unexplored molecular level of human individuality called correlated regions of systemic interindividual variation (CoRSIVs), which may provide a resource for future population-based investigations into how interindividual epigenetic variation modulates risk of disease. More...
10 Jun 2019
Image: A new liquid biopsy test called DELFI (DNA evaluation of fragments for early interception) uses artificial intelligence to detect patients with cancer by identifying altered DNA fragmentation in the blood (Photo courtesy of Carolyn Hruban, Johns Hopkins University).

Machine Learning Approach Detects Cancer by Analyzing DNA in Blood Samples

Researchers have described a proof-of-principle approach for the screening, early detection, and monitoring of human cancer based on a machine learning approach that evaluates fragmentation patterns of cell-free DNA across the genome. More...
10 Jun 2019
Image: A micrograph showing retinal cells derived from a patient\'s skin cells, via induced pluripotent stem cells. The cells are organized in a polygonal shape and have taken on characteristic pigmentation (Photo courtesy of the University of California, San Diego).

Laboratory Model Reveals Genetic Risk Loci for AMD

Eye disease researchers used advanced stem cell technology to create a laboratory model of age-related macular degeneration (AMD), which enabled in-depth analysis of the genetics underlying the syndrome. More...
20 May 2019
Image: A micrograph showing four-cell stage mouse embryos (Photo courtesy of Kirill Makedonski, the Hebrew University of Jerusalem).

Gene Set Isolated in Transformation of Skin Cells into Embryonic Tissues

A team of developmental biologists identified a set of five genes that is capable of transforming skin cells into pluripotent stem cells and then into all three of the cell types that comprise the early embryo: the embryo itself, the placenta, and the extra-embryonic tissues, such as the umbilical cord. More...
13 May 2019
Image: A micrograph of a mucinous ovarian carcinoma (Photo courtesy of Wikimedia Commons).

Large GWAS Pinpoints Ovarian Cancer Risk Genes

Results of a large genome-wide association study identified 34 genes that are associated with an increased risk for developing the earliest stages of ovarian cancer. More...
13 May 2019
Image: A micrograph of a colonic biopsy showing inflammation of the large bowel in a case of inflammatory bowel disease (Photo courtesy of Wikimedia Commons).

Blood Test Distinguishes between Forms of Inflammatory Bowel Disease

A recently developed blood test distinguishes between mild and severe forms of inflammatory bowel disease and is potentially a step towards realizing personalized therapy for the syndrome. More...
13 May 2019
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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