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Hematology

Image: PAX5/CD103 dual immunohistochemistry (IHC) staining showing no definite dual-positive cells, PAX5 stain showing brown nuclear staining in nonneoplastic B cells and CD103 showing membranous and cytoplasmic staining in a subset of T cells (Photo courtesy of US National Institute of Cancer).

Dual Immunohistochemistry Bone Marrow Staining Detects Hairy Cell Leukemia

 Hairy cell leukemia (HCL) is a B-cell lymphoproliferative disorder characterized by distinct immunophenotype (positive for CD19, CD20, PAX5, CD22, CD11c, CD25, CD103, CD123, and CD200). Immunophenotypic analysis by flow cytometry (FC) is considered the gold standard for diagnosis of HCL. More...
03 Mar 2020
Image: Peripheral blood smear from a patient with myelodysplastic syndrome showing macrocytic and hyperchromic anemia (cross), hypersegmented neutrophil (arrow) and moderate thrombocytopenia (Photo courtesy of Jong-Hwa Kim, MD, PhD).

Leukemic Stem Cell Score Predicts Myelodysplastic Syndrome Prognosis

 Myelodysplastic syndromes (MDS) are clonal myeloid malignancies arising from hematopoietic stem cells (HSCs), which are characterized by bone marrow (BM) ineffective hematopoiesis, peripheral blood cytopenias, and a propensity to transform to acute myeloid leukemia (AML). More...
03 Mar 2020
Image: The VisuLize Factor XI ELISA Kit is an Enzyme Immunoassay for the quantitative determination of Factor XI Antigen in human plasma samples using the double antibody enzyme linked immuno-sorbent assay (ELISA) (Photo courtesy of Affinity Biologicals, Inc).

Factor IX Inhibitor Incidence in Pediatric Hemophilia B Examined

 Hemophilia B is a blood clotting disorder causing easy bruising and bleeding due to an inherited mutation of the gene for factor IX, and resulting in a deficiency of factor IX. It is less common than factor VIII deficiency (hemophilia A). More...
20 Feb 2020
Image: The BCS XP System is one of the most widely used fully automated hemostasis analyzers, delivers accurate and precise results (Photo courtesy of Siemens Healthcare).

Physical Activity and Thrombophilic Risk Investigated

 Among the effects of physical exercise on coagulation, the influence on protein anticoagulant system and PC deficiency-related thrombophilic risk are still controversial. The impact of physical activity on the coagulation system has been described. More...
18 Feb 2020
Image: The DOAC dipstick is a diagnostic urine test strip, which is intended for qualitative detection of the absence or presence of direct oral anticoagulants (DOACs: Dabigatran, Apixaban, Edoxaban and Rivaroxaban) in human urine by visual identification of colors (Photo courtesy of DOASENSE GmbH).

Direct Oral Anticoagulants Determined by RDT in Urine Samples

 The rapid determination of the presence of direct oral anticoagulants (DOACs) in a patient remains a major challenge in emergency medicine and for rapid medical treatment decisions. All DOACs are excreted into urine. More...
10 Feb 2020
Image: The BD FACSVerse Flow Cytometer (Photo courtesy of BD Biosciences).

Immune Profiles Analyzed in Acute Myeloid Leukemia Bone Marrow

 In acute myeloid leukemia (AML), myeloid lineage precursor cells modified by somatic mutations and transcriptomic dysregulation infiltrate the bone marrow (BM) and disrupt normal hematopoiesis. More...
03 Feb 2020
Image: Acute Myeloid Leukemia: The blasts are medium to large in size and have an elevated nuclear: cytoplasmic ratio. The nuclear chromatin is fine and there are prominent nucleoli. Frequent blasts show indented or “cup-shaped” nuclear contours (Photo courtesy of Elizabeth Courville, MD).

Bone Marrow Donors May Transfer Pathogenic Mutations to Patients

 Clonal hematopoiesis of indeterminate potential, or CHIP, is characterized by the presence of mutant hematopoietic stem cell clones in the bone marrow without overt signs of disease. More...
27 Jan 2020
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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