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Hematology

Image: The CS-2400 is a high performance coagulation station that allows laboratories to perform routine and specialized testing including platelet function tests (Photo courtesy of Sysmex).

Lupus Anticoagulant Prolongs Activated Partial-Thromboplastin Time in COVID-19

Patients with coronavirus disease 2019 (COVID-19) have a profound hypercoagulable state, and complicating venous thrombotic events are common. Abnormalities in coagulation screening measures, including a prolonged activated partial-thromboplastin time (aPTT), have been reported in patients with COVID-19. More...
20 May 2020
Image: Photomicrograph of multiple myeloma in a smear preparation of a bone marrow aspirate (Photo courtesy of the Institute of Cancer).

Immune Microenvironment Changes Contribute to Early-Stage Multiple Myeloma

Multiple myeloma is a cancer that forms in a type of white blood cell called a plasma cell. Plasma cells help you fight infections by making antibodies that recognize and attack germs. Multiple myeloma causes cancer cells to accumulate in the bone marrow, where they crowd out healthy blood cells. More...
14 May 2020
Image: The ACL Top 550 hemostasis analyzer (Photo courtesy of Werfen).

Blood Clotting Causes Significant Mortality in COVID-19 Patients

Although the underlying pulmonary pathophysiology remains incompletely understood, severe COVID-19 infection is associated with a marked alveolar inflammatory cell infiltrate, together with a systemic cytokine storm response. More...
11 May 2020
Image: Confocal microscope image of a hyperdiploid B-cell acute lymphoblastic leukemia (B-ALL) sample stained with tubulin (red), pericentrin (green), centromeres (purple) and DNA (blue) (Photo courtesy of Óscar Molina).

Physiological Mechanisms Underlying Prevalent Pediatric Leukemia Discovered

B-cell acute lymphoblastic leukemia (B-ALL) is characterized by the accumulation of abnormal immature B-cell precursors (BCP) in the bone marrow (BM) and is the most common pediatric cancer. More...
06 May 2020
Image: Diversity of peripheral blood human NK cells identified by single-cell RNA sequencing (Photo courtesy of University of Manchester).

Human NK Cells Identified by Single-Cell RNA Sequencing

Natural killer (NK) cells are cytotoxic lymphocytes that are crucial for viral defense as well as detecting and killing cancer cells. This cell type is therefore of great interest for cancer immunotherapy. More...
27 Apr 2020
Image: The Lymphoprep Tube is a sterile tube in that contains the Lymphoprep (separation medium) under a plastic filter disc. This is a simple and effective protocol most commonly used to isolate mononuclear cells (PBMCs) from human blood (Photo courtesy of Axis-Shield).

Functional Comparison of Different Tubes for Isolating Mononuclear Cells

Profiling of immune cells with single-cell technologies is a key component of both basic science studies, evaluation of therapeutics in clinical trials, and clinical care. Cryopreserved human peripheral blood mononuclear cells (PBMCs) are a commonly used sample type for a variety of immunological assays. More...
23 Apr 2020
Image: The XN-350 hematology analyzer and blood cell counter (Photograph courtesy of Sysmex).

Complete Blood Count Predicts Asymptomatic Preterm Birth

Preterm birth (PTB), defined as birth before 37 complete weeks of gestation, is a very serious obstetric problem worldwide. It affects 5% to 18% of all deliveries in the world and represents an enormous health care burden. More...
08 Apr 2020
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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