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Molecular Diagnostics

Image: The VERSANT HCV Genotype 2.0 Line Probe Assay (Photo courtesy of Siemens Healthcare Diagnostics).

Sequencing Methods for Hepatitis C Virus Genotyping Compared

Due to its high rate of mutation, hepatitis C virus (HCV) forms viral quasispecies, classified based on the highly variable regions in the envelope protein and nonstructural 5B protein (NS5B). As a result of this large genetic variability, seven genotypes and more than 67 subtypes have been identified. More...
04 Sep 2019
Image: Neurons from rat brain tissue stained green with antibody to ubiquitin C-terminal hydrolase L1 (UCH-L1), which highlights the cell body strong and the cell processes more weak. Astrocytes are stained in red with antibody to the GFAP protein found in cytoplasmic filaments. Nuclei of all cell types are stained blue with a DNA binding dye (Photo courtesy of Wikimedia Commons).

Concussive Injuries Diagnosed by Measuring a Brain Protein in Blood

A simple blood test detects brain injury by measuring the levels of two brain proteins, which are released into the circulation following head trauma. More...
02 Sep 2019
Image: A micrograph of a low malignant potential (LMP) mucinous ovarian tumor. The micrograph shows: Simple mucinous epithelium (right) and mucinous epithelium that pseudo-stratifies (left - diagnostic of a LMP tumor). Epithelium in a frond-like architecture is seen at the top of image (Photo courtesy of Wikimedia Commons).

Protein Biomarker Panel Enables Early Detection of Cancer

Analysis of biomarker expression data from serum obtained from ovarian cancer patients has enabled development of an early detection tool for epithelial ovarian cancer (EOC). More...
02 Sep 2019
Image: A simplified view of cellular metabolism (Photo courtesy of Wikimedia Commons).

Biomarker Panel Accurately Predicts Mortality Risk

Researchers on the topic of human aging used advanced metabolomic techniques to identify a panel of 14 biomarkers that was able to predict five- and 10-year mortality risk with a high degree of accuracy. More...
02 Sep 2019
Image: The gut-infecting bacterium Clostridium difficile shown growing in a petri dish, and is evolving into two separate species with one group highly adapted to spread in hospitals (Photo courtesy of Anne Koerber/LSHTM).

C. Difficile Bacteria Adapted to Spread in Hospitals

Clostridioides difficile, also known as Clostridium difficile, bacteria can infect the gut and are the leading cause of antibiotic-associated diarrhea worldwide. While someone is healthy and not taking antibiotics, millions of 'good' bacteria in the gut keep the C. difficile under control. More...
29 Aug 2019
Image: The CFX96 Touch RT-PCR detection system (Photo courtesy of Bio-Rad Laboratories).

Enterovirus Antibodies Detected in Acute Flaccid Myelitis Patients

Neurotropic enteroviruses (EVs), such as poliovirus, have long been associated with paralytic disease. Acute flaccid myelitis (AFM) has caused motor paralysis in more than 560 children in the United States since 2014. More...
28 Aug 2019
Image: Human pancreatic islet stained with glucagon antibody (red) and insulin antibody (blue). Glucagon is produced by alpha cells, while beta cells produce insulin (Photo courtesy of University of Turku).

Signature for Beta-Cell Autoimmunity Predicts Type 1 Diabetes

The appearance of Type 1 diabetes (T1D)-associated autoantibodies is the first and only measurable parameter to predict progression toward T1D in genetically susceptible individuals. More...
28 Aug 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.