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Molecular Diagnostics

Image: A micrograph of the superficial cerebral cortex showing neuron loss and reactive astrocytes in a person who has had a stroke (Photo courtesy of Wikimedia Commons).

Distinctive mRNA Signatures May Prove Diagnostic for Cancer-Related AIS

A recently published paper described a distinctive molecular signature present in blood mRNA expression profiles of patients with cancer-related acute ischemic stroke (AIS) that could potentially lead to earlier diagnosis of cancer in these patients. More...
22 Sep 2019
Image: The MagPlex Multiplexing Microspheres (Photo courtesy of Luminex).

Multiplex Microsphere Immunoassay Identifies Three Flavivirus Infections

The explosive spread of Zika virus (ZIKV) and associated complications in flavivirus-endemic regions underscore the need for sensitive and specific serodiagnostic tests to distinguish ZIKV, dengue virus (DENV) and other flavivirus infections. More...
19 Sep 2019
Image: The multigene germline panel test prospectively searches for pathogenic or likely pathogenic variants in 30 genes (Photo courtesy of Color Genomics).

Pathogenic Germline Variants Found in Breast Cancer Patients

There is still considerable debate on the value of multigene panel testing for inherited cancer in patients with breast cancer, based on both the prevalence of pathogenic/likely pathogenic (P/LP) variants and any therapeutic implications from genetic test results. More...
18 Sep 2019
Image: Islet of Langerhans from the pancreas of a patient with chronic Type 1 diabetes of 19 years duration. A single lobe of the pancreas was found to contain islets rich in residual beta cells (alpha cells in red; beta cells in green) (Photo courtesy of Diapedia).

Biomarker Identified for Early Beta-Cell Death in Type 1 Diabetes

Beta cells in the pancreas produce insulin and their death is a key feature of Type 1 diabetes, and that loss starts long before diagnosis. However, there has been no straightforward way to measure that early loss. More...
18 Sep 2019
Image: The Parsortix system for collection of circulating tumor cells (Photo courtesy of ANGLE plc).

Automated Collection of CTCs Improves Prostate Cancer Diagnosis

A recent paper described the benefits of circulating tumor cell (CTC) analysis for improving the diagnosis of aggressive prostate cancer beyond currently used PSA (prostate specific antigen) measurement, biopsy and/or MRI imagery. More...
16 Sep 2019
Image: Zika virus particles (red) shown in African green monkey kidney cells (Photo courtesy of the [U.S.] National Institute of Allergy and Infectious Diseases).

Zika Virus Test Kit Receives American Marketing Approval

A blood test designed to confirm diagnosis of Zika virus infection has been granted 510(k) marketing approval that allows it to be sold in the United States. More...
16 Sep 2019
Image: G-protein-coupled receptor mechanism (Photo courtesy of Wikimedia Commons).

Autoimmune Antibody Identified as Biomarker for Tachycardia Syndrome

Results published in a recent paper suggested that postural orthostatic tachycardia syndrome (POTS) was probably an autoimmune disorder and may boost the development of a simple blood test to diagnose the condition. More...
16 Sep 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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