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Molecular Diagnostics

Image: Color-enhanced scanning electron micrograph showing Salmonella typhimurium (red) invading cultured human cells (Photo courtesy of US National Institute of Allergy and Infectious Diseases).

Drug-Resistant Strains of Salmonella Causing Bloodstream Infections

Salmonella enterica subspecies enterica serovar Typhimurium (known as S. typhimurium) and other non-typhoidal Salmonella are common causes of gastrointestinal infections in people living in industrialized countries. More...
02 Oct 2019
Image: The use of RNA-seq as a decentralized methodology at the core of the MammaPrint and BluePrint microarray-based diagnostic technology (Photo courtesy of Agendia).

Targeted RNA Sequencing Technology Diagnoses Breast Cancer

In recent years, RNA-sequencing (RNA-seq) technology has become the standard for transcriptome analysis because of its flexibility, sensitivity, and accuracy in measuring gene expression. RNA-seq is a technology in which cDNA is derived from RNA, followed by library construction and massively parallel deep sequencing. More...
01 Oct 2019

New Guidelines Designed to Help Diagnose Chronic Diarrhea

A newly published official guideline for diagnosing chronic watery diarrhea was established to aid clinicians in choosing appropriate laboratory tests to exclude other diagnoses in the setting of suspected functional diarrhea or diarrhea-predominant irritable bowel syndrome (IBS-D). More...
30 Sep 2019
Image: This digitally colorized scanning electron microscopic (SEM) picture depicts four, yellow colored, Group A Streptococcus (GAS), Streptococcus pyogenes bacteria, which were atop the surface of a human white blood cell (WBC), known as a neutrophil (Photo courtesy of the US National Institute of Allergy and Infectious Diseases).

New Strain of Bacteria Causes Scarlet Fever

Scarlet fever is a classic exanthem of childhood caused by the bacterium Streptococcus pyogenes (group A streptococcus). Symptoms, which affect young children, include a high temperature, sore throat, and a pink-red rash that feels like sandpaper. More...
26 Sep 2019
Image: The ID Core XT BLOODchip is a molecular-based assay used in blood transfusion medicine to help determine blood compatibility and could supplement the classical blood match methodology (Photo courtesy of Progenika Biopharma SA).

Next-Gen Sequencing Matches Blood Group Antigens for Transfusion

Transfusion is the procedure of introducing donor material with unknown blood cell antigens into the recipient’s circulatory system. The recipient’s immune system recognizes foreign antigens, produces specific antibodies and sensitization (alloimmunization) occurs. More...
26 Sep 2019
Image: Breath analysis of lung cancer patients with the eNose device could identify patients who would or would not respond to immunotherapeutic treatment with 85% accuracy (Photo courtesy of Amsterdam University Medical Centers).

Breath Analysis Identifies Cancer Patients Likely to Benefit from Immunotherapy

An “electronic nose” analytical device has been developed that can determine the likelihood of a cancer patient to respond successfully to immunotherapy. More...
22 Sep 2019
Image: A micrograph of the superficial cerebral cortex showing neuron loss and reactive astrocytes in a person who has had a stroke (Photo courtesy of Wikimedia Commons).

Distinctive mRNA Signatures May Prove Diagnostic for Cancer-Related AIS

A recently published paper described a distinctive molecular signature present in blood mRNA expression profiles of patients with cancer-related acute ischemic stroke (AIS) that could potentially lead to earlier diagnosis of cancer in these patients. More...
22 Sep 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.