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Molecular Diagnostics

New Guidelines Designed to Help Diagnose Chronic Diarrhea

A newly published official guideline for diagnosing chronic watery diarrhea was established to aid clinicians in choosing appropriate laboratory tests to exclude other diagnoses in the setting of suspected functional diarrhea or diarrhea-predominant irritable bowel syndrome (IBS-D). More...
30 Sep 2019
Image: This digitally colorized scanning electron microscopic (SEM) picture depicts four, yellow colored, Group A Streptococcus (GAS), Streptococcus pyogenes bacteria, which were atop the surface of a human white blood cell (WBC), known as a neutrophil (Photo courtesy of the US National Institute of Allergy and Infectious Diseases).

New Strain of Bacteria Causes Scarlet Fever

Scarlet fever is a classic exanthem of childhood caused by the bacterium Streptococcus pyogenes (group A streptococcus). Symptoms, which affect young children, include a high temperature, sore throat, and a pink-red rash that feels like sandpaper. More...
26 Sep 2019
Image: The ID Core XT BLOODchip is a molecular-based assay used in blood transfusion medicine to help determine blood compatibility and could supplement the classical blood match methodology (Photo courtesy of Progenika Biopharma SA).

Next-Gen Sequencing Matches Blood Group Antigens for Transfusion

Transfusion is the procedure of introducing donor material with unknown blood cell antigens into the recipient’s circulatory system. The recipient’s immune system recognizes foreign antigens, produces specific antibodies and sensitization (alloimmunization) occurs. More...
26 Sep 2019
Image: Breath analysis of lung cancer patients with the eNose device could identify patients who would or would not respond to immunotherapeutic treatment with 85% accuracy (Photo courtesy of Amsterdam University Medical Centers).

Breath Analysis Identifies Cancer Patients Likely to Benefit from Immunotherapy

An “electronic nose” analytical device has been developed that can determine the likelihood of a cancer patient to respond successfully to immunotherapy. More...
22 Sep 2019
Image: A micrograph of the superficial cerebral cortex showing neuron loss and reactive astrocytes in a person who has had a stroke (Photo courtesy of Wikimedia Commons).

Distinctive mRNA Signatures May Prove Diagnostic for Cancer-Related AIS

A recently published paper described a distinctive molecular signature present in blood mRNA expression profiles of patients with cancer-related acute ischemic stroke (AIS) that could potentially lead to earlier diagnosis of cancer in these patients. More...
22 Sep 2019
Image: The MagPlex Multiplexing Microspheres (Photo courtesy of Luminex).

Multiplex Microsphere Immunoassay Identifies Three Flavivirus Infections

The explosive spread of Zika virus (ZIKV) and associated complications in flavivirus-endemic regions underscore the need for sensitive and specific serodiagnostic tests to distinguish ZIKV, dengue virus (DENV) and other flavivirus infections. More...
19 Sep 2019
Image: The multigene germline panel test prospectively searches for pathogenic or likely pathogenic variants in 30 genes (Photo courtesy of Color Genomics).

Pathogenic Germline Variants Found in Breast Cancer Patients

There is still considerable debate on the value of multigene panel testing for inherited cancer in patients with breast cancer, based on both the prevalence of pathogenic/likely pathogenic (P/LP) variants and any therapeutic implications from genetic test results. More...
18 Sep 2019
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