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Molecular Diagnostics

Image: Scanning electron photomicrograph (SEM) of breast cancer cells. Unselected, high-risk multigene testing for all patients with breast cancer is extremely cost-effective (Photo courtesy of Marie Thibault).

Multigene Testing for Breast Cancer Patients Proves Cost-Effective

Health systems in the UK and USA could cost-effectively screen all women with breast cancer for risky germline changes in a handful of breast or ovarian cancer genes, according to a new economic modeling analysis, identifying at-risk individuals who could benefit from additional imaging tests and cancer-reducing interventions. More...
16 Oct 2019
Image: A new blood test has been developed capable of detecting multiple cancer types. The new test looks for DNA, which cancer cells shed into the bloodstream when they die (Photo courtesy of weeksnews).

New Blood Test Capable of Detecting Multiple Cancer Types

A new blood test in development has shown ability to screen for numerous types of cancer with a high degree of accuracy, a trial of the test shows. In study, test proved able to detect and localize more than 20 types of cancer with a high degree of accuracy. More...
16 Oct 2019
Image: In acute myeloid leukemia (AML), defective blood cells (stained purple) are present. When the cells have a double mutation of both the IDH2 and SRSF2 genes (bottom right), the number of defective cells rises considerably, indicating a more lethal disease (Photo courtesy of Cold Spring Harbor Laboratory).

Two Different Mutations Identified as Cause of AML

Two very different mutations have been identified as unexpected partners in crime for causing the blood cancer acute myeloid leukemia (AML). Expert analysis helped reveal how this deadly duo is far more common in AML than thought. More...
15 Oct 2019
Image: A test to detect opioid drugs in exhaled breath was developed. In this photograph, a volunteer breathes normally into the human breath sampler. Samples are frozen before being taken to the laboratory for analysis (Photo courtesy of Dr. Cristina Davis, University of California, Davis).

Breath Analysis May Replace Blood Sampling to Monitor Drug Usage

A simple and non-invasive technique to collect exhaled breath condensate (EBC) from chronic pain patients was developed, and its usefulness was confirmed by comparing metabolites in breath and blood samples following use of different analgesic opioid drugs. More...
14 Oct 2019
Image: The Quant-iT PicoGreen dsDNA assay kit (Photo courtesy of Thermo Fisher Scientific).

Stunted Microbiota and Opportunistic Pathogen Colonize C-Section Birth

Immediately after birth, newborn babies experience rapid colonization by microorganisms from their mothers and the surrounding environment. Infants born by Caesarean section have gut microbiomes that differ from those of infants born vaginally, carrying more hospital-associated opportunistic pathogens. More...
10 Oct 2019
Image: A specific Parkinson’s gene mutation has been linked to a higher risk of leukemia and colon cancer (Photo courtesy of BioNews Services).

Parkinson’s Gene Mutation Linked to Higher Risk of Leukemia

Parkinson's disease is a progressive nervous system disorder that affects movement. Symptoms start gradually, sometimes starting with a barely noticeable tremor in just one hand. Tremors are common, but the disorder also commonly causes stiffness or slowing of movement. More...
10 Oct 2019
Image: The association of genetic liability to psychotic experiences with neuropsychotic disorders and traits has been explored (Photo courtesy of Cardiff University).

Genetic Links Uncovered Between Psychotic Experiences

Psychotic experiences, such as hallucinations and delusions, are features of psychiatric disorders, such as schizophrenia, but they are also reported by approximately 5% to 10% of the general population. More...
09 Oct 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.