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Molecular Diagnostics

Image: A nanopore device can contain different binding proteins. Once inside the pore, these proteins act as transducers to identify specific small molecules in a sample of body fluid (Photo courtesy of Dr. Giovanni Maglia, University of Groningen).

Detection System Used for Monitoring Small Molecules

A biological nanopore-based detection system can continuously monitor glucose and asparagine levels in microliter samples of blood, urine, saliva, or other body fluid in real-time. More...
15 Oct 2018
Image: The NextSeq 550 System brings the power of a high-throughput sequencing system to the benchtop (Photo courtesy of Illumina).

Antibiotic-Resistant Mutations Revealed by Sequencing Method

Antimicrobial resistance is on the rise and is responsible for millions of deaths every year. Bacterial populations consistently and rapidly overcome the challenge imposed by the use of a new antibiotic. More...
11 Oct 2018
DIASOURCE (A Biovendor Company)
Image: A scanning electron micrograph of dividing breast cancer cells (Photo courtesy of National Cancer Institute).

Disease-Associated Variants in Genes Allow Early Diagnosis

Sequencing the exomes of patients can identify breast cancer risk variants, even in patients without a family history of cancer or who otherwise would not be considered to be at an elevated risk. More...
10 Oct 2018
Image: Manhattan plot for meta-analysis (discovery) of GWAS of chronic back pain; Red line depicts genome-wide statistical significance; Blue line depicts suggestive significance (Photo courtesy of University of Washington).

New Gene Variants Associated with Chronic Back Pain

Back pain causes more years lived with disability than any other health condition worldwide. Although most adults experience a new (‘acute’) episode of back pain at some point in their lives, the societal burden of back pain is driven by the minority of individuals who fail to recover from such episodes and go on to develop persistent (‘chronic’) back pain (CBP). More...
09 Oct 2018
Image: The BD BACTEC MGIT automated mycobacterial detection system is a fully automated solution for mycobacterial liquid culture and susceptibility testing (Photo courtesy of Becton Dickinson).

TB Sequencing Could Replace Drug Susceptibility Testing

Tuberculosis (TB) is the most deadly infectious disease worldwide, causing 1.6 million deaths in 2017. Drug resistance is a particularly challenging and growing problem: as in 2017, it was estimated that 558,000 new cases of TB were resistant to rifampicin, the most effective first-line drug, and globally, just over half of patients with multi-drug resistant TB are successfully treated. More...
08 Oct 2018
Image: The SureSelectXT HS technology target enrichment system (Photo courtesy of Agilent Technologies.

Cancer Liquid Biopsy Assay Detects Low-Level Mutations

Circulating free DNA sequencing (cfDNA-Seq) can portray cancer genome landscapes, but highly sensitive and specific technologies are necessary to accurately detect mutations with variant frequencies that are often low. More...
08 Oct 2018
Image: The MinION is the only portable real-time device for DNA and RNA sequencing (Photo courtesy of Oxford Nanopore Technologies).

Pneumonia Diagnosed by Nanopore Sequencing of Sputum

Pathogen identification in patients with community-acquired pneumonia primarily relies on culture-based techniques. Sequencing-based approaches for pathogen identification are being applied to pneumonia patients. More...
04 Oct 2018
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