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Molecular Diagnostics

Image: A glioblastoma induced by the new gene-editing and screening technology (Photo courtesy Chen Lab, Yale University).

CRISPR Technology Identifies Cancer-Causing Genes

Researchers have identified specific gene combinations that can cause the brain cancer glioblastoma, using their newly developed modified CRISPR technology that can also pinpoint triggers and primary drivers of other types cancers. Thus the new technology could help improve diagnostics, as well as in finding more specific targets for developing more effective drugs. More...
22 Aug 2017

Liquid Biopsy Approach Inspired by Swarm Behavior

Researchers have designed an algorithm for blood sample analysis where, rather than testing for evidence of cancer DNA or protein biomarkers, they test for tumor cell RNA absorbed by circulating platelets – i.e. thrombocytes. In a new study, they designed the test to diagnose non-small cell lung cancers (NSCLCs), which make up the majority of lung cancer cases, and achieved ~90% accuracy on a validation control group. More...
21 Aug 2017
Image: A bioplasmonic paper-based device (BPD) for the detection of Zika virus (ZIKV) infection, via quantification of serum anti-ZIKV-nonstructural protein 1 (NS1) IgG and IgM (Photo courtesy of James Byard).

Biosensor Device Developed for Zika Diagnosis

A novel plasmonic biosensor-based detection system was developed that can diagnose recent or current Zika virus (ZIKV) infection in 15 minutes or less. More...
21 Aug 2017
Image: The Luminex 200 multiplex analyzer (Photo courtesy of Luminex Corporation).

Cytokine Concentration Linked to Chronic Fatigue Syndrome

More than one million people in the USA suffer from chronic fatigue syndrome, also known as myalgic encephomyelitis and designated by the acronym ME/CFS. It is a disease with no known cure or even reliably effective treatments. More...
16 Aug 2017
Image: A histopathology of adrenal pheochromocytoma from an adrenectomy specimen showing the characteristic stippled (finely granular) chromatin (Photo courtesy of Nephron).

Mutations Related to Hereditary Neuroendocrine Tumors

Pheochromocytomas and paragangliomas are rare neuroendocrine tumors with a strong hereditary component and half the genes whose alterations confer hereditary susceptibility to develop this condition code for enzymes involved in the Krebs cycle. More...
16 Aug 2017
Image: The model illustrates clinical implications of BCBM CTC screening method for brain micro-metastasis before they become detectable by MRI. BCBM-associated CTCs can be used as a tool to evaluate responses to therapy for BCBM patients (Photo courtesy of Houston Methodist).

Blood Test Detects Brain Metastases While Treatable

A blood test is being generated that can identify breast cancer patients who are at increased risk for developing brain metastasis, and also monitor disease progression and response to therapy in real time. More...
16 Aug 2017
Image: Brain scans from the study ‘Heterozygous de novo UBTF gain-of-function variant is associated with neurodegeneration in childhood’ (Photo courtesy of American Society of Human Genetics).

Neurological Disease Traced to Gene Error

A severe neurological rare disorder in children is characterized by developmental regression and neurodegeneration and at first the children lead normal lives and seem identical to their age-matched peers. More...
15 Aug 2017
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.