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Molecular Diagnostics

Image: The Epi ProColon screening test is a blood-based colorectal cancer screening test is an in vitro polymerase chain reaction assay for the qualitative detection of Septin9 gene methylation in DNA isolated from the patient’s plasma (Photo courtesy of Epigenomics).

Blood Test Complements Colonoscopy for Lynch Syndrome Patients

Lynch syndrome (LS) subjects are genetically predisposed to a high risk for colorectal cancer (CRC) and regular colonoscopy is currently the only CRC screening option recommended for these subjects, although compliance is suboptimal. More...
16 Jul 2019
Image: A scanning electron micrograph (SEM) of a human T-cell from the immune system of a healthy donor (Photo courtesy of [U.S.] NIAID).

Regulatory T-cell Responsiveness Predicts Risk of Cancer Relapse

The risk of future breast cancer relapse can be predicted by analyzing the signaling responsiveness of peripheral blood Treg II cells (CD45RA−FOXP3hi Treg cells) to immunosuppressive T helper type 1 (TH1) and T helper type 2 (TH2) cytokines. More...
15 Jul 2019
Image: A micrograph of a colonic biopsy showing inflammation of the large bowel in a case of inflammatory bowel disease (Photo courtesy of Wikimedia Commons).

Metabolomics Analysis Method Used for Diagnosis of IBD

A team of Canadian researchers used an advanced metabolomics approach to differentiate inflammatory bowel syndrome (IBS) from other related gastrointestinal disorders. More...
15 Jul 2019
Image: A diagram of how the X-Linked DDX3X RNA helicase dictates translation reprogramming and metastasis in melanoma (Photo courtesy of Lund University).

Protein Linked to Aggressive Skin Cancer

Almost 300,000 people worldwide develop malignant melanoma each year. The disease is the most serious form of skin cancer and the number of cases reported annually is increasing, making skin cancer one of Sweden's most common forms of cancer. More...
10 Jul 2019
Image: A histological preparation from a patient with invasive lobular carcinoma, demonstrating a predominantly lobular growth pattern (Photo courtesy of KGH).

Test Determines If Cancer Patients Require Chemotherapy

Invasive lobular carcinoma (ILC) is the most common special type of breast cancer, and is characterized by functional loss of E-cadherin, resulting in cellular adhesion defects. ILC typically present as estrogen receptor positive, grade 2 breast cancers, with a good short-term prognosis. More...
09 Jul 2019
Image: The cobas e 601 module for immunoassay tests (Photo courtesy of Roche Diagnostics).

Automated Approach Predicts Alzheimer's Disease Risk

An automated immunodiagnostic test predicts risk of developing Alzheimer's disease by measuring the level of beta-amyloid (Abeta) in the blood, which accurately reflects the accumulation of this protein in the brain. More...
08 Jul 2019
Image: A micrograph of the superficial cerebral cortex showing neuron loss and reactive astrocytes in a person that has had a stroke (Photo courtesy of Wikimedia Commons).

Levels of NfL Increase Accuracy of Stroke Risk Prediction

Serum levels of neurofilament light polypeptide have been found to predict the likelihood of suffering a stroke and to add considerably to the discriminatory power of the Framingham Stroke Risk Score in a group of middle-aged and older adults with diabetes mellitus. More...
08 Jul 2019
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