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Molecular Diagnostics

In this photomicrograph, the brown areas were stained for a biomarker in tissue from a patient who developed pancreatic cancer from a cyst (Photo courtesy of Dr. Koushik Das, Washington University).

Immunodiagnostic Test Predicts Progression of Pancreatic Cyst to Cancer

 By using an immunodiagnostic test to detect the Das-1 antibody biomarker in fluid from pancreatic cysts, researchers were able to identify those cysts that were likely to become cancerous with 95% accuracy. More...
17 Jun 2019
Image: The NimbleGen MS 200 CGH LOH microarray detection scanner (Photo courtesy of Roche).

Kidney Transplant Rejection Linked to New Mismatch Locus

Approximately 20% of the kidney waiting list in the USA consists of candidates whose allografts have failed. Acute rejection is one of the strongest predictors of decreased allograft survival. More...
13 Jun 2019
Image: The SLAN-96 real-time polymerase chain reaction (PCR) instrument (Photo courtesy of QuanDx/Zeesan Biotech).

Unexpected Prevalence of High-Risk HPV Types Demonstrated

Low- and middle-income countries have high incidences of cervical cancer linked to human papillomavirus (HPV), and without resources for cancer screenings these countries bear 85% of all cervical cancer cases. More...
13 Jun 2019
Image: The nCounter Max analysis system (Photo courtesy of NanoString Technologies).

Custom NanoString Assay Detects Bowel Cancer Subtypes

Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide. The median overall survival of metastatic (m)CRC patients with unresectable disease remains around 24 months with standard chemotherapies. More...
13 Jun 2019
Image: The SEQPRO LIPO IS assay is for the genetic diagnosis of familial hypercholesterolemia (Photo courtesy of Progenika Biopharma).

Genetic Familial Hypercholesterolemia Prevalent in Premature CVD

Premature coronary artery disease (CAD) is a major cause of mortality and morbidity. Increased low-density lipoprotein-cholesterol (LDL-C) level is a major risk factor for CAD and thus the main target for its prevention. More...
12 Jun 2019
Image: The PLATELIA ASPERGILLUS Ag Test (Photo courtesy of Bio-Rad Laboratories).

Invasive Pulmonary Aspergillosis Diagnosed by Molecular Test

Invasive aspergillosis (IA) is a common opportunistic fungal infection, mainly affecting patients with severe and prolonged neutropenia. Early diagnosis of invasive pulmonary aspergillosis (IPA) is notoriously difficult, but crucial for prompt treatment initiation required to improve patient outcome. More...
12 Jun 2019
Image: The cBot 2 System streamlines the sequencing workflow by automating cluster generation. It was a required accessory instrument for HiSeq sequencers (Photo courtesy of Illumina).

Sequencing Study Links DNA Alterations to Type 2 Diabetes

According to statistics from the World Health Organization, over 400 million people worldwide have diabetes. The vast majority of these cases are type 2 and diabetes is estimated to be the seventh leading cause of death globally. More...
06 Jun 2019
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