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Microbiology

Image: Photomicrograph of Rickettsia conorii in Vero cells (red rods; magnification ×1,000) (Photo courtesy of Wikimedia Commons)

Identification of Rickettsial Biomarker Facilitates Early Diagnosis of Tick-borne Spotted Fevers

 A protein biomarker has been identified that enables the rapid and specific early diagnosis of tick-borne rickettsial diseases such as Rocky Mountain spotted fever and Mediterranean spotted fever. More...
27 Jan 2020
Image: Photomicrograph of a sputum specimen showing the presence of numerous Mycobacterium tuberculosis bacteria (Photo courtesy of [U.S.] Centers for Disease Control and Prevention)

Genetic Biomarkers Detect Incipient Tuberculosis, Predict Progression of the Disease

 A panel of genetic biomarkers in samples of whole blood has been confirmed as a useful biomarker for the detection of incipient tuberculosis (TB). More...
27 Jan 2020
Image: Immunostaining of Helicobacter pylori infection in a gastric foveolar pit demonstrated in endoscopic gastric biopsy (Photo courtesy of KGH).

Helicobacter pylori Triggers Development of Stomach Disease

 Helicobacter pylori is a paradigm persistent pathogen colonizing about 50% of the human world population and represents a major risk factor for chronic gastritis, peptic ulceration and gastric malignancies. More...
23 Jan 2020
Image: PrimeStore Molecular Transport Medium (MTM) is the first molecular transport device designed to inactivate pathogens and stabilize both RNA and DNA for downstream molecular testing and characterization (Photo courtesy of Longhorn Vaccines and Diagnostics).

Mouth Swab Molecular Test for Tuberculosis Validated

 Clinical investigators are testing an approach being developed to diagnose tuberculosis using mouth swabs, which could become an alternate approach to sample collection methods currently used to do tuberculosis (TB) testing. More...
22 Jan 2020
Image: The BD Bactec FX40: the blood culturing instruments used with patented resin-containing media have shown higher rates of organism recovery, allowing for proper diagnosis and treatment of bloodstream infections (Photo courtesy of Becton, Dickinson and Company).

CSF Cytokine Characteristics Defined from Children with Meningitis

 Enteroviral meningitis (EVM) are the most common etiological agent for viral encephalitis, and are predominantly reported among children and always present as a milder clinical illness than other infectious causes which only need supportive therapy. More...
21 Jan 2020
Image: This micrograph depicts an atypical, enlarged lymphocyte found in the blood smear from a hantavirus pulmonary syndrome (HPS) patient. This large atypical lymphocyte is an example of one of the laboratory findings, which when combined with a bandemia, i.e., immature white blood cells, and dropping platelet count, is characteristic of HPS (Photo courtesy of Centers for Disease Control and Prevention)

Molecular Assays Developed for Hantavirus Pulmonary Syndrome

 Hantavirus Pulmonary Syndrome (HPS) is a serious and often fatal disease caused by viruses known as hantaviruses. These anthropozoonotic diseases comprising of two clinical entities: Hemorrhagic Fever with Renal Syndrome (HFRS), which occurs in the Old World, and Hantavirus Pulmonary Syndrome (HPS) in the New World. More...
16 Jan 2020
Image: The Karius Test, which uses microbial cell-free DNA (mcfDNA-seq), can predict bloodstream infections in leukemia patients up to three days before the onset of symptoms (Photo courtesy of Karius)

Blood-Based Sequencing Identifies Pediatric Cancer Infections Before Symptoms

 Infections are common, yet life-threatening complications that affect immuno-compromised cancer patients and bloodstream infection (BSI) is a common, life-threatening complication of treatment for cancer. More...
09 Jan 2020
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