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Immunology

Image: The ARCHITECT i2000SR immunoassay analyzer (Photo courtesy of Abbott).

Newly Developed Automated Immunoassay Analyzed

Dipeptidyl peptidase-4 (DPP-4) may be a suitable biomarker to identify people with severe asthma who have greater activation of the interleukin-13 (IL-13) pathway and may therefore benefit from IL-13-targeted treatments. More...
29 Nov 2017
Image: A diagram comparing the small intestine in Celiac disease with damaged villi and a normal bowel (Photo courtesy of the Mayo Clinic).

Novel Blood Test Differentiates Celiac from Gluten Sensitivity

The measurement of circulating cytokines in blood plasma within six hours of eating gluten differentiated patients with celiac disease from those with non-celiac gluten sensitivity. More...
24 Nov 2017
Image: The TK210 ELISA kit for the measurement of Thymidine Kinase by immunoassay (Photo courtesy of AroCell AB).

Immunoassay Quantifies Cancer Cell Loss During Treatment

The quantification of cell loss in breast cancer during neoadjuvant treatment (NACT) can be assessed by serum thymidine kinase protein concentrations (sTK1). TK1 has a key function in DNA synthesis and repair responsible for maintaining the nucleoid pool balance by salvage and recycle thymidine from extracellular sources. More...
21 Nov 2017
Image: Enzyme-linked immunosorbent assay (ELISA) kits for the measurement of fecal and serum zonulin (Photo courtesy of DRG International).

Fecal Zonulin Elevated in Crohn’s Disease and Smokers

Human zonulin is a protein that increases permeability in the epithelial layer of the small intestine by reversibly modulating the intercellular tight junctions. There is not sufficient information available about zonulin's participation in inflammatory bowel diseases (IBD). More...
20 Nov 2017
Image: A range of Elecsys and cobas Reagents for thyroid function test kits (Photo courtesy of Roche).

High Thyroid Hormone Levels Associated with Arterial Disease

Atherosclerosis is the process of progressive thickening and hardening of the walls of arteries from fat deposits on their inner lining. Atherosclerosis progresses insidiously from a subclinical condition to the clinical onset of vascular events to death. More...
15 Nov 2017
Image: A photomicrograph of a renal biopsy specimen suggesting acute tubular necrosis is the patchy or diffuse denudation of the renal tubular cells with loss of brush border (blue arrow) (Photo courtesy of the University of Alberta).

Autoimmune Disease Discovered Causes Kidney Failure

An insidious new autoimmune disease that causes kidney failure has been discovered. The condition causes a build-up of waste products in the blood and makes it difficult for kidneys to maintain adequate balance of fluid in the body. More...
15 Nov 2017
Image: An immunohistochemistry of PharmDX 22c3 staining of non-small-cell lung carcinoma (Photo courtesy of Agilent).

Assay Identifies Patients Benefiting from Cancer Immunotherapies

Programmed cell death ligand 1 (PD-L1) has been detected in up to 50% of all human cancers, and has become a major focus of therapeutic and biomarker studies. More...
14 Nov 2017
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.