We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

LabMedica

Download Mobile App
Recent News Expo Clinical Chem. Molecular Diagnostics Hematology Immunology Microbiology Pathology Technology Industry Focus

High Levels of Aldosterone Increase Risk of Diabetes

By LabMedica International staff writers
Posted on 19 Sep 2018
Increased levels of aldosterone, the main mineralocorticoid hormone, is already associated with hypertension, can play a significant role in the development of diabetes, particularly among certain racial groups.

Type 2 diabetes mellitus incidence has plateaued among non‐Hispanic whites (NHWs) but continues to rise among racial/ethnic minorities in the USA. Thus, novel preventive intervention targets are of paramount importance, one potential target is the renin‐angiotensin‐aldosterone (RAAS) system.

Image: The Vitros 5600 integrated system for blood analysis (Photo courtesy of Ortho Clinical Diagnostics).
Image: The Vitros 5600 integrated system for blood analysis (Photo courtesy of Ortho Clinical Diagnostics).

Scientists at the Ohio State University (Columbus, OH, USA) and their colleagues studied a population‐based sample of 6,814 men and women from four racial/ethnic groups: NHWs (38%), African Americans (28%), Chinese Americans (12%), and Hispanic Americans (22%). Participants were aged 45 to 84 years at baseline without evidence of clinical cardiovascular disease. The mean age was 64 ± 10 years and 51% were female.

Serum glucose was measured by rate reflectance spectrophotometry using thin film adaptation of the glucose oxidase method on the Vitros analyzer. Insulin was determined using a radioimmunoassay Linco Human Insulin Specific RIA Kit. The homeostasis model assessment (HOMA)‐2 of insulin resistance (HOMA2‐IR) and β‐cell function (HOMA2‐β) were calculated using the updated computer‐based HOMA index of insulin resistance (HOMA2‐IR) and computer‐based HOMA2‐β%. Aldosterone was measured using a competition‐based radioimmunoassay.

The team reported that there were 116 cases of incident diabetes mellitus over 10.5 years among 1,570 adults. A 100% increase in log‐aldosterone was associated with a 2.6 mg/dL higher fasting plasma glucose, 15% higher HOMA2‐IR and 6% higher HOMA2‐β. A 1‐SD increase in log‐aldosterone was associated with a 44% higher risk of incident diabetes mellitus with the greatest increase of 142% observed in Chinese Americans.

The authors concluded that aldosterone is associated with glucose homeostasis and diabetes mellitus risk with graded associations among Chinese Americans and African Americans, suggesting that pleiotropic effects of aldosterone may represent a modifiable mechanism in diabetes mellitus pathogenesis with potential racial/ethnic variation.

Joshua J. Joseph, MD, the lead investigator, said, “We know there’s a relationship between aldosterone and type 2 diabetes. Now we need to determine thresholds that will guide clinical care and the best medication for treatment.” The study was published on September 4, 2018, in the Journal of the American Heart Association.

Related Links:
Ohio State University


Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Specimen Collection & Transport
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
Gold Member
ADAMTS-13 Protease Activity Test
ATS-13 Activity Assay

Latest Immunology News

Testing Method Could Help More Patients Receive Right Cancer Treatment

Groundbreaking Test Monitors Radiation Therapy Toxicity in Cancer Patients

State-Of-The Art Techniques to Investigate Immune Response in Deadly Strep A Infections