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Molecular Diagnostics

Image: A close-up of the CRISPR-Chip device (Photo courtesy of Keck Graduate Institute).

Biosensor Device Uses CRISPR-Cas9 to Detect Target DNA Sequence

A team of biomedical engineers has developed and tested a graphene-based biosensor device that uses CRISPR/Cas9 technology to enable the digital detection of a target DNA sequence within intact genomic material. More...
01 Apr 2019
Image: Infinium arrays: microarrays are the ideal platform for assessing known markers in the human genome (Photo courtesy of Illumina).

Adverse Drug Response Risk Gene Identified for IBD

Investigators have uncovered genetic variants in a gene called Nudix hydrolase 15 (NUDT15) that seem to coincide with treatment-related complications in individuals of European ancestry with inflammatory bowel disease (IBD). More...
28 Mar 2019
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Image: A histopathology of hepatocellular carcinoma: a mononuclear inflammatory cell infiltrate extends from portal areas and disrupts the limiting plate of hepatocytes which are undergoing apoptosis, the so-called interface hepatitis of chronic active hepatitis. In this case, the hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (HBcAb) were positive (Photo courtesy of University of Utah Medical School).

Virus-Associated Liver Cancer Detected by Blood Tests

Viral infection with either hepatitis C virus (HCV) or Hepatitis B virus (HBV) is the chief cause of liver cancer in the world today, accounting for 80% of hepatocellular carcinoma (HCC). The viruses cause HCC because massive inflammation, fibrosis and eventual cirrhosis occurs within the liver. More...
27 Mar 2019
Image: Low levels of amyloid-beta and tau proteins in the vitreous humor were indicative of potential Alzheimer\'s disease risk (Photo courtesy of Wikimedia Commons).

AD Biomarkers in Ocular Fluid Indicate Dementia Risk

Measuring levels of amyloid-beta and tau proteins in the eye's vitreous humor has been suggested as means to detect dementia at an early stage in individuals at risk for Alzheimer's disease (AD). More...
25 Mar 2019
Image: An illustration of HLA-A complexed with HIV TAX peptide (Photo courtesy of Wikimedia Commons).

Reaction to Vancomycin Linked to Immune System HLA Variant

A simple and inexpensive assay for the HLA-A*32:01 genetic variant was developed for routine use in diagnostic laboratories to identify patients likely to suffer from vancomycin-associated drug rash with eosinophilia and systemic symptoms (DRESS). More...
25 Mar 2019
Image: The CFX96 real-time polymerase chain reaction detection system (Photo courtesy of Bio-Rad).

Fast Diagnosis of Sporotrichosis Based on RT-PCR

Sporotrichosis is a subacute or chronic infectious disease caused by dimorphic fungi of Sporothrix spp. The genus Sporothrix consists of several species with different geographic distributions, virulence, and antifungal susceptibilities, making species-level identification necessary. More...
21 Mar 2019
Image: A histopathology of clear cell papillary renal cell carcinoma (Photo courtesy of Nephron).

Five-Gene Signature Predicts Survival from Renal Cell Carcinoma

Papillary renal cell carcinomas include type 1 lesions, which are characterized by small cells in single layers and scanty cytoplasm and type 2 lesions, which are distinguished by larger cells, pseudo-stratified nuclei, and voluminous eosinophilic cytoplasm. More...
20 Mar 2019
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