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Molecular Diagnostics

Image: Human papilloma virus (HPV) encased in biofilms inside tonsil crypts (pictured) may explain why the roughly 5% of HPV-infected people who develop cancer of the mouth or throat are not protected by their immune systems. Tonsil crypts with HPV are shown in green; epithelial and biofilm layers are shown in red (Photo courtesy of Dr. Katherine Rieth, MD).

HPV Found Hidden on Surface of Tonsils

Human papilloma virus (HPV), the culprit behind cervical cancer and some forms of head and neck cancer may hide in small pockets on the surface of tonsils in people not known to carry the virus. More...
14 Feb 2018
Image: Immunohistochemistry of MLH-1 (M1) Mouse Monoclonal Primary Antibody which is used to qualitatively identify human DNA mismatch repair (MMR) protein MLH1, expressed in the nucleus of normal proliferating cells. Loss of MLH1 is associated with colorectal and other cancers (Photo courtesy of Roche Tissue Diagnostics).

Colorectal Cancer Immunohistochemistry Panel Launched

The global burden of colorectal cancer is expected to increase by 60% to more than 2.2 million new cases and 1.1 million deaths by 2030. Increasingly, guidelines are recommending universal screening of all newly diagnosed colorectal cancers for Lynch syndrome. More...
13 Feb 2018
Image: Diagram of how bacteria play a critical role in the development of colon cancer (Photo courtesy of Elizabeth Cook).

Bacteria Play Critical Role in Driving Colon Cancers

Patients with an inherited form of colon cancer harbor two bacterial species that collaborate to encourage development of the disease, and the same species have been found in people who develop a sporadic form of colon cancer. More...
12 Feb 2018
Image: The MinION is the only portable real-time device for DNA and RNA sequencing (Photo courtesy of Oxford Nanopore Technologies).

Residual Disease in Leukemia Patients Identified by ddPCR

Currently, minimal residual disease for chronic myeloid leukemia (CML) patients is typically monitored using real-time quantitative polymerase chain reaction (RT-qPCR), but often leukemic stem cells with the BCR-ABL1 rearrangement are present below the limit of detect of RT-qPCR. More...
08 Feb 2018
Image: Histopathology of Endometriosis of the Fallopian Tube (Luminal Pattern). In this pattern, the normal complex, folded tubal mucosa is replaced by flat columnar epithelium with a tin underpinning of specialized endometrial stroma. There are also blood cells in the lumen Photo courtesy of Dr. Ed Uthman).

Genetic Biomarkers Determine Risk of Developing Endometriosis

Endometriosis is one of the most common women's health disorders, causing up to 10% of reproductive-age women to experience painful periods and potential infertility. Diagnosis can elude patients for decades, in part because exploratory surgery is considered the ultimate diagnostic method. More...
07 Feb 2018
Image: (A) Histology of a case of olfactory neuroblastoma with upregulation of CD24 gene by microarray, (B) confirmed by CD24 protein overexpression in the tumor cells (Photo courtesy of Caris Life Sciences).

Analysis Offers Treatment Options for Olfactory Neuroblastoma

Olfactory neuroblastoma (ONB) is a rare, locally aggressive, malignant neoplasm originating in the olfactory epithelium in the nasal vault. The recurrence rate of ONB remains high and there are no specific treatment guidelines for recurrent/metastatic ONBs. More...
01 Feb 2018
Image: Histopathology: (D) H&E staining showing the trabecular pattern of MAFA mutation-positive insulinomas. (E) Immunostaining shows diffuse MAFA expression in the tumor, at lower levels compared with the neighboring normal islets strongly expressing MAFA (Inset) (Photo courtesy of the Queen Mary University of London).

Mutation Found in Families with Contradictory Blood Sugars

Insulinomatosis is a condition characterized by the occurrence of multicentric insulinomas, pancreatic neuroendocrine tumors with β-cell–like features causing hyperinsulinemic hypoglycemia. More...
01 Feb 2018
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