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Molecular Diagnostics

Image: Micrograph of an intrahepatic cholangiocarcinoma (right of image) adjacent to normal liver cells (left of image). (Photo courtesy of Wikimedia Commons)

Mutations Causing Loss of Tumor Suppressor Gene Increase Aggressiveness of Rare Bile Duct Cancer

 A team of Japanese cancer researchers identified a biomarker, that when absent or reduced, predicts the likely outcome of the rare cancer of the bile duct, intrahepatic cholangiocarcinoma (ICC). More...
17 Dec 2019
Image: Histopathology of Wilms tumor or nephroblastoma which is a type of kidney cancer that is seen predominantly in children (Photo courtesy of Nephron).

Childhood Kidney Cancer Arises from Altered Normal Tissue

 While kidney cancer in children is rare, the most common type is Wilms tumor, which mostly affects children under the age of five. Most cases of Wilms tumor can be cured through surgery to remove the afflicted kidney in combination with chemotherapy and possibly radiotherapy. More...
16 Dec 2019
Image: Representation of the structure of human serum albumin, the most abundant protein in human blood plasma (Photo courtesy of Wikimedia Commons)

Predicting Age by Profiling Circulating Plasma Proteins

 It has been shown to be possible to calculate the age of an individual by measuring levels of various proteins circulating in the blood plasma. More...
16 Dec 2019
Image: Scanning electron micrograph of carbapenem-resistant Enterobacteriaceae bacteria (Photo courtesy of Stephanie Rossow, Centers for Disease Control and Prevention/Antibiotic Resistance Coordination & Strategy Unit)

A Rapid Method for Selecting the Proper Antibiotic to Treat Multidrug Resistant Bacteria

 A new diagnostic approach allows physicians to accurately identify bacterial pathogens and identify the most appropriate antibiotic within a period of hours rather than days. More...
12 Dec 2019
Image: Trypanosoma cruzi amastigotes in heart tissue from a patient with Chagas disease (Photo courtesy of the CDC)

Chronic Comorbidities Are Prevalent Among People with Chagas Disease

 Chagas disease, also known as American trypanosomiasis, is a tropical parasitic disease caused by the protist Trypanosoma cruzi. It is spread mostly by insects known as Triatominae, or "kissing bugs". The symptoms change over the course of the infection. More...
12 Dec 2019
Image: Biopsy of small bowel showing celiac disease manifested by blunting of villi, crypt hypertrophy, and lymphocyte infiltration of crypts (Photo courtesy of Wikimedia Commons)

A One-step Rapid Point-of-Care Assay for Diagnosis of Celiac Disease

 A spectrophotometric assay has been developed that shows strong potential for use as a point-of-care (POC) assay for the rapid detection of celiac disease antibodies. More...
12 Dec 2019
Image: The ARCHITECT Anti-HCV assay is a fully automated high throughput chemiluminescent microparticle immunoassay (CMIA) for the detection of antibodies to structural and nonstructural proteins of the hepatitis C virus (HCV) (Photo courtesy of Abbot Diagnostics)

Diagnosis and Monitoring of Patients with Hepatitis C Virus

 The global prevalence of people with hepatitis C virus (HCV) antibodies (anti-HCV-positive) is estimated to be 115 million, and 80 million of them have an active infection (anti-HCV-positive and HCV-RNA-positive). More...
11 Dec 2019
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