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Molecular Diagnostics

Image: Micrograph of gold nanostar biosensors used to detect cancer-related microRNAs (Photo courtesy of Duke University School of Engineering)

Nanostar Biosensors Use Raman Scattering for Direct Detection of Cancer-Related MicroRNAs

A novel non-invasive nanoparticle-based assay detects cancer-related microRNAs without use of labels or target amplification. More...
03 Aug 2020
Image: The benchtop SH800S cell sorter permits sorting of a wide range of cell sizes for many applications using the 70-μm, 100-μm, and 130-μm microfluidic sorting chips (Photo courtesy of Sony Biotechnology).

Pediatric Ependymoma Single-Cell Analysis Signatures Linked to Outcomes

An ependymoma is a tumor that arises from the ependyma, a tissue of the central nervous system. Usually, in pediatric cases the location is intracranial, while in adults it is spinal. The common location of intracranial ependymomas is the fourth ventricle. More...
30 Jul 2020
Image: There is currently no standard diagnostic tool or method for the early detection of pancreatic cancer. A test that is sensitive and specific enough to detect pancreatic cancer in its earliest stages has the potential of saving many lives (Photo courtesy of Immunovia AB)

Combined Proteomic/Genomic Method Detects Early Signs of Pancreatic Cancer

A new method that utilized a combined proteomic and genomic approach for profiling serum proteins in solution demonstrated high accuracy for distinguishing samples derived from pancreatic cancer patients and those from healthy controls. More...
29 Jul 2020
Image: Immune events leading up to a rheumatoid arthritis flare (Photo courtesy of Dr. Dana Orange, Rockefeller University)

RNA Sequencing Identifies Novel Cell Class Linked to Rheumatoid Arthritis Flares

A novel class of blood cells has been identified, which may serve as a biomarker able to predict the imminent occurrence of an episodic “flare” in patients with rheumatoid arthritis. More...
28 Jul 2020
Image: Micro Mass Quattro Premier Mass Spectrometer (Photo courtesy of University of Massachusetts Amherst).

Plasma Lipidome Investigated in Hereditary Hemochromatosis

Hereditary hemochromatosis (HH) is an autosomal recessive genetic disorder with increased intestinal iron absorption which leads to iron overload and consequently to tissue damage and functional impairment of organs like liver, pancreas, and heart. More...
28 Jul 2020
Image: FoundationOne liquid biopsy assays were used to study the association of circulating tumor DNA and circulating tumor cells after neoadjuvant chemotherapy with disease recurrence in patients with triple-negative breast cancer (Photo courtesy of Foundation Medicine).

Circulating Tumor DNA Associated with Triple-Negative Breast Cancer Recurrence

Patients with early-stage triple-negative breast cancer (TNBC) are frequently treated with neoadjuvant chemotherapy, based on the increased risk for recurrence and death associated with this category of tumors. More...
27 Jul 2020
Image: The RaDaR (Residual Disease and Recurrence) assay detects circulating tumor DNA (ctDNA) found in the bloodstream (Photo courtesy of Inivata).

CtDNA Assay for Cancer Recurrence, MRD Applications Demonstrated

Circulating tumor DNA (ctDNA) is found in the bloodstream and refers to DNA that comes from cancerous cells and tumors. Most DNA is inside a cell's nucleus. As a tumor grows, cells die and are replaced by new ones. The dead cells get broken down and their contents, including DNA, are released into the bloodstream. More...
22 Jul 2020
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