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Molecular Diagnostics

Image: The fully automated Idylla EGFR Mutation Test covers 51 mutations in exons 18–21 in a single cartridge using only one FFPE tissue section from metastatic non-small cell lung cancer (NSCLC) showing a high concordance of >95% compared with reference methods (Photo courtesy of Biocartis).

EGFR Mutation Assay Cartridges Evaluated

 Lung cancer remains the leading cause of cancer deaths. The management of lung cancer has been aided by the better understanding of molecular mechanisms involved in its initiation and progression and increased usage of molecular testing. More...
24 Mar 2020
Image: Histopathological image of multiple myeloma from a bone marrow aspirate (Photo courtesy of Wikimedia Commons)

Combination of Genetic Signatures Identifies Ultra High Risk Multiple Myelomas

 Combining two panels of genetic biomarkers enabled cancer researchers to identify multiple myeloma patients at “ultra high risk” of progression of the disease and probable lack of response to lenalidomide, the primary drug used to treat it. More...
24 Mar 2020
Image: SARS-CoV-2 has been detected in different types of clinical specimens (Photo courtesy of New York State).

SARS-CoV-2 Detected in Multiple Sample Types

 An epidemic of respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in China and has spread to other countries. Real-time reverse transcriptase–polymerase chain reaction (rRT-PCR) of nasopharyngeal swabs typically has been used to confirm the clinical diagnosis. More...
23 Mar 2020
Image: Scanning electron micrograph of a human T-cell (Photo courtesy of Wikimedia Commons)

T-cell Monitoring to Predict Risk of Kidney Transplant Failure

 A recently published paper discussed the potential application of CD8+ memory T-cell monitoring to improve risk prediction for kidney transplant failure. More...
23 Mar 2020
Image: The Agilent 4200 TapeStation system is an established automated electrophoresis tool for DNA and RNA sample quality control (Photo courtesy of Agilent Technologies).

NGS Identifies Genomic Characteristics of Pediatric Leukemia

 Pediatric leukemias have a diverse genomic landscape associated with complex structural variants, including gene fusions, insertions and deletions, and single nucleotide variants. Routine karyotype and fluorescence in situ hybridization (FISH) techniques lack sensitivity for smaller genomic alternations. More...
19 Mar 2020
Image: Micrograph of prostate adenocarcinoma, acinar type, the most common type of prostate cancer (Photo courtesy of Wikimedia Commons)

Methylome Analysis for Noninvasive Prostate Cancer Monitoring

 Researchers have demonstrated the potential of methylation analysis of circulating tumor DNA (ctDNA) for the noninvasive diagnosis of prostate cancer. More...
19 Mar 2020
Image: Micrograph showing a prostate cancer (conventional adenocarcinoma) with perineural invasion (Photo courtesy of Wikimedia Commons)

Advanced Urinary Analysis Method Expected to Significantly Reduce Number of Prostate Cancer Biopsies

 A team of British researchers has developed an advanced, RNA and DNA biomarker-based urine test for diagnosis of prostate cancer, which is expected to significantly reduce the number of unnecessary biopsies performed every year. More...
18 Mar 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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