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Molecular Diagnostics

Image: Illustration depicting tumor formation in the tissues of the oropharynx (Photo courtesy of Wikimedia Commons)

MicroRNA-Based Liquid Biopsy Assay for Early Diagnosis of Head and Neck Cancer

A microRNA-based liquid biopsy assay has been developed that enables early diagnosis of oropharyngeal squamous cell carcinoma, a disease causing hundreds of thousands of fatalities each year. More...
09 Sep 2020
Image: Cancer cells sometimes evade the body`s immune system by switching off T- cell`s anticancer protection; immunotherapy blocks this, but does not work in all patients (Photo courtesy of University of Bath)

New Diagnostic Test Assesses Suitability for Immune Checkpoint Inhibitor Immunotherapy

A newly developed diagnostic procedure enables doctors to predict whether a cancer patient will benefit from immune checkpoint inhibitor immunotherapy. More...
08 Sep 2020
Image: Visualization of Loopamp Trypanosoma cruzi results by the naked eye, Tubes 1 (Negative control) and 5 were negative, but #5 was positive on qPCR with a very low DNA load (Photo courtesy of Laboratorio de Biología Molecular de la Enfermedad de Chagas).

Loop-Mediated Isothermal Amplification Kit Detects Chagas Disease

Chagas disease (CD), also known as American trypanosomiasis, is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi that affects about six to seven million people worldwide, mainly in endemic areas of 21 Latin American countries. More...
07 Sep 2020
Image: A mobile phone app called HandLens was designed to read and report paper strip SHERLOCK results (Photo courtesy of Anna Lachenauer, Stanford University School of Medicine)

Rapid CRISPR/Cas Assay for Diagnosis of Viral Fevers in Low-Tech Environments

Rapid diagnostic tests for Ebola and Lassa fever viruses based on the RNA-targeting CRISPR/Cas13a complex have been tested successfully under field conditions in several African countries. More...
07 Sep 2020
Image: Higher prevalence of clonal hematopoiesis found in the blood and bone marrow of older healthy volunteers (Photo courtesy of Sorbonne University).

Clonal Hematopoiesis Prevalence Determined in Healthy Donors

Clonal hematopoiesis of indeterminate potential (CHIP) is defined as the presence of a clone at more than 2% of variant allele frequency (VAF) in peripheral blood (PB) of individuals with no evidence of hematologic disease. More...
02 Sep 2020
Image: A magnified image captured by the device used to perform the STAR (single telomere absolute-length rapid) assay. Different fluorescent intensities reflect the length variations in individual telomere molecules (Photo courtesy of National University of Singapore).

Streamlined Method for Telomere Length Measurement Opens New Cancer Diagnostic Opportunities

In a novel approach to cancer diagnosis, researchers have developed a high-throughput digital real-time PCR method for rapidly measuring the absolute lengths and quantities of individual telomere molecules. More...
01 Sep 2020
Image: Scanning electron micrograph of inside the nucleus of a cancer cell, chromosomes are indicated by blue arrows and circular extrachromosomal DNA are indicated by orange arrows (Photo courtesy of Paul S. Mischel, MD, UC San Diego).

Pan-Cancer Study Reveals Extrachromosomal DNA Frequency

Extrachromosomal circular DNA (eccDNA) are circular DNA found in human, plant and animal cells in addition to chromosomal DNA. eccDNA originate from chromosomal DNA and can be from 50 base pairs to several mega-base pairs in length and encode regulatory elements and several full genes. More...
01 Sep 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.