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Molecular Diagnostics

Image: Scientists have greatly boosted the amount of information that can be obtained using Seq-Well S3, a technique for rapidly sequencing RNA from single cells (Photo courtesy of MIT).

Novel Method Reclaims Resolution of Single-Cell RNA-Seq

Single-cell RNA sequencing (scRNA-seq) is a powerful tool to characterize cells. Current scRNA-seq platforms, despite offering high throughput, are inefficient and provide low resolution among distinct cell states and molecular features. More...
28 Oct 2020
Image: A recently developed electrochemical bio‐barcode device paired with a smartphone enables cancer patients to read critical biomarker levels at home in samples of self-drawn blood (Photo courtesy of Georgia Kirkos, McMaster University)

An Electrochemical Bio-barcode Device for Home Disease Monitoring and Diagnosis

A point-of-care (POC) electrochemical bio‐barcode device and assay system have been developed to enable analysis of protein biomarkers in undiluted and unprocessed human plasma samples. More...
28 Oct 2020
Image: A sample collection kit for the expanded Multi-Cancer 83-gene comprehensive panel that increases diagnostic yield. Germline testing after tumor sequencing uncovers clinically actionable variants (Photo courtesy of Invitae).

Germline Testing After Tumor Sequencing Uncovers Clinically Actionable Variants

Genetic counseling and germline testing are recommended for patients with cancer who have suspected hereditary disease based on each patient’s presentation and family history. Separately, tumor DNA sequencing is increasingly used, most often in patients with advanced disease. More...
27 Oct 2020
Image: Digital droplet PCR (ddPCR): schematic showing oil droplets containing fluorescent PCR target molecules (Photo courtesy of Wikimedia Commons)

A Novel Liquid Biopsy Technique for Brain Tumor Diagnosis

A minimally invasive liquid biopsy technique enables diagnosis of glioma, the most common type of brain tumor, by PCR analysis of an easily obtained blood plasma sample. More...
27 Oct 2020
Image: Circulating tumor cells (CTCs) are cancer cells that are released and disseminated into the bloodstream and lymphatic system. CTC cultures were successfully propagated from breast epithelial cells (Photo courtesy of Menarini Silicon Biosystems).

Novel CTC Culture Method Developed to Study Metastatic Cancer

Cancer metastasis is responsible for most cancer-associated death. During metastasis, cells that escape the primary tumor into the circulatory system are known as circulating tumor cells (CTCs). More...
26 Oct 2020
Image: Pro-inflammatory IL-6 is responsible for stimulating acute phase protein synthesis, as well as the production of neutrophils in the bone marrow. It supports the growth of B-cells and is antagonistic to regulatory T-cells (Photo courtesy of Wikimedia Commons)

The Dublin-Boston Scoring System Predicts Severity of COVID-19 Infections

A newly devised scoring system was designed to help doctors identify COVID-19 patients more likely to develop severe infections with potentially life-threatening complications. More...
26 Oct 2020
Image: Photomicrograph of histology of a Ewing sarcoma in lung. The PAS stain highlights glycogen and the staining was negative with a PAS diastase stain (Photo courtesy of Nephron).

Comprehensive Molecular Profiling Matches Pediatric Patients to Therapies

A major challenge of using a comprehensive profiling approach for precision medicine is separating pathogenic from non-pathogenic molecular changes within a tumor. More...
22 Oct 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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