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Molecular Diagnostics

Image: Identification of RNA-based gene fusions and splicing variants, enables detection of known and novel gene fusions. Gene fusions and splicing variants have been recognized as tumor drivers, providing new targets for personalized therapy (Photo courtesy of Predicine)

Combined DNA/RNA Liquid Biopsy Test Identifies Genetic Aberrations in Metastatic Prostate Cancer

Analysis of cell-free DNA and RNA in liquid biopsy samples revealed aberrations in the gene coding for the androgen receptor (AR), which were related to effectiveness of drug treatment and survival time in patients with castration-resistant prostate cancer (mCRPC). More...
14 Jul 2020
Image: The Oncotype DX Genomic Prostate Score (GPS) test is a strong independent predictor of prostate cancer-specific death and disease progression (metastases) at 10 years in men with localized prostate cancer (Photo courtesy of Genomic Health).

Gene Genomic Prostate Score Test Evaluated as Prognosis Predictor

Molecular assays, including multi-gene expression assays, are increasingly used clinically to improve risk stratification for men with newly diagnosed prostate cancer (PCa). More...
13 Jul 2020
Image: RNA from all bodily organs is present in the blood and can be used to detect pregnancy complications (Photo courtesy of Illumina).

Early-Onset Preeclampsia Risk Reflected in Circulating Maternal Transcripts

Preeclampsia is a poorly understood pregnancy-associated disorder. Often marked by hypertension, preeclampsia can lead to severe complications including internal bleeding, seizures, stroke, premature birth, and death. More...
13 Jul 2020
Image: The Idylla system is a fully-automated, real-time polymerase chain reaction (PCR) based molecular testing system designed to offer results in a minimal amount of time (Photo courtesy of Biocartis).

Rapid Genomic Profiling of Colon Cancers Improves Therapy Selection

Colorectal cancer is a malignant tumor arising from the inner wall of the large intestine (colon) or rectum. Colorectal cancer is the third leading cause of cancer in both men and women in the USA. Most colorectal cancers develop from polyps. Removal of colon polyps can aid in the prevention of colorectal cancer. More...
09 Jul 2020
Image: Illustration depicts a healthy liver (left) and a liver with cirrhosis (Photo courtesy of [U.S.] National Institute of Diabetes and Digestive and Kidney Diseases)

Gut Microbiome Metabolomic Profiles Are Diagnostic for Liver Diseases

Liver disease researchers have developed a noninvasive method to diagnose nonalcoholic fatty liver disease (NAFLD) and predict progression to cirrhosis by analyzing metabolomic profiles produced by the microorganisms living in the gut (the microbiome). More...
08 Jul 2020
Image: Single-cell copy number profiling: Chromium Single Cell CNV Solution provides a comprehensive, scalable solution for revealing genome heterogeneity and understanding clonal evolution (Photo courtesy of 10X Genomics).

DNA Sequencing Technique Unravels Genetic Diversity of Cancer Tumors

The ability to sequence the genome of a tumor has revolutionized cancer treatment by identifying drivers of cancer at the molecular level. However, understanding the genetic diversity of individual cells within a tumor and how that might impact the disease progression has remained a challenge, due to the current limitations of genomic sequencing. More...
07 Jul 2020
Image: Typical or `classical` ALS involves neurons in the brain (upper motor neurons) and in the spinal cord (lower motor neurons) (Photo courtesy of Wikimedia Commons)

An Eight MicroRNA Biomarker Panel for Diagnosis of ALS

A team of neurodegenerative disease researchers has identified eight microRNA sequences from enriched exosome extractions of blood plasma that consistently and significantly differentiate patients with amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) from healthy controls. More...
07 Jul 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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