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Molecular Diagnostics

Image: A smartphone camera is an important component of a new assay system for the detection of E. coli in urine samples (Photo courtesy of University of Bath)

Rapid UTI Test System Combines an Immunoassay with a Smartphone Camera

 A team of British bioengineers has combined a rapid microfluidic fluorescence sandwich immunoassay with a smartphone camera to form an assay system for the diagnosis of urinary tract infections (UTIs). More...
22 Jan 2020
Image: PrimeStore Molecular Transport Medium (MTM) is the first molecular transport device designed to inactivate pathogens and stabilize both RNA and DNA for downstream molecular testing and characterization (Photo courtesy of Longhorn Vaccines and Diagnostics).

Mouth Swab Molecular Test for Tuberculosis Validated

 Clinical investigators are testing an approach being developed to diagnose tuberculosis using mouth swabs, which could become an alternate approach to sample collection methods currently used to do tuberculosis (TB) testing. More...
22 Jan 2020
Image: The Oncotype DX specimen and collection kit for the Breast Cancer Recurrence Score Assay (Photo courtesy of Genomic Health).

21-Gene Recurrence Score Helps Radiation Decision-Making

 A new study shows that a test that physicians commonly used to guide chemotherapy treatment for post-breast cancer surgery patients may also help them decide whether radiation therapy may be of benefit. More...
21 Jan 2020
Image: Abnormal accumulation of tau protein in neuronal cell bodies (arrow) and neuronal extensions (arrowhead) in the neocortex of a patient who had died with Alzheimer's disease (Photo courtesy of Wikimedia Commons)

Acute Sleep Loss Triggers Increase in Plasma Levels of Tau Protein in Young Adults

 A team of Swedish researchers has found that acute sleep loss results in increased blood levels of t-tau protein, a key biomarker for nervous system disorders such as Alzheimer’s disease. More...
20 Jan 2020
Image: This micrograph depicts an atypical, enlarged lymphocyte found in the blood smear from a hantavirus pulmonary syndrome (HPS) patient. This large atypical lymphocyte is an example of one of the laboratory findings, which when combined with a bandemia, i.e., immature white blood cells, and dropping platelet count, is characteristic of HPS (Photo courtesy of Centers for Disease Control and Prevention)

Molecular Assays Developed for Hantavirus Pulmonary Syndrome

 Hantavirus Pulmonary Syndrome (HPS) is a serious and often fatal disease caused by viruses known as hantaviruses. These anthropozoonotic diseases comprising of two clinical entities: Hemorrhagic Fever with Renal Syndrome (HFRS), which occurs in the Old World, and Hantavirus Pulmonary Syndrome (HPS) in the New World. More...
16 Jan 2020
Image: Single nucleotide polymorphism: The upper DNA molecule differs from the lower DNA molecule at a single base-pair location (Photo courtesy of Marshall University).

Dual Nucleic Acid Template Assay Developed for Cancer

 Massive parallel sequencing or massively parallel sequencing is any of several high-throughput approaches to DNA sequencing using the concept of massively parallel processing; it is also called next-generation sequencing or second-generation sequencing. More...
16 Jan 2020
Image: Nextera XT DNA Library Preparation Kit (Photo courtesy of Illumina).

Extrachromosomal Circular DNA Identified in Maternal Plasma

 Circular cell-free DNA of both maternal and fetal origin can be identified in the plasma of pregnant women, pointing to a possible new type of biomarker for noninvasive prenatal testing (NIPT). More...
16 Jan 2020
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