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BioResearch

Image: T-cells (red) attacking melanoma cells (green). The neo-antigen-specific T- cells in this image are especially effective at killing cancer cells (Photo courtesy of the Weizmann Institute of Science).

Novel Approach Brings Personalized Melanoma Treatment Closer to Reality

A team of melanoma researchers used a novel "HLA peptidomics" method to identify and isolate cancer-specific neo-antigens, which could be used to train immune system cells for targeting and destruction of the tumor. More...
27 Sep 2018
Image: An argonaute protein from Pyrococcus furiosus; these proteins are the catalytic endonucleases in the RNA-induced silencing complex, the protein complex that mediates the RNA interference phenomenon (Photo courtesy of Wikimedia Commons).

Deleting Liver Protein Improves Glucose Metabolism

Researchers working with a mouse model have determined that the Argonaute 2 (Ago2) protein mediates RNA silencing, which regulates both intrinsic energy production and consumption and disturbs energy metabolism in the development of obesity. More...
26 Sep 2018
Image: A photomicrograph of a fibrotic liver section revealed by staining of collagen accumulation in a mouse with human-like NASH (Photo courtesy of the University of California, San Diego).

Caspase-2 Drives Progression of Fatty Liver Disease

The enzyme caspase-2 has been shown to be critically linked to the progression of nonalcoholic fatty liver disease (NAFLD) to the more serious and aggressive nonalcoholic steatohepatitis (NASH) form of the syndrome. More...
25 Sep 2018
Image: N. fowleri growth is inhibited with a combination treatment of breast cancer drug tamoxifen and epiminolanosterol (left) as compared to the untreated amoebae (right) (Photo courtesy of the University of California San Diego).

Approved Drugs Effectively Suppress Growth of Lethal Pathogen

Some currently approved drugs were found to suppress the growth of the amoeba Naegleria fowleri by inhibiting enzymes in the organism's sterol biosynthesis pathway. More...
24 Sep 2018
Image: Compared to a control (left), a soluble version of TLR5 (right) reduced the formation of amyloid plaques (brown) in the brains of mice that produced large amounts of human beta-amyloid (Photo courtesy of Chakrabarty et al., 2018).

Vaccination with Receptor Protein Protects Mice against AD

A soluble version of a protein involved in the formation of toxic amyloid plaques was shown to prevent aggregation of amyloid beta (Abeta) and slow development of Alzheimer's disease (AD) in a mouse model. More...
12 Sep 2018
Image: A photomicrograph of the Gram-positive bacterium, Propionibacterium acnes growing in thioglycollate medium. P. acnes bacteria, which normally reside in the sebaceous glands of the skin, are responsible for acne vulgaris, or pimples (Photo courtesy of the [U.S.] Centers for Disease Control and Prevention).

Early Stages Proceed in Development of Acne Vaccine

A potential vaccine to protect against development of acne is based on a virulence factor isolated from the bacteria that causes the severe skin inflammation. More...
11 Sep 2018
Image: In a recent study, CRISPR gene editing was shown to halt the progression of Duchenne muscular dystrophy (DMD) in dogs. The photomicrographs show dystrophin (in green) in a healthy diaphragm muscle (left), absence of dystrophin in a dog with DMD (center), and restoration of dystrophin in dogs treated with CRISPR (right) (Photo courtesy of the University of Texas Southwestern Medical Center).

Gene Editing Reverses DMD Muscle Damage in Model

The CRISPR/Cas9 genome-editing tool was used in a proof-of-concept study conducted in dogs suggested that the technique could be clinically useful for the treatment of Duchenne muscular dystrophy. More...
10 Sep 2018
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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