BioResearch
PB Transposon Mutagenesis Identifies Malaria Genes and Drug Targets
A team of genome researchers took advantage of the unusual nucleotide composition of Plasmodium falciparum DNA to create mutant strains of the malaria parasite in order to identify essential genes and potential drug targets. More...15 May 2018
Novel Biopsy Enabled by Focused Ultrasound and Microbubbles
A recent paper discussed the feasibility of using focused ultrasound in combination with microbubbles to generate the local release of mRNA from a glioblastoma tumor into the bloodstream for diagnosis of brain cancer by non-invasive liquid biopsy analysis. More...14 May 2018
Minor Blood Group Antigens Deleted by Gene Editing
The CRISPR/Cas9 gene-editing tool was used to create a line of red blood cells for transfusion that was completely deficient in blood groups encoded by five different genes that generate antigens responsible for the most common transfusion incompatibilities. More...12 May 2018
Model Demonstrates Potential for Long-Term Gene Silencing
An adeno-associated viral (AAV) vector was used to deliver a modified version of the CRISPR/Cas9 gene-editing tool to liver cells in a mouse model, which resulted in suppression of the serum enzyme Pcsk9 and reduction of cholesterol levels. More...08 May 2018
Protein Droplets Stimulate Neurodegenerative Fibril Clumping
A team of neurodegenerative disease researchers has identified a molecular mechanism that prevents or reverses the formation of insoluble protein aggregates that characterize several brain disorders, including frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). More...03 May 2018
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In Other News
Cardiomyocyte Extracellular Vesicles Repair Heart Damage in Model
Protein Supports Optimal Vascular System Performance
HTS Method Based on 3D Tumor Organoid Cultures
Ultrasensitive Imaging Enables Characterization of Individual Nanoparticles
Vaccine Induces Protective Immune Response in Mouse Model
Artificial RNAs Increase Precision of Gene-Editing System
Inhibiting Fibronectin Polymerization Reduces Injury to Cardiac Muscle
Bladder Cancer Organoids May Lead to Treatment Breakthrough
Vaccine Cures and Protects against West Nile Virus
Finnish Study Describes Activators of SIRT6 Gene
Nano-Imaging Reveals Links to Regulation of Bone Mineralization
Compound Demonstrates Potential as Broad-Spectrum Antiviral Drug
Stroke Genetics Study Triples Number of Known Risk Loci
Critical Brain Cell Repair Gene Identified in Study
Antibody Clears Amyloid Plaques in Mouse Model
Role of RNA Methylation Defined in Drug Resistance by Leukemia Cells
Less Toxic Drugs May Replace Current Chemotherapeutic Agents
Pecan-Enriched Diet Protects against CV Disease and Diabetes
Review Article Summarizes Progress Towards Drug Development
Nanospear Technology Developed for Directed Gene Therapy
Innovations Increase Sensitivity of CTC Detection
Novel Gene-Editing Tool Specifically Modifies RNA
Virtual Model Set to Boost Drug Development Efforts
BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
