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BioResearch

Image: A micrograph of a urine cytology specimen showing a polyomavirus infected cell (Photo courtesy of Wikimedia Commons).

New Liquid Biopsy Assay Reveals Host-Pathogen Interactions

A sensitive new assay employs high-throughput DNA sequencing to identify a large range of viral and bacterial pathogens in clinical samples, distinguish them from host DNA, and determine the degree of host tissue injury due to interaction with the pathogens. More...
09 Sep 2019
Image: The transverse section of a chorionic villus (Photo courtesy of Wikimedia Commons).

Method Developed for Enriching Trophoblast Population in Samples

A recent paper described a technique to increase the proportion of placental trophoblast cells in cervical samples by 700%, which enables individual trophoblasts to be picked out for genetic testing. More...
02 Sep 2019
Image: A scanning electron microscope (SEM) photograph of Papillomavirus particles (Photo courtesy of the Institut Pasteur/Odile Croissant).

RNA-Based Test Developed for HPV Detection and Cancer Diagnosis

An RNA-based diagnostic test was developed that can detect human papillomaviruses (HPVs) with performances comparable to or better than an HPV DNA-based reference diagnostic kit. More...
19 Aug 2019
Image: Circulating tumor DNA (ctDNA) is found in serum and plasma fractions from blood. The mechanism of ctDNA release is unknown, though apoptosis, necrosis, and active secretion from tumor cells have been hypothesized (Photo courtesy of Wikimedia Commons).

Ultrasensitive Biopsy Technique Monitors Risk of Cancer Recurrence

An ultrasensitive liquid biopsy technique, which may be personalized for each breast cancer patient, can be used to monitor the patient over time and allow early detection of tumor recurrence. More...
19 Aug 2019
Image: The presence of lymphocytes within the tubular epithelium, attesting to acute cellular rejection of a renal graft (Photo courtesy of Wikimedia Commons).

Gene Panel Detects Early Signs of Kidney Transplant Rejection

A team of European kidney transplantation researchers has developed and validated an mRNA-based gene set found in peripheral blood that can identify patients with symptoms of antibody-based kidney transplant rejection. More...
12 Aug 2019
Image: A micrograph of non-alcoholic fatty liver disease (NAFLD). The liver has a prominent (centrilobular) macrovesicular steatosis (white/clear round/oval spaces) and mild fibrosis (green). The hepatocytes stain red. Macrovesicular steatosis is lipid accumulation that is so large it distorts the cell\'s nucleus (Photo courtesy of Wikimedia Commons).

Single Mutation Linked to Fatty Disorders of Liver and Skin

The common liver disorder non-alcoholic fatty liver disease (NAFLD) has been found to share a genetic linkage with Chanarin-Dorfman syndrome, a rare skin condition. More...
05 Aug 2019
Image: In brains affected by Alzheimer’s disease, abnormal levels of the beta-amyloid protein clump together to form plaques (seen in brown) that collect between neurons and disrupt cell function. Abnormal collections of the tau protein accumulate and form tangles (seen in blue) within neurons, harming synaptic communication between nerve cells (Photo courtesy of the [U.S.] National Institute on Aging).

Using Transcriptome Analysis to Detect Asymptomatic Alzheimer’s Disease

Transcriptome analysis was used as a method for detecting individuals with Alzheimer’s disease (AD) who were not yet displaying symptoms of the disorder. More...
29 Jul 2019
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.