BioResearch
Suppression of a Specific Kinase Blocks Growth of Dependent Tumors
A recent paper revealed that the enzyme glycogen synthase kinase 3 (GSK3) was required for the in vitro and in vivo growth and survival of human mutant KRas-dependent tumors but was dispensable for mutant KRas-independent tumors. More...20 Dec 2018
Gene Therapy Treatment Uses Microparticles to Deliver DNA or RNA
A novel gene therapy approach for correcting hereditary blood disorders is based on the use of megakaryocytic microparticles (MkMPs) to deliver plasmid DNAs and small RNAs to hematopoietic stem and progenitor cells (HSPCs). More...18 Dec 2018
DNA Methylation Pattern May Be Biomarker for Cancer Detection
A team of Australian researchers has determined that a characteristic pattern of methylated DNA allows for easy detection of the genomes of cancerous cells and may serve as a universal biomarker for rapid diagnosis of many types of cancer. More...17 Dec 2018
Nanoparticle Assay Detects Respiratory Bacteria in Pneumonia Model
Researchers used a mouse pneumonia model to demonstrate how a nanoparticle-based technique could be used to detect Pseudomonas aeruginosa bacteria in infected animals and monitor bacterial clearance from their lungs during the course of antibiotic treatment. More...13 Dec 2018
Deeply Penetrating Nanoparticles Designed to Treat Osteoarthritis
A novel nanoparticle-based drug transport system designed to treat osteoarthritis delivers the anabolic growth factor IGF-1 (insulin-like growth factor 1) directly to injured chondrocytes, which are located deep within a dense layer of cartilage tissue. More...12 Dec 2018
Diabetes Researchers Convert Stem Cells into Insulin-Producing Cells
A team of stem cell biologists working on the problem of pancreas replacement in patients with type I diabetes identified the extrinsic and intrinsic signaling mechanisms that coordinate the fate-determining transcriptional events underlying the maturation of bipotent pancreatic progenitors and used this information to convert these pancreatic progenitors - derived from human embryonic stem cells - to insulin-producing islet cells. More...11 Dec 2018
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In Other News
Analytical Tools Reveal Molecular Mechanism of Gene-Editing Tool
Hormone Treatment Linked to Development of Aggressive Cancer
Mannose Treatment Enhances Chemotherapy and Slows Growth of Cancers
Novel DNA Vaccine Prevents AD in Mouse Model
Subpopulation of Fibroblasts Drives Breast Tumor Development
African Folk Drug Modulates Critical Potassium Channel Protein
Protein Crystals Used to Prepare Cellular Drug Delivery Nanotubes
Modified Nanoparticle Drug Carriers Target Solid Tumors in Model
New Method Eliminates Unwanted Neurons from Cultures of Kidney Organoids
Linked Antibodies Provide Universal Protection from Influenza Infection
Technology Evaluated for T-cell Receptor Identification and Cloning
Nanoneedle Bio-patch Provides Minimally Invasive Drug Delivery
Mutation in p53 Suppressor Gene Drives Tumor Development
Biodegradable Nanoscaffolds Improve Chances for Stem Cell Therapies
In vivo CRISPR/Cas9 Therapy Prevents Arrhythmias in Model
Mechanism Explains Why Damaged DNA Accumulates in ALS Neurons
Immune Sensitivity Hampers Clinical Applications of CRISPR/Cas9
Proposed Treatment Aims to Re-Sensitize Cancer Cells
Tumor-Secreted Ligands Induce Fibroblast Behavior
Novel CDK9 Inhibitor Prevents Cancer Growth
Dysregulation of Retinoic Acid Signaling in Stem Cells Spurs Tumor Growth
Functional 3D Neural Network Models Generated from Stem Cells
Antisense DNA Drug Cures Prostate Cancer in Model
BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
