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Immunology

Image: Innate immune cells: heterozygous mutations of the RIPK1 caspase-8 cleavage site cause the autoinflammatory disease CRIA syndrome (Photo courtesy of Walter and Eliza Hall Institute)

New Human Autoinflammatory Disease Identified

 Autoinflammatory diseases are caused by abnormal activation of the innate immune system, leading to recurrent episodes of fever and inflammation that can damage vital organs. More...
24 Dec 2019
Image: The BD FACSAria III fluorescent activated cell sorter used to enumerate circulating progenitor cells (Photo courtesy of Becton, Dickinson and Company.

Circulating Progenitor Cell Traffic Reflects Blood Vessel Repair

 Identifying patients with otherwise stable coronary artery disease (CAD) who are high-risk and would benefit from more intense or invasive interventions is currently a major theme in cardiology studies. More...
18 Dec 2019
Image: Histological slide of the human herpes virus-6 showing infected cells, with inclusion bodies in both the nucleus and the cytoplasm. A new method has been developed to separate between two different types of a common herpes virus, and HHV-6 has been linked to multiple sclerosis (Photo courtesy of National Cancer Institute)

Multiple Sclerosis Linked to Variant of Common Herpes Virus

 Multiple sclerosis, MS, is an autoimmune disease that affects the central nervous system. The cause of the disease is unclear, but one plausible explanation is a virus deceives the immune system to attack the body's own tissue. More...
12 Dec 2019
Image: The ARCHITECT Anti-HCV assay is a fully automated high throughput chemiluminescent microparticle immunoassay (CMIA) for the detection of antibodies to structural and nonstructural proteins of the hepatitis C virus (HCV) (Photo courtesy of Abbot Diagnostics)

Diagnosis and Monitoring of Patients with Hepatitis C Virus

 The global prevalence of people with hepatitis C virus (HCV) antibodies (anti-HCV-positive) is estimated to be 115 million, and 80 million of them have an active infection (anti-HCV-positive and HCV-RNA-positive). More...
11 Dec 2019
Image: HbA1c Advanced Clinical Chemistry Diabetes Assay: to diagnose maturity-onset diabetes of the young (MODY), screening for at least three autoantibodies and HbA1c testing should takes place in all youth at the time of diabetes diagnosis (Photo courtesy of Beckman Coulter)

Three Factors Distinguish MODY, a Rare Diabetes, in Youth

 Identifying maturity-onset diabetes of the young (MODY) in pediatric populations close to diabetes diagnosis is difficult. Misdiagnosis and unnecessary insulin treatment are common. MODY is a monogenic, dominantly inherited form of diabetes that typically arises in adolescence or young adulthood, and accounts for 1%-4% of cases of pediatric diabetes. More...
10 Dec 2019
Image: Blood test for Zika MAC-ELISA: Zika Virus IgM Persists 25 Months After Symptom Onset (Photo courtesy of Darren Ellis)

Zika Virus IgM Persists 25 Months After Symptom Onset

 Zika virus disease is caused by a virus transmitted primarily by Aedes mosquitoes, which bite during the day. Symptoms are generally mild and include fever, rash, conjunctivitis, muscle and joint pain, malaise or headache. Symptoms typically last for 2–7 days. More...
05 Dec 2019
Image: Colonies of Burkholderia pseudomallei on Ashdown`s agar after four days` incubation (Photo courtesy of Gavin Koh)

Plasma Cytokine Responses Characterized in Melioidosis

 Melioidosis, an infectious disease caused by the environmental saprophyte Burkholderia pseudomallei, is endemic across many areas of Southeast Asia, South Asia, Northern Australia and America. B. pseudomallei is a facultative intracellular bacterium, a characteristic that contributes to its pathogenesis and persistence in the host and that may modulate the cytokine response to infection. More...
04 Dec 2019
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.