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Molecular Diagnostics

Image: The QX200 Droplet Digital PCR System provides absolute quantification of target DNA or RNA molecules (Photo courtesy of Bio-Rad Laboratories).

HPV DNA Test Monitors Remission in Oral Cancer

A blood-based method has been developed to test patients with human papillomavirus-associated oral cancers for signs of remission or recurrence. This approach would potentially allow doctors to more accurately and more easily identify which patients are free from cancer after radiation treatment, and which might be poised to recur. More...
06 Nov 2018
Image: Researchers have developed the first diagnostic platform that can simultaneously screen for all known human pathogenic bacteria, as well as markers for virulence and antibiotic resistance (Photo courtesy of Columbia University).

Ultrasensitive Screening Platform Detects Pathogenic Bacteria

A diagnostic platform has been developed that significantly increases the sensitivity of high-throughput sequencing for detection and characterization of bacteria, virulence determinants, and antimicrobial resistance (AMR) genes. More...
05 Nov 2018
Image: The HiSeq 2500 System is a powerful high-throughput sequencing system (Photo courtesy of Illumina).

Functional Genomic Landscape of AML Analyzed

Acute myeloid leukemia is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells. More...
01 Nov 2018
Image: A blood smear from a 68-year-old woman with a 13-year history of polycythemia vera and there are three red blood cell precursors present and slight to moderate anisopoikilocytosis (Photo courtesy of The Armed Forces Institute of Pathology).

Myeloproliferative Neoplasms Fall into Genetic Subgroups

Myeloproliferative neoplasms are a group of chronic blood cancers associated with a risk of bleeding and blood clots, but they can also progress to more advanced disease, including leukemia. More...
31 Oct 2018
Image: Deeplex-MycTB deep sequencing test analyses a wide panel of target genes in the bacteria and can identify resistance to over a dozen antibiotics simultaneously (Photo courtesy of Genoscreen).

Multidrug-Resistant TB Outbreak Undetected by Standard Tests

Rapid diagnosis of Mycobacterium tuberculosis resistant to anti-tuberculosis drugs is essential to prevent further acquisition of drug resistance, high morbidity and mortality, and unabated transmission of resistant strains. More...
31 Oct 2018
Image: The Dade Behring BN100 nephelometer (Photo courtesy of Siemens Healthineers).

Chronic Inflammation Linked to Risk for Alzheimer's Disease

While it has been widely shown that possessing the apolipoprotein E4 (ApoE4) gene is the major genetic risk factor of Alzheimer's disease (AD), not all ApoE4 carriers develop AD. It is likely that a complex interaction of genetic vulnerabilities with environmental risk factors lead to AD and identifying such factors could be beneficial for the prevention of AD. More...
30 Oct 2018
Image: A photomicrograph from a prostate biopsy of prostatic adenocarcinoma, conventional (acinar) type, the most common form of prostate cancer (Photo courtesy of Nephron).

Fatal Prostate Cancer Differentiated from Manageable Cancer

Human prostate cancers display numerous DNA methylation changes compared to normal tissue samples. However, definitive identification of features related to the cells’ malignant status has been compromised by the predominance of cells with luminal features in prostate cancers. More...
29 Oct 2018
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.