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Molecular Diagnostics

Image: A photomicrograph showing tumor-infiltrating lymphocytes in a case of colorectal cancer with evidence of high microsatellite instability (MSI-H) on immunostaining (Photo courtesy of Nephron).

Biomarker Predicts Appropriate Immunotherapy for Cancer Patients

Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA mismatch repair activity. MSI is detected in about 15% of all colorectal cancers; 3% are of these are associated with Lynch syndrome. MSI is a biomarker for response to immune checkpoint inhibitors (ICPIs). More...
14 May 2019
Image: A photomicrograph of human papilloma virus associated oropharyngeal cancer. The tissue has been stained to show the presence of the virus by in situ hybridization (Photo courtesy of Jennifer L. Hunt, MD).

Oral HPV-DNA Persists after Oropharyngeal Cancer Treatment

Head and neck cancers affect some 53,000 people in the USA each year, according to the National Cancer Institute, and human papilloma virus (HPV) has been implicated in many of those cases. The diagnosis of cancer can be confirmed by tissue biopsy. More...
14 May 2019
Image: The SureSelect XT combines sequencing library preparation and gDNA preparative reagents with the SureSelect target enrichment system (Photo courtesy of Agilent Technologies).

Liquid Biopsy Utility Reinforced in Early Cancer Trials Results

Next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) supports blood-based genomic profiling but is not yet routinely implemented in the setting of a clinical phase I trials. More...
09 May 2019
Image: The NovaSeq 6000 system offers high-throughput sequencing across a broad range of applications (Photo courtesy of Illumina).

Machine-Learning System Used to Diagnose Genetic Diseases

By informing timely targeted treatments, rapid whole-genome sequencing can improve the outcomes of seriously ill children with genetic diseases, particularly infants in neonatal and pediatric intensive care units (ICUs). More...
07 May 2019
Image: The QuickGene-610L nucleic acid isolation system (Photo courtesy of Autogen).

New Genetic Test Detects Mutations in High-Risk Groups

A new low-cost genetic test has been developed that accurately identified more than 200 known disease-causing gene variations in two high-risk populations, the Old Order Amish and Old Order Mennonites of Lancaster County, Pennsylvania. More...
07 May 2019
Image: The MinION is the only portable real-time device for DNA and RNA sequencing (Photo courtesy of Oxford Nanopore).

Sequencing Shows Promise for Diagnosing Prosthetic Joint Infections

A method is being developed for diagnosing infections associated with prosthetic joint implants that promises to provide results in a matter of hours as opposed to a week or more. More...
07 May 2019
Image: Neurofilaments (red) in cultured rat brain cells (Photo courtesy of Wikimedia Commons).

Neurofilament Light Considered as NIV Biomarker for Alzheimer's Disease

Results presented in a recently published paper suggested that plasma neurofilament light protein may serve as a noninvasive biomarker to monitor neurodegeneration in Alzheimer disease (AD). More...
06 May 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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