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Molecular Diagnostics

Image: Identifying a metastatic colorectal cancer patient’s Consensus Molecular Subtype (CMS) could help oncologists determine the most effective course of treatment (Photo courtesy of University of Southern California).

Identifying Colorectal Cancer Subtypes Improves Treatment Decisions

Colorectal cancer is the second leading cause of cancer death in the USA, and is expected to cause about 51,000 deaths in 2019, but until now, it was unclear which drugs were most effective for which patients. More...
25 Jun 2019
Image: A colorized electron micrograph showing malaria parasite (right, blue) attaching to a human red blood cell. The inset shows a detail of the attachment point at higher magnification (Photo courtesy of [U.S.]NIAID via Wikimedia Commons).

Blood Drop Assay Designed for Monitoring Antimalarial Drug Resistance

A new method for analyzing DNA directly in a drop of blood was designed for monitoring development of resistance to antimalarial drugs. More...
24 Jun 2019
Protocol summary of Vibrio cholerae DNA harvest from specimens preserved on filter paper cards (Photo courtesy of Wellcome Trust Sanger Institute).

Cholera Diagnosed from Dried Spotted Filter Paper

 Cholera outbreaks can rapidly induce high death tolls by overwhelming the capacity of health facilities, especially in remote areas or areas of civil unrest. Global estimates for cholera annually approximate four million cases worldwide with 95,000 deaths. More...
20 Jun 2019
A histopathology of pancreatic ductal adenocarcinoma, a gland-forming cancer. In this example, the adenocarcinoma has wrapped around a nerve (center of the image) (Photo courtesy of JHM).

Novel Methylated DNA Markers Assay Detects Cancer

 An estimated 56,770 people will be diagnosed with pancreatic cancer in the U.S. in 2019, and more than 45,750 will die from the disease. Pancreatic cancer is the third leading cause of cancer-related deaths in the U.S. and is expected to become the second leading cause by 2020. More...
20 Jun 2019
Representative histologic features of the small intestine. In the normal duodenal biopsy (A), the villi are elongated and the crypts relatively short. This is in contrast to the small intestinal tissue affected by celiac disease (B), which demonstrates marked villus blunting and crypt hyperplasia. (Photo courtesy of Tracy R. Ediger MD, and Ivor D. Hill, MD ChB).

Biomarker Found for Celiac Patients on Gluten-Free Diet

 Celiac disease is a complex condition, routinely treated by means of a strict gluten-free diet (GFD). One of the diagnostic challenges of this disease is that patients need to be consuming gluten so that a correct diagnosis by means of endoscopy can be made. More...
19 Jun 2019
A new study validated the use of tumor markers to select chemotherapy drugs for patients with metastatic pancreatic cancer (Photo courtesy of SPL).

Study Results Validate Use of Tumor Markers to Treat Metastatic Cancer

 Promising results obtained in a recently conducted pilot study demonstrated the feasibility of using molecular tumor markers as the basis for selecting the chemotherapeutic agents to use in patients with metastatic pancreatic cancer. More...
17 Jun 2019
In this photomicrograph, the brown areas were stained for a biomarker in tissue from a patient who developed pancreatic cancer from a cyst (Photo courtesy of Dr. Koushik Das, Washington University).

Immunodiagnostic Test Predicts Progression of Pancreatic Cyst to Cancer

 By using an immunodiagnostic test to detect the Das-1 antibody biomarker in fluid from pancreatic cysts, researchers were able to identify those cysts that were likely to become cancerous with 95% accuracy. More...
17 Jun 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.