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Molecular Diagnostics

Image: Solution structure of IL-18 (interleukin 18) protein (Photo courtesy of Wikimedia Commons)

Protein Panel Predicts Risk for Development of Cerebral Small Vessel Disease

 A network of six inflammatory biomarkers centered on interleukin-18 (IL-18) is able to predict risk for development of cerebral small vessel disease (CSVD), a brain disease currently diagnosed by MRI (magnetic resonance imaging) scan. More...
17 Feb 2020
Image: Histopathology of early gastric cancer, an intramucosal adenocarcinoma. A blood test used in a targeted methylation (TM) sequencing assay may help detect hard-to-detect gastrointestinal cancers in asymptomatic individuals (Photo courtesy of Andrey Bychkov, MD, PhD).

Blood Test Lead to Earlier Detection of Gastrointestinal Cancers

 Gastrointestinal cancer refers to malignant conditions of the gastrointestinal tract (GI tract) and accessory organs of digestion, including the esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum and anus. More...
13 Feb 2020
Image: The FUJI DRI-CHEM IMMUNO AG1 analyzer (Photo courtesy of FUJI FILM).

Rapid Antigenic Diagnostic Test Validated for Ebola Virus Disease

 Hemorrhagic fever outbreaks are difficult to diagnose and control in part because of a lack of low-cost and easily accessible diagnostic structures in countries where etiologic agents are present. Initial clinical symptoms are common and shared with other endemic diseases such as malaria or typhoid fever. More...
13 Feb 2020
Image: Structure of the lipocalin 2 (LCN2) protein (Photo courtesy of Wikimedia Commons)

Lipocalin 2 Identified as Biomarker for Differential Diagnosis of Vascular Dementia

 Results obtained by a study conducted by several European research institutes suggest that lipocalin 2 is a promising biomarker for the differential diagnosis of vascular dementia. More...
12 Feb 2020
Image: Illustration of a 2019- novel coronavirus (nCoV) virion (Photo courtesy of Alissa Eckert, MS/CDC).

CDC Provides Test Protocol for Novel Coronavirus

 The US Centers for Disease Control and Prevention (Atlanta GA, USA) has publicly posted its assay for novel coronavirus 2019-nCoV and is now developing the test into kits. The CDC diagnostic test is a reverse transcriptase real-time PCR (rRT-PCR) assay developed for respiratory and blood serum samples. The protocol to make the assay has been made publicly available. More...
11 Feb 2020
Image: Workflow of cancer personalized profiling by deep sequencing (CAPP-Seq) circulating tumor-DNA analysis (ctDNA) (Photo courtesy of Rashedul Islam Rony, PhD).

Lung Cancer Liquid Biopsy Guides MRD-Directed Adjuvant Therapy

 Minimal residual disease (MRD) is the name given to small numbers of leukemic cells (cancer cells from the bone marrow) that remain in the person during treatment or after treatment when the patient is in remission or have no symptoms or signs of disease. More...
11 Feb 2020
Image:  Human sperm stained for semen quality testing in the clinical laboratory (Photo courtesy of Wikimedia Commons)

Detection of Pathogenic Microorganisms in Semen by Sequencing Sperm RNA

 Advanced sequencing of sperm RNA was used to detect genetic material from microorganisms that were present as contaminants in the associated semen. More...
11 Feb 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.