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Molecular Diagnostics

Image: A scanning electron micrograph (SEM) of lung cancer cells (Photo courtesy of Cancer Research UK).

Immune Relationship to Lung Tumor Evolution Characterized

Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). NSCLC accounts for about 85% of all lung cancers. As a class, NSCLCs are relatively insensitive to chemotherapy, compared to small cell carcinoma. More...
04 Apr 2019
Image: A diagram of evolutionary trajectories of IDH-WT glioblastomas revealing a common path of early tumorigenesis instigated years ahead of initial diagnosis (Photo courtesy of German Cancer Research Center).

Glioblastoma Driver Mutations Appear Long Before Diagnosis

Glioblastomas are the most common high-grade (cancerous) primary brain tumor in adults. They can also occur, rarely, in children. Glioblastomas belong to a group of brain tumors known as gliomas, as they grow from a type of brain cell called a glial cell. More...
03 Apr 2019
Image: The HiSeq 2500 System is a powerful high-throughput sequencing system (Photo courtesy of Illumina).

Preterm Birth Clues Identified in Cervicovaginal Microbiome

Failure to predict and understand the causes of preterm birth, the leading cause of neonatal morbidity and mortality, have limited effective interventions and therapeutics. Preterm birth (PTB) is defined as birth before 37 completed weeks of gestation and is the leading cause of death in neonates and children under the age of 5. More...
03 Apr 2019
Image: A close-up of the CRISPR-Chip device (Photo courtesy of Keck Graduate Institute).

Biosensor Device Uses CRISPR-Cas9 to Detect Target DNA Sequence

A team of biomedical engineers has developed and tested a graphene-based biosensor device that uses CRISPR/Cas9 technology to enable the digital detection of a target DNA sequence within intact genomic material. More...
01 Apr 2019
Image: Infinium arrays: microarrays are the ideal platform for assessing known markers in the human genome (Photo courtesy of Illumina).

Adverse Drug Response Risk Gene Identified for IBD

Investigators have uncovered genetic variants in a gene called Nudix hydrolase 15 (NUDT15) that seem to coincide with treatment-related complications in individuals of European ancestry with inflammatory bowel disease (IBD). More...
28 Mar 2019
Image: A histopathology of hepatocellular carcinoma: a mononuclear inflammatory cell infiltrate extends from portal areas and disrupts the limiting plate of hepatocytes which are undergoing apoptosis, the so-called interface hepatitis of chronic active hepatitis. In this case, the hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (HBcAb) were positive (Photo courtesy of University of Utah Medical School).

Virus-Associated Liver Cancer Detected by Blood Tests

Viral infection with either hepatitis C virus (HCV) or Hepatitis B virus (HBV) is the chief cause of liver cancer in the world today, accounting for 80% of hepatocellular carcinoma (HCC). The viruses cause HCC because massive inflammation, fibrosis and eventual cirrhosis occurs within the liver. More...
27 Mar 2019
Image: Low levels of amyloid-beta and tau proteins in the vitreous humor were indicative of potential Alzheimer\'s disease risk (Photo courtesy of Wikimedia Commons).

AD Biomarkers in Ocular Fluid Indicate Dementia Risk

Measuring levels of amyloid-beta and tau proteins in the eye's vitreous humor has been suggested as means to detect dementia at an early stage in individuals at risk for Alzheimer's disease (AD). More...
25 Mar 2019
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