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Molecular Diagnostics

Padlock Probe Assay Detects and Subtypes Seasonal Influenza

Influenza remains a constant threat worldwide, and it is estimated that it affects 5% to 15% of the global population each season, with an associated three to five million severe cases and up to 500,000 deaths. More...
24 Jan 2019
Image: The Affymetrix Genechip 3000 microarray scanner and autoloader fluidics station 450 (Photo courtesy of New-life Scientific).

Molecular Prognostic Biomarker Found for CNS Lymphoma

Primary central nervous system lymphoma (PCNSL), a rare subgroup of diffuse large B-cell lymphoma (DLBCL) arising in the central nervous system (CNS), is an aggressive malignant variant of nodal non-Hodgkin lymphoma (NHL). PCNSLs account for 3% of all primary CNS tumors and 1% of NHLs in adults. More...
24 Jan 2019
Image: The CFX384 real-time PCR detection system (Photo courtesy of Bio-Rad Laboratories).

Gene-Based Risk Scores Predicts Alcoholic Cirrhosis

Alcoholic chronic liver disease, with a prevalence of around 12% in the European and North-American populations, is characterized by a broad spectrum of conditions ranging from simple steatosis to alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. More...
23 Jan 2019
Image: The RevertAid First Strand cDNA Synthesis Kit is a complete system for efficient synthesis of first strand cDNA from RNA templates (Photo courtesy of Thermo Fisher Scientific).

Prognostic Signature Described in HPV-Positive Cell Carcinomas

Human papilloma virus (HPV) is an etiological agent of oropharyngeal squamous cell carcinoma (OPSCC). Patients with HPV+ OPSCC have high long-term survival rates: however, current radiation protocols are aggressive and can result in life-long morbidities, including difficulty swallowing, chronic dry-mouth, and altered speech. More...
23 Jan 2019
Image: A sketch of µLAS chip with two independent channels actuated with the same pressure and voltage. Each channel contains a funnel region that functions to separate and concentrate DNA in line (Photo courtesy of University of Lausanne).

Genetic Methods Rapidly Diagnoses Huntington's Disease

People with Huntington's disease suffer from jerky body movements and decreasing mental abilities. The condition usually leads to death 15 to 20 years after diagnosis. The cause of the disease is a region in the Huntingtin gene (HTT) that is absent in healthy people. More...
23 Jan 2019
Image: The Synergy H1 multi-mode microplate reader (Photo courtesy of BioTek).

Urinary Detection Method Developed for Prostate Cancer

Prostate cancer (PCa) is one of the most common types of malignancy worldwide and is the second leading cause of cancer death among men. This cancer tends to be asymptomatic and slow growing, often with onset in young men, but usually not detected until the age of 40 to 50 years. More...
22 Jan 2019
Image: The APOL1 G1 and G2 risk alleles in 111 global reference populations (Photo courtesy of the Icahn School of Medicine).

Latinos and Hispanics Prone to Kidney Disease Gene Variant

Risk variants in the apolipoprotein A-I (APOL1) gene on chromosome 22, which were first discovered in African Americans, confer a substantially increased risk of kidney disease, early-onset hypertension, and cardiovascular disease, although disease risk is modified by other genetic factors and by environmental factors. More...
21 Jan 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.