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Molecular Diagnostics

Image: Immunohistochemistry image of invasive squamous cell carcinomas of tonsil tissue showing overexpression of p16, which is a very good surrogate marker for HPV infection (Photo courtesy of David C. Hoak, MD).

New Genetic Factors Linked to HPV-Related Cancers

A new, large-scale genetic study of head and neck cancers shows why some individuals infected with human papillomavirus (HPV) may go on to develop oropharyngeal cancer while others do not. More...
04 Nov 2016

Testing Method Clinically Ascertains Genetic Basis for Hypercholesterolemia

Next-generation sequencing technology is transforming our understanding of heterozygous familial hypercholesterolemia, including revision of prevalence estimates and attribution of polygenic effects. More...
03 Nov 2016
Image: Motor neurons of Drosophila showing that expression of variant p.Arg534Trp of the fly’s equivalent of human ATAD3A gene causes a decrease in the number of mitochondria (green). Top row, control; middle row, motor neurons with normal (wild type) fly’s equivalent of human ATAD3A gene; bottom row, motor neurons with variant R534W of the fly’s equivalent of human ATAD3A gene. VNC, ventral nerve cord; Neurons are labeled in blue and boutons, an area of synapsis with another neuron, in red (Photo courtesy of The American Journal of Human Genetics).

Gene Abnormality Found to Underlie Rare Neurological Disease

Researchers have discovered that malfunctioning variants of a gene encoding a mitochondrial protein results in a group of related neurological syndromes classified as conditions of unknown origin. The study sheds new light on causes of such diseases and opens a door for developing better diagnostic tools and treatments. More...
03 Nov 2016
Image: The Access Array microfluidic system generates next-generation sequencing (NGS) (Photo courtesy of Fluidigm).

Non-Invasive Assay Improves Surveillance of Solid-Organ Transplants

Patients who have received a solid organ transplant require lifelong immunosuppressive therapy. The threat of transplant rejection due to insufficient drug therapy must be balanced against increased risks of infections and cancer from excessive immunosuppression. More...
28 Oct 2016
Image: The Metafer Vslide scanning system connected to a Zeiss microscope (Photo courtesy of MetaSystems).

Low Cost Method Examines Single Leukemic Cells

Leukemia is a disease in which each cell can exhibit different genetic traits, and a cheap way has been developed to examine the individual cells and this breakthrough could transform leukemia treatment. More...
28 Oct 2016
Image: The LabTurbo 48 compact system can fully automate DNA/RNA extraction of up to 48 samples in 90 minutes (Photo courtesy of Taigen Bioscience).

Commercial Molecular Assay Validated for Dengue Virus Outbreak

Dengue virus (DENV) is a member of the viral genus Flavivirus (family Flaviviridae) that is transmitted by mosquitos, causing endemic and epidemic outbreaks in tropical and subtropical areas. More...
28 Oct 2016
Image: A histopathology of a moderately differentiated adenocarcinoma of colon showing a glandular configuration, but the glands are irregular and very crowded. Many of them have lumens containing bluish mucin (Photo courtesy of Raul Gonzalez MD).

Blood Test for Colorectal Cancer Recurrence Proves Highly Sensitive

When diagnosed early, before cancer has spread, the relative five-year survival rate for colorectal cancer (CRC) is 90%, but only approximately four out of 10 CRC cases are detected early. More...
27 Oct 2016
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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