Molecular Diagnostics
Fluorescent Markers May Aid Cancer Diagnostics by Tracking Metabolites
A novel class of fluorescent markers allows real‐time tracking of essential metabolites in live cells in culture and in vivo in order to trace the acquisition of metabolic profiles from human cancer cells of variable origin. More...15 Apr 2019
Nuclear Hormone Expression Predicts Cancer Aggressiveness
A large-scale retrospective analysis in patients revealed that expression of the nuclear hormone receptor "retinoic-acid-receptor-related orphan receptor gamma" (RORgamma) could predict pancreatic cancer aggressiveness, since it correlated positively with advanced disease and metastasis. More...15 Apr 2019
Fusion Genes Diagnosis Uses Targeted RNA Sequencing
Chromosomal rearrangements that juxtapose two different genes together can form a fusion gene. Fusion genes play a causal role in tumorigenesis, accounting for ~20% of human cancer morbidity. However, the prevalence of fusion genes varies widely across different cancers, and many fusion genes are specific to certain cancer sub-types. More...10 Apr 2019
Liquid Biopsy Potential Tested with ddPCR Technology
Droplet digital polymerase chain reaction (ddPCR) technology has been used to investigate the benefits of tracking drug-resistance mutations in the circulating DNA (ctDNA) of patients with hormone receptor-positive (HR+) metastatic breast cancer. More...10 Apr 2019
Genomic Analysis Used to Diagnose Neurodevelopmental and Congenital Anomalies
A recent paper described the use of genomic DNA methylation analysis to facilitate the molecular diagnosis of unresolved clinical cases of neurodevelopmental and congenital anomalies (ND/CAs) and highlighted the potential value of epigenomic testing in the routine clinical assessment of these disorders. More...08 Apr 2019
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In Other News
Genomic Alterations and Expression Profiles Diagnose AEL
Digital PCR Assay Diagnoses Paucibacillary Leprosy
Immune Relationship to Lung Tumor Evolution Characterized
Glioblastoma Driver Mutations Appear Long Before Diagnosis
Preterm Birth Clues Identified in Cervicovaginal Microbiome
Biosensor Device Uses CRISPR-Cas9 to Detect Target DNA Sequence
Adverse Drug Response Risk Gene Identified for IBD
Virus-Associated Liver Cancer Detected by Blood Tests
AD Biomarkers in Ocular Fluid Indicate Dementia Risk
Reaction to Vancomycin Linked to Immune System HLA Variant
Fast Diagnosis of Sporotrichosis Based on RT-PCR
Five-Gene Signature Predicts Survival from Renal Cell Carcinoma
EBUS More Reliable Than Histology for Cancer Diagnoses
Researchers Lay Groundwork for Graphene-based Diagnostic Devices
New Genetic Loci Link to Insufficient and Excessive Sleep Duration
Genetic Markers Predict Susceptibility of Pancreatic Tumors
Study Identifies Gene Variations for Mouth Ulcers
Rapid Molecular Test Detects Macrolide Resistance
Liquid Biopsy Proves Effective as Biopsy for NSCLC
Blood Test Predicts Kidney Transplant Rejection
Alzheimer's Disease Meta-Analysis Identifies New Risk Genes
Clinical ddPCR Diagnostic Test System Gets FDA Clearance
Circulating Plasma DNA Potentially Identifies Incipient Tumors
Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
