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Molecular Diagnostics

Image: Immunofluorescence image of microglial cells stained red with antibody. DNA shown in blue (Photo courtesy of Wikimedia Commons)

Non-coding Regions of the Genome in Microglia Linked to Alzheimer’s Disease Risk

 A recently published paper linked risk of developing Alzheimer’s disease (AD) to enhancers - non-coding DNA regions of the genome - that were present in microglia but not in other types of brain cells such as neurons or astrocytes. More...
28 Nov 2019
Image: Human sperm stained for semen quality testing in the clinical laboratory (Photo courtesy of Wikimedia Commons)

Epigenetic DNA Biomarkers Pinpoint Infertile Men and Predict Potential Success of Treatment

 A molecular analysis method was developed that identifies infertility in men through evaluation of genome wide alterations in sperm DNA methylation. More...
27 Nov 2019
Image: Small particle LDL has been associated with the progression of atherosclerosis and blockage the artery lumen, because it can carry cholesterol into smaller vessels. As atheroma enlarges, the arterial wall ruptures and releases blood clots that lead to narrowing of the artery (Photo courtesy of Wikimedia Commons)

LDL Subclasses Ratio Predicts Cardiovascular Disease Risk More Accurately than LDL-cholesterol Alone

 Measurement of low-density lipoprotein (LDL) cholesterol may a less effective way to predict risk of cardiovascular disease than is the further analysis of the relative proportions of LDL subclasses. More...
27 Nov 2019
Image: Photograph of an iris melanoma (Photo courtesy of Wikimedia Commons)

MicroRNA Panel Distinguishes Benign Moles from Melanoma in the Eye

 A blood test based on a panel of six microRNAs (miRNAs) is able to distinguish non-cancerous nevi from malignant melanoma in the eye. More...
27 Nov 2019
Image: Growth characteristics of rough and smooth phenotypes of Mycobacterium abscessus on 7H11 agar cultured at 37 °C: representative single rough (left) and smooth (right) colonies (Photo courtesy of Hannover Medical School)

Mycobacterium Infection Found in Gastric Patients’ Stomachs

 Development of gastric diseases such as gastritis, peptic ulcer and gastric cancer is often associated with several biotic and abiotic factors. Helicobacter pylori infection is such a well-known biotic factor. However, not all H. pylori-infected individuals develop gastric diseases and not all individuals with gastric diseases are infected with H. pylori. More...
26 Nov 2019
Image: Novel, high-accuracy blood test can screen for multiple cancers (Photo courtesy of European Society for Medical Oncology)

Novel, High-Accuracy Blood Test Can Screen for Multiple Cancers

 A new targeted methylation-based assay has been developed that is able to screen blood samples for more than 20 types of cancer at all stages, including lung cancer, with high accuracy and it also correctly pinpoints the tissue of origin (TOO). More...
26 Nov 2019
Image: Axio Vert.A1 inverted microscope (Photo courtesy of Carl Zeiss)

Crohn's Disease-Associated Bacteria Tolerate Antibiotics

 Crohn's disease is a chronic disease that causes inflammation and irritation in the digestive tract. The disease is characterized by an imbalance in the intestinal microbiome. In particular, adherent-invasive Escherichia coli (AIEC) strains have been implicated in the disease. More...
26 Nov 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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