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Molecular Diagnostics

Image: Micrograph showing a human astrocyte growing in cerebral culture. An elevation in astrocyte protein markers was associated with an anti-inflammatory state in brains of patients with Alzheimer’s disease (Photo courtesy of Wikimedia Commons)

Large Proteomics Study Identifies New Fluid Biomarkers for Diagnosis of Alzheimer’s Disease

A recent study identified proteins and biological processes in brains from Alzheimer’s disease (AD) that may serve as diagnostic fluid biomarkers and potential therapeutic targets for the disease. More...
22 Apr 2020
Image: The lateral flow strips show three patient samples that are negative for BK virus (13,14,15) and three patient samples that are positive (16,17,18). Presence of the upper band indicates a positive test result (Photo courtesy of Dr. Michael Kaminski, Max Delbrück Center for Molecular Medicine)

A Non-Invasive Urine Test for Prediction of Kidney Transplant Failure

A non-invasive test that predicts potential kidney transplant failure combines the CRISPR gene editing tool with a lateral-flow visual readout procedure to analyse urine samples from transplantation recipients. More...
21 Apr 2020
Image: The Abbott RealTime CT/NG assay provides detection of Chlamydia trachomatis and Neisseria gonorrhoeae with proven clinical performance in sexually transmitted disease testing (Photo courtesy of Abbott Laboratories).

Real-Time Assay Evaluated for Two Sexually Transmitted Diseases

Chlamydia trachomatis and Neisseria gonorrhoeae are the two most commonly reported sexually transmitted infections (STIs) in the USA and the numbers of cases are increasing. C. trachomatis and N. gonorrhoeae infections in the rectum and pharynx are important extragenital reservoirs of infection. More...
21 Apr 2020
Image: Lauco crystal violet (LCV) colorimetric detection results of limit of detection (LoD) tests for the primer sets used for SARS-CoV-2 detection. 20U/reaction of reverse transcriptase were used (Photo courtesy of Korea Research Institute of Chemical Technology).

RT-LAMP Assay Developed for SARS-CoV-2

SARS-CoV-2 is the causative viral pathogen of COVID-19, and diagnosis of COVID-19 can be done through CT scan of suspicious patients and a confirmatory laboratory test is performed using published real-time quantitative polymerase chain reaction (RT-qPCR) methods. More...
20 Apr 2020
Image: The CELLSEARCH System is the first and only clinically validated, FDA-cleared system for identification, isolation, and enumeration of circulating tumor cells (CTCs) from a simple blood test (Photo courtesy of Menarini Silicon Biosystems).

Genetic Risk Score Predicts Prostate Cancer Drug Response

Metastatic castration-resistant prostate cancer is when the cancer has spread to parts of the body other than the prostate, and it is able to grow and spread even though drugs or other treatments to lower the amount of male sex hormones are being used to manage the cancer. More...
20 Apr 2020
Image: Histopathology of classic medulloblastoma in the brain showing a diffuse pattern of tumor growth with poor cellular differentiation, nuclear molding, and minimal indistinct cytoplasm (Photo courtesy of Adekunle M. Adesina, MD, PhD)

Novel Inherited Mutation Predisposes Children to Medulloblastoma

Cancer genomics has revealed many genes and core molecular processes that contribute to human malignancies, but the genetic and molecular bases of many rare cancers remains unclear. Genetic predisposition accounts for 5% to 10% of cancer diagnoses in children. More...
16 Apr 2020
Image: Colored transmission electron microscopy of the coronavirus. SARS-CoV-2–positive sputum and feces was found after conversion of pharyngeal samples in patients with COVID-19. This virus was isolated from the fecal matter of a patient with diarrhea (Photo courtesy of BSIP/UIG)

SARS-CoV-2 Found in Sputum/Feces After Negative Pharyngeal Specimens

The outbreak of coronavirus disease 2019 (COVID-19) has become a global public health problem. In the absence of a specific therapy or vaccine, timely diagnosis and the establishment of a sufficient isolation period for infected individuals are critical to containment efforts. More...
14 Apr 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.