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Molecular Diagnostics

Image: The structure of human hemoglobin with alpha and beta subunits in red and blue, respectively, and the iron-containing heme groups in green (Photo courtesy of Wikimedia Commons).

Abnormal Hemoglobin Levels Predict Risk of Developing Dementia

Both elevated and diminished levels of serum hemoglobin have been linked to an increased risk of developing various types of dementia including Alzheimer’s disease. More...
12 Aug 2019
Image: A circulating cancer cell (pink) attaches to carbon nanotube surface; white blood cells (blue) do not adhere and are later washed away (Photo courtesy of Curtis Sayers).

Liquid Biopsy Device Selectively Captures Circulating Tumor Cells

A new type of antigen-independent liquid biopsy captures device exploits the preferential attachment of circulating tumor cells (CTCs) to the surface of carbon nanotubes. More...
12 Aug 2019
Image: A micrograph showing amyloid beta (brown) in senile plaques of the cerebral cortex (upper left of image) and cerebral blood vessels (right of image) with immunostaining (Photo courtesy of Wikimedia Commons).

Amyloid Beta Blood Test Detects Asymptomatic Alzheimer’s Disease

An assay has been developed that determines the ratio of amyloid beta peptides in the blood and correlates with the accumulation of these Alzheimer’s disease risk factors in the brain. More...
12 Aug 2019
Image: A blood smear from a patient with non-Hodgkin lymphoma showing very large lymphocytes (Photo courtesy of Venngage).

BRCA2 Mutations Linked to Pediatric Non-Hodgkin Lymphoma Risk

Inherited mutations in BRCA1 and BRCA2 genes are most typically associated with an increased risk of developing breast and ovarian cancer. BRCA2 was the third most frequently mutated gene (14 occurrences) among 3,006 survivors of childhood cancer, with the highest number observed among survivors of lymphoma. More...
09 Aug 2019
Image: A photomicrograph showing tumor-infiltrating lymphocytes in colorectal carcinoma, which are suggestive of microsatellite instability, and may be seen in Lynch syndrome (Photo courtesy of Nephron).

Mutation Study Suggests Changes to Clinical Management

Lynch syndrome (LS) results from pathogenic variants in the mismatch repair (MMR) genes and is the most common hereditary cancer syndrome, affecting an estimated 1 in 300 individuals. More...
08 Aug 2019
Image: A diagram of a normal and a nerve cell affected by amyotrophic lateral sclerosis (Photo courtesy of Mayo Clinic).

Study Shows Heritability of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS), also known as motor neurone disease (MND) or Lou Gehrig's disease, is a specific disease that causes the death of neurons controlling voluntary muscles. More...
08 Aug 2019
Image: A scientist assembling the cartridge assay that distinguishes cancer from benign aspirates from mammographically suspicious breast lesions (Photo courtesy of Wanjun Ding).

Molecular Test Accurately Distinguishes Breast Tumors

A new laboratory test has been developed to identify chemical changes to a group of cancer-related genes that can accurately detect which breast tumors are cancerous or benign, and do it in far less time than gold-standard tests on biopsied breast tissue. More...
08 Aug 2019
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