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Molecular Diagnostics

Image: Micrograph of a liver sample with trichrome stain, showing cirrhosis as a nodular texture surrounded by fibrosis (collagen is stained blue) (Photo courtesy of Wikimedia Commons)

Glycosylated Serum Proteins Are Biomarkers for Severity of Liver Fibrosis

A recently developed assay was used to measure changes in the N-linked glycans on IgG subtypes in the blood, which can serve as surrogate markers of liver disease and may be able to replace the gold standard method, liver biopsy. More...
28 Apr 2022
Image: The XDive superfast qPCR platform (Photo courtesy of Star Array)

Automated Nucleic Acid Extraction/Superfast PCR Platform to Enable Analysis of POC PCR Tests in Minutes

An automated nucleic acid extraction/superfast PCR platform for the Point-of-Care testing (POCT) market could enable POC PCR tests to be analyzed in just minutes in doctor's offices, laboratories, and hospitals. More...
28 Apr 2022
Image: `3 Ct` to lay foundation for automated syndromic testing and make MDx more accessible (Photo courtesy of Seegene)

Seegene Unveils World's First Commercialized '3 Ct' PCR Assay

Seegene, Inc. (Seoul, Korea) has developed the world's first commercialized PCR assay applying '3 Ct' technology which can provide the Ct value of three targets in one channel without compromising sensitivity and specificity. More...
28 Apr 2022
Image: Rapid and disposable Theophylline sensor (Photo courtesy of SIT)

Paper-Based Sensor Could Pave Way for Bedside Therapeutic Drug Monitoring System

A new paper-based sensor to identify Theophylline (THO) is not only easy to use but also economical and can reduce the burden of drug analysis in developing countries. Additionally, its prototype can be used to develop a bedside therapeutic drug monitoring system. More...
27 Apr 2022
Image: PathScan Enabler IV Histology/Pathology Digital Slide Scanner (Photo courtesy of Meyer Instruments)

Immunohistochemistry-Guided Sequencing Finds Mutations in Most Cortisol-Producing Adenomas

Cushing syndrome (CS) represents a constellation of signs and symptoms associated with chronic and excessive exposure to glucocorticoids, from either endogenous endocrinopathies or, more commonly, from exogenous pharmacologic sources. More...
27 Apr 2022
Image: Blood test can differentiate preeclampsia from severe COVID-19 (Photo courtesy of Pexels)

Blood Test Differentiates Severe COVID-19 from Preeclampsia in Pregnant Women

A new study has identified indicators which enable differentiating between preeclampsia and severe COVID-19 in pregnant women , thus paving the way for a more accurate diagnosis for both diseases and a better risk assessment. More...
27 Apr 2022
Image: Bone marrow aspirate of a pediatric patient with acute lymphoblastic leukemia (Photo courtesy of St. Jude Children’s Research Hospital)

Pediatric Acute Lymphoblastic Leukemia Monitored by DNA Sequencing

Blood plasma sequencing appears to offer a noninvasive method for tracking disease clearance or persistence in children with acute lymphoblastic leukemia (ALL), along with the presence or absence of potentially infectious microbes. More...
26 Apr 2022
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