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Molecular Diagnostics

Image: The Oncotype DX specimen and collection kit for the Breast Cancer Recurrence Score Assay (Photo courtesy of Genomic Health).

21-Gene Recurrence Score Helps Radiation Decision-Making

 A new study shows that a test that physicians commonly used to guide chemotherapy treatment for post-breast cancer surgery patients may also help them decide whether radiation therapy may be of benefit. More...
21 Jan 2020
Image: Abnormal accumulation of tau protein in neuronal cell bodies (arrow) and neuronal extensions (arrowhead) in the neocortex of a patient who had died with Alzheimer's disease (Photo courtesy of Wikimedia Commons)

Acute Sleep Loss Triggers Increase in Plasma Levels of Tau Protein in Young Adults

 A team of Swedish researchers has found that acute sleep loss results in increased blood levels of t-tau protein, a key biomarker for nervous system disorders such as Alzheimer’s disease. More...
20 Jan 2020
Image: This micrograph depicts an atypical, enlarged lymphocyte found in the blood smear from a hantavirus pulmonary syndrome (HPS) patient. This large atypical lymphocyte is an example of one of the laboratory findings, which when combined with a bandemia, i.e., immature white blood cells, and dropping platelet count, is characteristic of HPS (Photo courtesy of Centers for Disease Control and Prevention)

Molecular Assays Developed for Hantavirus Pulmonary Syndrome

 Hantavirus Pulmonary Syndrome (HPS) is a serious and often fatal disease caused by viruses known as hantaviruses. These anthropozoonotic diseases comprising of two clinical entities: Hemorrhagic Fever with Renal Syndrome (HFRS), which occurs in the Old World, and Hantavirus Pulmonary Syndrome (HPS) in the New World. More...
16 Jan 2020
Image: Single nucleotide polymorphism: The upper DNA molecule differs from the lower DNA molecule at a single base-pair location (Photo courtesy of Marshall University).

Dual Nucleic Acid Template Assay Developed for Cancer

 Massive parallel sequencing or massively parallel sequencing is any of several high-throughput approaches to DNA sequencing using the concept of massively parallel processing; it is also called next-generation sequencing or second-generation sequencing. More...
16 Jan 2020
Image: Nextera XT DNA Library Preparation Kit (Photo courtesy of Illumina).

Extrachromosomal Circular DNA Identified in Maternal Plasma

 Circular cell-free DNA of both maternal and fetal origin can be identified in the plasma of pregnant women, pointing to a possible new type of biomarker for noninvasive prenatal testing (NIPT). More...
16 Jan 2020
Image: A dried flower bud of the Cannabis plant. The cannabis' flowers contain many different psychoactive compounds that are used for recreational or medicinal purposes (Photo courtesy of Wikimedia Commons)

A Sweat-Based On-Site Immunoassay for Monitoring Marijuana Use

 A novel sweat-based skin test enables on-site testing for tetrahydrocannabinol (THC), the main psychoactive component found in marijuana plants (Cannabis). More...
16 Jan 2020
Image: Schematic diagram of, circulating tumor DNA (ctDNA); circulating tumor cell (CTC); cell-free DNA (cfDNA) in the peripheral blood stream of a colon cancer patient (Photo courtesy of Oncology Letters)

Tumor DNA Platform Classifies Colorectal Cancer

 Most colorectal cancers are due to old age and lifestyle factors, with only a small number of cases due to underlying genetic disorders. Some of the inherited genetic disorders that can cause colorectal cancer include familial adenomatous polyposis and hereditary non-polyposis colon cancer; however, these represent less than 5% of cases. More...
15 Jan 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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