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Molecular Diagnostics

Image: Cartoon representation of the molecular structure of the hexokinase-2 (HK2) protein (Photo courtesy of Wikimedia Commons)

Liquid Biopsy Technique Detects Circulating Tumor Cells in Patients with Non-Small Cell Lung Cancer

A liquid biopsy technique based on hexokinase-2, a key enzyme in glucose metabolism, is able to detect circulating tumor cells (CTCs) in patients with non-small cell lung cancer (NSCLC). More...
16 Mar 2021
Image: Presence of lymphocytes within tubular epithelium is one of the pathological features of acute cellular rejection of a kidney transplant (Photo courtesy of Wikimedia Commons)

Analysis of Urinary Exosome RNA Can Diagnose Kidney Transplant Rejection

A panel of mRNA signatures derived from urinary exosomes was shown to be a powerful and noninvasive tool to screen for the body’s rejection of a kidney allograft (a transplant from a genetically non-identical donor). More...
15 Mar 2021
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Image: Micrograph of Whipple’s disease. This duodenal biopsy shows the characteristic feature of Whipple’s disease; foamy macrophages are present in the lamina propria cells (Photo courtesy of Nephron).

Whipple’s Disease Pathogen Found in International Diarrhea Patients

Tropheryma whipplei is the causative agent of Whipple’s disease. The organism has also been detected in the feces of healthy or asymptomatic persons and in the feces of patients with diarrhea. Symptoms tend to develop slowly over many years in most people with this disease. More...
11 Mar 2021
Image: Histopathology of Lewy bodies in the midbrain. A Lewy body in a melanized neuron from the substantia nigra. The Lewy body is the spherical body indicated by an arrow (Photo courtesy of Dr. Susan Daniel).

Five Genes Help Predict Lewy Body Dementia

Lewy body dementia usually affects people over 65 years old. Early signs of the disease include hallucinations, mood swings, and problems with thinking, movements, and sleep. Patients who initially have cognitive and behavioral problems are usually diagnosed as having dementia with Lewy bodies, but are sometimes mistakenly diagnosed with Alzheimer’s disease. More...
10 Mar 2021
Image: Histopathological image of sarcoidosis in a lymph node biopsy (Photo courtesy of Wikimedia Commons)

Low Lymphocyte Counts Linked to More Severe Sarcoidosis Inflammation

A recent paper identified unique phenotypes of sarcoidosis and demonstrated the relationship between these phenotypes and inflammatory activity, as measured by serologic markers of inflammation and avidity on 18FDG-PET/CT scan. More...
09 Mar 2021
Image: Exosomes are 30-150 nanometer extracellular vesicles containing various cargoes such as RNA and proteins (Photo courtesy of Wikimedia Commons)

Childrens’ Urinary MicroRNAs Predict Future Development of Heart or Kidney Diseases

A panel of microRNAs isolated from the urine of young children was shown to be able to predict the likelihood that a child would develop heart or kidney disease later in life. More...
08 Mar 2021
Image: Histopathologic image from a patient with Li Fraumeni syndrome showing accumulation of mutant TP53 in tumoral cells (Photo courtesy of Thierry Soussi, PhD).

Clinical Germline Testing Evaluated for Pediatric Cancer Patients

Pediatric cancer is rare, with fewer than 10,000 solid tumors diagnosed in children annually in the USA. Previous studies interrogating germline predisposition broadly across pediatric cancer types have found heritable germline predisposition in 8%–12% of patients. More...
04 Mar 2021
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