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Molecular Diagnostics

Image: The MiSeq benchtop sequencer enables targeted and microbial genome applications, with high-quality sequencing, simple data analysis, and cloud storage (Photo courtesy of Illumina)

Molecular Characterization of Microbiota in Cerebrospinal Fluid Using WGA

Hydrocephalus is a common cause of neurological disability in children. Cerebrospinal fluid (CSF) shunt placement allows children with hydrocephalus to survive and avoid ongoing brain injury. More...
02 Sep 2021
Image: A healthy human liver. A biomarker linked to the organ donor predicts the likelihood that a transplanted liver will be accepted or rejected by the recipient of the organ (Photo courtesy of Wikimedia Commons)

Donor-Linked Biomarker Predicts Likelihood of Liver Transplant Success

A recent paper identified a biomarker linked to the organ donor that predicts the likelihood that a transplanted liver will be accepted or rejected by the recipient of the organ. More...
31 Aug 2021
Image: Small round blue tumor cells found in the CSF of a patient with leptomeningeal disease from rhabdomyosarcoma (Photo courtesy of Pediatric Oncology)

Leptomeningeal Disease Diagnosed Using CSF Cell-Free DNA

Leptomeningeal disease (LMD) is a devastating complication of solid and liquid systemic and central nervous system malignant neoplasms. LMD, in which cancer metastasizes to the cerebrospinal fluid, occurs in 4% to 15% of cancer patients and is associated with poor survival, with untreated patients dying within four to six weeks. More...
26 Aug 2021
Image: The Agilent 1260 HPLC system (Photo courtesy of Agilent Technologies)

Various Serum Vitamin D Biomarkers Compared for Sarcopenia

Sarcopenia is an age-related clinical condition characterized by a gradual and generalized loss of skeletal muscle mass with a decrease in strength and physical capacity. It is considered to be one of the risk factors for adverse events in older people, including delirium, disability, institutionalization, and even death. More...
25 Aug 2021
Image: Two-dimensional structure of lactosylceramide (Lac-Cer). Lac-Cer levels in the circulation could have prognostic value for SLE patients with CVD (Photo courtesy of [U.S] National Library of Medicine)

Sphingolipids Are Prognostic Biomarkers for African American SLE Patients with Cardiovascular Disease

A recent study found that lactosylceramide levels may have a “predictive” value and sphingolipidomics have an added benefit to currently available tools for the early diagnosis and prognosis of African American systemic lupus erythematosus (SLE) patients with cardiovascular disease (CVD). More...
23 Aug 2021
Image: Representative example of amyloid-β plaques (Aβ1-42; brown staining; arrowheads) and neurofibrillary tangles (PHF1 antibody; blue staining; arrow) in the frontal cortex of a 46-year-old person with Down syndrome and end-stage Alzheimer disease. (Photo courtesy of University of California, Irvine).

CSF biomarkers Compared for Down Syndrome and Inherited Alzheimer’s

Although most people with Down’s syndrome will experience brain changes as they age, not everyone will develop Alzheimer’s disease or another type of dementia. Whilst having Down’s syndrome does put a person at increased risk, estimated at 1 in 3 people in their 50s, and closer to 2 in 3 aged over 60, it is not inevitable for all. More...
19 Aug 2021
Image: Gross pathology of idiopathic cardiomyopathy. Opened left ventricle of heart shows a thickened, dilated left ventricle with subendocardial fibrosis manifested as increased whiteness of endocardium (Photo courtesy of [U.S.] Centers for Disease Control and Prevention)

More Complete Genetic Screening Benefits Cardiovascular Disease Patients

Results of a pilot study suggested that information obtained by comprehensive genetic testing would benefit treatment of patients suffering from a wide range of cardiovascular diseases. More...
17 Aug 2021
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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