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Molecular Diagnostics

Image: A) NDUFS1 immunohistochemistry staining of prostate cancer (PCa) tissue microarray (TMA) samples and B) ATP5O immunohistochemistry staining of PCa TMA samples. Staining intensity as per number. Scale bar = 100 µm (Photo courtesy of Medical University of Vienna)

Novel Protein Biomarkers Identified for Prostate Cancer Aggressiveness

Prostate cancer is the most commonly diagnosed cancer in men and is among the top five causes of cancer-related death. In most cases, prostate cancer can be successfully treated but there is a group of patients who suffer an aggressive course and often fatal outcome. More...
05 Jan 2022
Image: The 21 HPV GenoArray Diagnostic Kit for the rapid and accurate HPV genotyping macro array for 21 human papillomavirus identification (Photo courtesy of Hybribio Ltd)

Menstrual Blood Testing With Capture Sequencing Detects High-Risk Human Papillomavirus

Persistent infection of high-risk human papillomavirus (hrHPV) is associated with various HPV-related pre-cancers and cancers. In recent years, HPV testing has gradually become the primary method for cervical cancer screening. More...
04 Jan 2022
Image: Crystallographic structure of sex hormone binding globulin (SHBG) (Photo courtesy of Wikimedia Commons)

Sex Hormone–Binding Globulin Is a Biomarker for Cardiovascular Disease Risk Independent of Total Testosterone Concentration

The blood protein sex hormone–binding globulin (SHBG) has been shown to be a biomarker that predicts greater risk of myocardial infarction and lower risk of ischemic stroke and heart failure in men between the ages of 40 and 69. More...
03 Jan 2022
Image: FastDNA Spin Kit for Soil quickly and efficiently isolates PCR-ready genomic DNA (Photo courtesy of MP Biomedicals)

Parkinson’s Disease Patients Have More Inflammatory Bacteria in Their Noses

Parkinson’s disease (PD) is a complex neurodegenerative disease characterized by nigrostriatal degeneration resulting in bradykinesia, rigidity, tremor, and gait dysfunction. Non-motor symptoms are also typically present, including depression, constipation, and alteration of smell. Diminished sense of smell (hyposmia), is a common hallmark of prodromal PD. More...
29 Dec 2021
Image: The synaptic sheddome: protein ectodomains shed into the cerebrospinal fluid (Photo courtesy of Dr. Peter Penzes, Northwestern University)

Certain Protein Ectodomains in Cerebrospinal Fluid Are Diagnostic Biomarkers for Autism

Abnormally low levels of a protein biomarker, which can be detected in the cerebrospinal fluid (CSF), have the potential to be the basis for diagnosis of autism and related neurological disorders. More...
27 Dec 2021
Image: The EZ1 Advanced XL performs automated nucleic acid purification for a wide range of sample types relevant for molecular diagnostics, human identity testing, and gene expression analysis (Photo courtesy of Qiagen).

Bacterial Communities Diverge in The Lower Airways of CF Children

Chronic airway infection and inflammation resulting in progressive, obstructive lung disease is the leading cause of morbidity and mortality in people with cystic fibrosis (CF). Culture-independent, molecular approaches have broadened the view from a few individual pathogens to more complex and dynamic polymicrobial communities. More...
23 Dec 2021
Image: Histopathology of a typical neuroblastoma with rosette formation (Photo courtesy of Dr. Mark Applebaum, MD)

Intratumor Heterogeneity Analyzed in Neuroblastoma

Neuroblastoma is the most common solid pediatric tumour, accounting for 15% of cancer-related deaths in early childhood and especially for patients directly diagnosed with high-risk neuroblastoma have a poor prognosis. More...
22 Dec 2021
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