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Molecular Diagnostics

Image: Histopathology of adenocarcinoma of the prostate on needle biopsy consisting of small glands with amphophilic cytoplasm (Photo courtesy of Professor Jonathan I. Epstein, MD)

Genetic Clues Link Lipoprotein A to Prostate Cancer Risk

Some factors associated with higher risk of prostate cancer (PCa) cannot be modified, such as older age and being of African descent. Meanwhile, other risk factors for the aggressive form of the disease, such as smoking and obesity, can potentially be modified. More...
07 Feb 2022
Image: Gene fusions play a key role in the formation and spread of nearly 20% of all human cancers. This schematic shows the ways a fusion gene can occur at a chromosomal level (Photo courtesy of Wikimedia Commons)

RNA Sequencing Improves Gene Fusion Detection for Childhood Cancer Diagnostics

Analysis of whole tumor RNA in children with cancer significantly increases the detection of gene fusions, which can provide information concerning the exact cancer type, the aggressiveness of the tumor, and the possible benefit of targeted drugs. More...
07 Feb 2022
Illustration

Microfluidic Gated Device for Extraction of Cell-Free DNA Could Help Accurately Diagnose Infections from Small Blood Sample

Scientists have developed a microfluidic device for the purification of tuberculosis genomic DNA fragments from human-plasma samples. More...
07 Feb 2022
Illustration

New High-Throughput Microscopy and Machine Learning Systems Identify and Classify DNA Repair Factors

A team of researchers has developed high-throughput microscopy and machine learning systems that can identify and classify DNA repair factors. More...
04 Feb 2022
Image: Schematic diagram of image-enabled cell sorting, developed at BD Biosciences and  tested by European Molecular Biology Laboratory (Photo courtesy of BD Bioscience)

High-Speed Fluorescence Image-Enabled Cell Sorting Tested

Cell sorting through flow cytometry is a technique that enables scientists to identify and sort individual cells based on specific characteristics of each cell in order to study them in more detail, evaluate how each cell may react to a new drug or perform other single cell studies. More...
03 Feb 2022
Image: SNRPN (Small nuclear ribonucleoprotein-associated protein N). SNRPN-methylation is used to detect imprinting errors on chromosome 15 (Photo courtesy of Wikimedia Commons)

Novel Blood Test Diagnoses Newborns with Rare Genetic Disorders

A team of Australian researchers has developed a test to screen newborns for three rare genetic disorders simultaneously. More...
01 Feb 2022
Image: The NovaSeq 6000 Sequencing system (Photo courtesy of Illumina)

Transcriptomic Analysis Reveals Proinflammatory Signatures Associated with AML Progression

Acute myeloid leukemia (AML) is believed to arise through a combination of genetic alterations and aberrant gene expression patterns caused by genetic and epigenetic changes, which in their composition also determine AML progression and therapy resistance. More...
01 Feb 2022
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.