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Molecular Diagnostics

Image: Applied Biosystems 7900HT Sequence Detection System is designed for automated, high-throughput detection of fluorescent PCR-related chemistries (Photo courtesy of Grizzly Analytical)

BDNF Risk Variant Linked to Brain Inflammation in RRMS Patients

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) that is nowadays representing one of the main causes of disability in young people. The clinical course of MS is highly variable and reflects the complex pathogenesis characterized by inflammation and neurodegeneration already detectable in the initial stages of the disease. More...
28 Mar 2022
Image: An astrocyte cell grown in tissue culture stained with antibodies to GFAP and vimentin (Photo courtesy of Wikimedia Commons)

Blood Levels of Glial Fibrillary Acidic Protein Predict Dementia Risk in Older Mexican Americans

A protein biomarker in the blood was identified that may help predict the likelihood of developing dementia among Mexican Americans over the age of 50. More...
28 Mar 2022
Image: Oral squamous cell carcinoma (Photo courtesy of 123rf.com)

A Minimally Invasive PCR Test for Diagnosis of Oral Cancer

A team of British researchers has adapted the PCR method - now well known for the detection of the COVID-19 virus - for the precise diagnosis of oral squamous cell carcinoma (mouth cancer). More...
25 Mar 2022
Image: New rapid diagnostic test to detect signs of a stroke or other brain injury (Photo courtesy of TETDiagnostics)

Enzyme-Based Point-of-Care Test Could Rapidly Identify Stroke Patients upon Arrival at Hospital

Researchers at Cornell University (Ithaca, NY, USA) have developed a new test that could rapidly identify stroke patients upon arrival at the hospital, so that more patients could receive a CT scan and the clot-dissolving medicine tPA within the critical window. The researchers plan to develop this enzyme-based technology into a range of diagnostic tests that can be performed anywhere using a handheld device. Their initial research has shown that the test effectively diagnoses stroke and concussions. More...
25 Mar 2022
Image: Researchers have validated a new antibody test to diagnose multiple sclerosis (MS) (Photo courtesy of Mayo Clinic)

New Antibody Test Diagnoses Multiple Sclerosis in 20 Minutes

Researchers at Mayo Clinic (Rochester, MN, USA) have validated a new antibody test to diagnose multiple sclerosis (MS) that measures kappa immunoglobulin free light chains in cerebrospinal fluid. The researchers conclude the test is a valid alternative to a commonly used test to detect oligoclonal bands in cerebrospinal fluid. More...
25 Mar 2022
Image: Various kinds of extracellular vesicles (EVs) (Photo courtesy of American Physiological Society)

An Extracellular Vesicle-based Liquid Biopsy for Early Cancer Detection

An extracellular vesicle-based liquid biopsy method was shown to be a promising approach for the diagnosis of stages I and II pancreatic, ovarian, and bladder cancers. More...
24 Mar 2022
Image: Representation of a breast cancer cell (Photo courtesy of Anne Weston, Francis Crick Institute via the Wellcome Collection)

Cerebrospinal Fluid Liquid Biopsy for Diagnosis of Metastatic Breast Cancer

A liquid biopsy technique that detects cell-free tumor DNA (ctDNA) in the cerebrospinal fluid (CSF) offers the possibility for early and definitive diagnosis of leptomeningeal metastasis of breast and other cancers. More...
23 Mar 2022
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.