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Molecular Diagnostics

Image: Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis (Photo courtesy of Dr. Christopher Wiley)

Novel Lipid Biomarker Detects Senescent Cells

A recent paper identified a lipid biomarker indicative of cellular senescence and described a method to evaluate its effect on the molecular events that lead to senescence. More...
13 Apr 2021
Image: The EZ DNA Methylation-Direct Kit (Photo courtesy of Zymo Research)

Leukocyte Epigenomics and Artificial Intelligence Predict Late-Onset Alzheimer’s Disease

Alzheimer’s Disease (AD) is the most common form of age-related dementia, accounting for 60%–80% of such cases. The disorder causes a wide range of significant mental and physical disabilities, with profound behavioral changes and progressive impairment of social skills. More...
12 Apr 2021
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Image: APM2 overexpression increases the expression of the ERCC6L gene (Photo courtesy of Niigata University)

A Protein Biomarker Aids Cancer Patients by Controlling the Dosage of Highly Toxic Cisplatin

A team of Japanese investigators has identified a protein biomarker that may help clinicians control the dosage of the highly toxic chemotherapeutic drug cisplatin. More...
12 Apr 2021
Image: The BD FACSAria III sorter is equipped with five lasers, 17 fluorescence channels and two channels for Forward Scatter and Side Scatter (Photo courtesy of BD Biosciences)

Genome Sequencing Identifies Myeloma Precursor Disease with Progression Risk

Multiple myeloma (MM) is the second most common hematological malignancy and is consistently preceded by the asymptomatic expansion of clonal plasma cells, termed either monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SMM). More...
08 Apr 2021
Image: Bone marrow aspirate from a child with a mediastinal tumor shows an invasion with neuroblastoma cells and characteristic images of neuropile threads (Photo courtesy of Mohammed Bensalah, MD, Amina Lyagoubi, and Rachid Seddik)

Single-Cell Transcriptomic Analysis Traces Neuroblastomas to Developing Adrenal Neuroblasts

Neuroblastoma is the most common cancer in infants and the third-most common cancer in children after leukemia and brain cancer. Approximately one in every 7,000 children is affected at some time and about 90% of cases occur in children less than five years old, and it is rare in adults. More...
07 Apr 2021
Image: Artificial intelligence monitoring for HPV (AIM-HPV) device for point-of-care HPV testing (Photo courtesy of Ismail Degani, Center for Systems Biology, Massachusetts General Hospital)

Advances in High-Tech Methods for Cervical Cancer Screening

Cervical cancer, which is almost always caused by human papillomavirus (HPV), is the world's fourth-most common cancer, with more than 500,000 cases diagnosed annually. More...
06 Apr 2021
Image: The DNA Genotek CP-190 saliva self-collection kits (Photo courtesy of Kyodo International Inc)

Salivary Diagnostic Signatures of Concussion Found in Male Athletes

Sport-related concussion is defined as a traumatic brain injury induced by biomechanical forces that typically results in the rapid onset of short-lived impairment of neurological function that resolves spontaneously. A high percentage of cases may go misdiagnosed or unidentified. More...
05 Apr 2021
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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