We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

FDA-Cleared Automated Cell Counter for CSF Launched at AACC 2016

By LabMedica International staff writers
Posted on 04 Aug 2016

Image: The GloCyte system delivers highly accurate and precise total nucleated cell and red blood cell counts using a novel combination of technologies (Photo courtesy of Advanced Instruments).

Image: The GloCyte system delivers highly accurate and precise total nucleated cell and red blood cell counts using a novel combination of technologies (Photo courtesy of Advanced Instruments).

The system provides superior accuracy of low cell counts in cerebrospinal fluid samples. It is being introduced at the AACC Annual Scientific Meeting & Clinical Lab Expo (July 31 - August 4; Philadelphia, PA, USA). Linda Sandhaus, MD, University Hospitals Case Medical Center, presented a poster (#A-290) on August 2 titled GloCyte: A New Automated Technology for Cerebrospinal Fluid (CSF) Cell Counts.

Advanced Instruments, Inc. (Norwood, MA, USA) has received 510(k) clearance from the US Food & Drug Administration (FDA) to market its GloCyte Automated Cell Counter System and GloCyte Low and High Level Controls. The patented GloCyte System is intended to provide a quantitative determination of red blood cells (RBCs) and total nucleated cells (TNCs) in CSF collected from adult and pediatric patients. Currently, low cell counts often present a challenge to standard methods.

“To date, there has not been a way to provide dependable, low cell counts,” said John Coughlin, president and CEO, Advanced Instruments, “We use a novel combination of fluorescence, microscopy with digital image analysis principles, highly specific reagents, and an intelligent counting algorithm to provide accurate and precise cell counts. We are very excited as this marks a major achievement in giving laboratories a new way to obtain reliable and timely CSF results.”

Additional benefits of the GloCyte System are that the test requires only 30 microliters of sample per test, it uses disposable test cartridges ensuring no sample carryover and easy disposal, and it includes built-in quality control of Levey-Jennings charts and an audit table. The company expects to begin GloCyte shipments in September 2016.

Related Links:
Advanced Instruments

Visit expo >

Platinum Member

Automated Coagulation Analyzer

Hemolumi H6

Gold Member

NEW PRODUCT : SILICONE WASHING MACHINE TRAY COVER WITH VICOLAB SILICONE NET VICOLAB®

REGISTRED 682.9

Platinum Member

Integrated Biochemical & Immunological System

Biolumi CX Solution X10+C10

Portable POCT Blood Gas Analyzer

BD100

Latest AACC 2016 News

Channels

Clinical Chemistry

view channel

Image Credit: iStock

Blood Protein May Help Identify Treatment-Resistant Psychosis

Psychotic disorders, including schizophrenia, are diagnosed primarily through assessment of symptoms and behaviors such as hallucinations, delusions, and disordered thinking. Treatment-resistant psychosis... Read more

Image: Schematic illustration of the operating principle of the enzyme-reaction-based highly sensitive biosensor (ESGNS) (Credit: Chihyun Kim, Wonjun Jo, Dayoung Chang, et al. Enzymatic sialylation–driven gold nanostructured platform for rapid and selective detection of sialic acid–deficient transferrin. Chemical Engineering Journal, 2026. https://doi.org/10.1016/j.cej.2026.182244)

Electrochemical Biosensor Rapidly Detects Cerebrospinal Fluid Leaks

Cerebrospinal fluid surrounds the brain and spinal cord and helps protect them from physical impact. After severe head trauma or brain surgery, it can leak through skull defects and drain from the nose or ears.... Read more

Blood Protein Panel Supports Monitoring of Treated Celiac Disease

Celiac disease is an autoimmune condition in which gluten triggers intestinal inflammation that can damage the gut and impair nutrient absorption. Even with a gluten-free diet, some patients may continue... Read more

Hemoglobin Levels May Help Signal Long-Term Dementia Risk

Dementia is a growing health challenge in aging societies, with limited treatment options and no cure. Identifying long-term risk remains difficult, particularly when specialist scans or emerging biomarkers... Read more

Molecular Diagnostics

view channel

Image: Seye Oladeji, graduate student and first author, holds up an example of a detection assay. (Photo courtesy of Rice University/Jared Jones)

New RNA Detection Tool Shows Promise for HIV and Other Viral Testing

RNA viruses such as human immunodeficiency virus (HIV) require assays that can detect very low levels of viral genetic material. Clinical and environmental testing can also expose enzymes to harsh assay... Read more

Image: The platform is designed to isolate extracellular vesicles originating from a selected tissue, with an initial focus on those released by hepatocytes in the liver. (Photo courtesy of Mursla Bio)

Tissue-Specific Vesicle Isolation Expands Molecular Insights Into Liver Disease

Liver disease can produce overlapping molecular signals from cirrhosis and hepatocellular carcinoma, complicating blood-based analysis. Liquid biopsy approaches that examine extracellular vesicles face... Read more

Image: GenomeNext uses a pangenome reference to better represent human genetic diversity and improve variant detection, while GenomeReveal integrates RNA analysis to help interpret certain DNA findings (Photo courtesy of Ambry Genetics)

Whole Genome Sequencing Solution Targets Unsolved Rare Disease Cases

Rare diseases often present persistent diagnostic challenges for patients and families. Many patients undergo years of testing without receiving a diagnosis, and even comprehensive genetic testing can... Read more

Study Shows How Genome Reference Bias Can Mislead Preventive Testing

Whole-genome sequencing is expected to play a growing role in preventive and predictive medicine, but accurate interpretation remains a major diagnostic challenge. The approach requires comparing billions... Read more

Hematology

view channel

Image Credit: Adobe Stock

New Donor Genetic Marker May Help Predict Stem Cell Transplant Success

Donor selection for hematopoietic stem cell transplantation plays a major role in relapse risk and survival for patients with blood cancers and other blood disorders. Despite advances in genotyping, uncertainty... Read more

Image Credit: American Society of Hematology

Updated Ferritin Thresholds Improve Detection of Iron Deficiency

Iron deficiency is one of the most common health conditions worldwide, yet its nonspecific symptoms can delay diagnosis for months. Variation in testing practices and ferritin thresholds may contribute... Read more

New Automated Hemostasis Systems Become Available Across US Laboratories

Hemostasis testing supports critical decisions in surgery, anticoagulation management, and the evaluation of bleeding and thrombotic disorders, but laboratories continue to face rising volumes and complex... Read more

Image: Acute myeloid leukemia is an aggressive blood cancer in which relapse remains a major challenge, making MRD detection critical for risk assessment and treatment planning (Image Credit: Shutterstock)

Variation in AML Residual Disease Testing Prompts Push for Standardization

Acute myeloid leukemia (AML) is an aggressive blood cancer in which relapse after therapy remains a persistent challenge, making measurable residual disease (MRD) detection central to risk assessment and... Read more

Immunology

view channel

FDA Approval Adds Automated Testing Option for Parvovirus B19 Serology

Human Parvovirus B19 is a highly contagious erythrovirus transmitted mainly through respiratory droplets and close contact. Diagnosis relies on IgM antibodies to detect active infection and IgG antibodies... Read more

Blood-Based Immune Aging Map Could Help Spot Disease Risk Earlier

Chronological age does not always reflect immune health or future disease risk. Two adults of the same age can have immune systems that age very differently, with some remaining resilient while others... Read more

Blood-Based Immune Signal Could Reveal Lung Cancer Risk Before Tumors Develop

Lung cancer remains difficult to detect before symptoms appear, when advanced disease is harder to treat. In the U.K., about 32,800 people die from lung cancer each year, and only 11.1% of those diagnosed... Read more

Prototype Point-of-Care Test Aims to Improve Neonatal Sepsis Diagnosis

Neonatal sepsis remains difficult to diagnose because early signs can resemble other newborn conditions. Diagnostic delays may increase the risk of complications, death, long-term adverse outcomes, and... Read more

Microbiology

view channel

Oral and Lung Microbiome Changes Linked to Severe Long Covid Symptoms

Long Covid can involve persistent respiratory, cognitive, and gastrointestinal symptoms after acute infection, creating a difficult diagnostic and management challenge. Because COVID-19 initially affects... Read more

Image: A health worker from the Mfou District Hospital collects a blood sample for the study (Photo courtesy of Sandrine Nsango, PhD)

Study Finds Distinct Malaria Parasites Linked to Sickle Cell Trait Protection

Malaria remains one of the world’s deadliest infectious diseases and has affected humans throughout recorded history. In regions where malaria is common, human genetics have been shaped by the sickle cell... Read more

Rapid Urine Test Aids Diagnosis of Invasive Aspergillosis

Invasive aspergillosis is an uncommon mold infection in the general population but can pose serious risks for people with weakened immune defenses. Diagnosis can be difficult because existing approaches... Read more

Image: Schematic overview of the CRISPR-Assisted Nanodroplet-pairing Platform for Differential Identification of NTM (CANDI). The platform combines broad-range amplification using conserved regions of the 16S and 23S rRNA genes with species-specific CRISPR recognition. Fluorescence-coded CRISPR droplets are paired with sample droplets containing amplified products, enabling multiplexed target recognition and signal decoding (Image Credit: Yiwen Yang, Jingsong Xu, Dakang Xu)

Nanodroplet CRISPR Technology Supports Rapid, Multiplexed Mycobacterial Identification

Mycobacterial infections are difficult to diagnose because closely related species can have different clinical and therapeutic implications. Nontuberculous mycobacteria (NTM) are increasingly recognized... Read more

Pathology

view channel

Molecular Testing Refines Barrett’s Esophagus Progression Risk Beyond Biopsy Findings

Barrett’s esophagus is a precancerous condition associated with increased risk of esophageal adenocarcinoma. Routine endoscopic biopsy findings guide surveillance and therapy, but histopathology may not... Read more

Image: Overview of the multiple-instance learning (MIL) workflow, in which each TMA core image is represented as a bag of patches that are encoded and aggregated to generate a slide-level prediction. (Giner F, Pastor-Naranjo Á, Meseguer P, et al. International Journal of Molecular Sciences, 2026. DOI: 10.3390/ijms27156864)

AI Histopathology Tool Distinguishes Ewing Sarcoma for Diagnosis

Ewing sarcoma is a rare malignant tumor that mainly affects children, adolescents, and young adults. It usually arises in bone but can also develop in soft tissue, where its microscopic appearance may... Read more

Rapid Mass Spectrometry Test May Aid Glioma Margin Decisions

Glioma brain tumors are highly infiltrative and can extend into nearby healthy brain tissue, making tumor margins difficult to define during surgery. Residual tumor cells may contribute to recurrence and... Read more

Genomic Classifier Predicts Benefit From Adding Hormone Therapy to Salvage Prostate Radiation

Men who have undergone prostatectomy for prostate cancer may later develop a detectable or rising prostate-specific antigen, prompting salvage radiation therapy. A key challenge is determining who is most... Read more

Technology

view channel

Laser-Based Swab Analysis Shows Promise for Detecting Disease-Linked Odor Patterns

Disease-related changes in volatile organic compounds can alter body odor, producing measurable patterns in exhaled breath and bodily fluids. Current analytical methods can be complex, time-consuming,... Read more

Image: Antibody-coated microscopic beads are introduced into a tiny flow channel containing blood plasma. Laser irradiation enhances their interaction with CEACAM-5, a colorectal cancer biomarker, causing the beads to assemble and generate a detectable signal. (Image Credit: Figure reproduced from Iida et al., Nanoscale Horizons(2026), DOI: 10.1039/d6nh00017g. Licensed under CC BY-NC 4.0.)

Laser-Enhanced Assay Boosts Sensitivity for Colorectal Cancer Biomarker Detection

Colorectal cancer is the third most commonly diagnosed cancer and the second leading cause of cancer-related death worldwide. Early detection remains critical, but cancer biomarkers can produce only faint... Read more

$Image: OGT\'s SureSeq next‑generation sequencing portfolio, designed for use with the Hamilton NGS STAR Line (Photo courtesy of Hamilton Company)$

New Automation Workflow Streamlines NGS Library Preparation for High-Volume Labs

Demand for next-generation sequencing (NGS) continues to rise as laboratories process growing sample volumes, yet library preparation remains labor-intensive and a frequent source of variability.... Read more

Image: ADLM recommends that emerging AI tools follow the same professional oversight, quality, validation, and monitoring standards as traditional clinical testing within CLIA’s existing framework (Image Credit: Adobe Stock)

ADLM Calls for CLIA Updates to Support Safe AI Use in Laboratory Medicine

Clinical laboratories increasingly use artificial intelligence to verify, interpret, and report results, but safeguards under the Clinical Laboratory Improvement Amendments (CLIA) were designed in 1992.... Read more

Industry

view channel

Agilent Acquisition of Proscia to Advance AI-Enabled Digital Pathology Workflows

Agilent Technologies Inc. has entered into a definitive agreement to acquire Proscia, a provider of digital pathology software for clinical and life-sciences customers. The all-cash transaction is valued... Read more

Diazyme Expands Chemistry Testing Portfolio With Alfa Wassermann Acquisition

Diazyme Laboratories, Inc., based in Poway, California, has acquired the business of Alfa Wassermann Diagnostic Technologies LLC from CARR Biosystems. Alfa Wassermann Diagnostic Technologies is a U.... Read more

Digital Pathology Collaboration Expands Laboratory Access to AI-Driven Diagnostics

Aiforia Technologies Plc (Helsinki, Finland) has entered into a commercial agreement with PathAI (Boston, MA, USA), a member of the Roche Group and developer of the AISight Dx Image Management System.... Read more

$Image: Natera\'s MCED assay analyzes cell-free DNA in blood to screen for multiple cancers (Image Credit: Adobe Stock)$

Multi-Cancer Screening Blood Test Gains FDA Breakthrough Designation

Natera Inc.’s (Austin, TX, USA) multi-cancer early detection (MCED) assay has received Breakthrough Device designation (BDD) from the U.S. Food and Drug Administration (FDA). The assay analyzes cell-free... Read more