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Immunology

Image: Histopathology of Leptomeningeal Melanoma Metastases: tumor cell clusters in the subarachnoid space in a brain biopsy (Photo courtesy of selbst).

Molecular Characteristics of Leptomeningeal Melanoma Metastases Identified

 Patients with advanced melanoma who develop metastases in the leptomeninges, the fluid filled membranes surrounding the brain and spinal cord, have an extremely poor prognosis. Most patients only survive for eight to 10 weeks after diagnosis. More...
20 Jan 2020
Image: The Attune NxT Acoustic Focusing Cytometer is ideal for immunophenotyping and signaling studies, cell cycle analysis, detection of rare events, stem cell analysis, cancer and apoptosis studies, microbiological assays, and more (Photo courtesy of Thermo Fisher Scientific)

Diagnostic Assay Identifies Leukemic Stem Cells

 Acute myeloid leukemia (AML) is the most common type of leukemia in adults. It is characterized by the pathological expansion of immature cells (myeloblasts) that invade the bone marrow and expand into the blood, affecting the production of the rest of the healthy cells. More...
15 Jan 2020
Image: Synergy H1 Hybrid Multi-Mode Reader is a configurable microplate reader (Photo courtesy of BioTek)

Higher Female TSH Associated With Lower Mannan-Binding Lectin

 Mannan-binding lectin (MBL) is a main component of the lectin pathway of the complement system. Lower MBL levels are associated with, among other conditions, hypothyroidism and adverse pregnancy outcomes. More...
15 Jan 2020
Image: The NEO Iris is a fully automated immunohematology analyzer for in vitro diagnostic testing of human blood (Photo courtesy of Immucor)

Glycoprotein-Specific Direct Platelet Autoantibody Testing in Immune Thrombocytopenia

 Autoantibodies directed against platelet glycoproteins have long been accepted as a major pathophysiologic mechanism in immune thrombocytopenia (ITP), but platelet autoantibody (PA) testing has previously shown poor sensitivity for ITP diagnosis. More...
14 Jan 2020
Image: The Roche cobas electro-chemiluminescence immunoassay kit for alpha-fetoprotein (AFP) (Photo courtesy of Toliopoulos Diagnostics).

Plasma HSP90α Levels Used for Detection of Hepatocellular Carcinoma

 Liver cancer is composed mostly of primary liver cancers and secondary liver cancers. Hepatocellular carcinoma (HCC), as the major type of primary liver cancer, is the fifth most common tumor worldwide and the third leading cause of cancer mortality, responsible for 745,500 cancer deaths annually. More...
14 Jan 2020
Image: The ABI PRISM 3500 Genetic Analyzer Platform (Photo courtesy of Applied Biosystems)

Multiplex Nested Polymerase Chain Reaction Developed for Congenital Infections

 Infections are the leading cause of perinatal mortality in low- and middle-income countries, which have a higher prevalence of infections, and are responsible for 50% of infant deaths in the first year of life. Definitive diagnosis of congenital and perinatal infections is largely dependent upon the results of laboratory tests. More...
13 Jan 2020
Image: Examples of negative and positive Chagas Stat-Pak RDT results. From left to right, negative, weakly positive, and strongly positive Stat-Pak results are shown (Photo courtesy of Yves Jackson)

Rapid Diagnostic Tests for Chagas Disease Field Evaluated

 Chagas disease, caused by infection with the protozoan parasite Trypanosoma cruzi, is the neglected tropical disease exerting a highest burden in the Western hemisphere. It is estimated that there are around seven million people affected worldwide, the majority of them living in Latin America where the insect vectors that transmit the infection are endemic. More...
08 Jan 2020
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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