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Molecular Diagnostics

Image: Dark field microscopy of a culture of blood in EMJH semisolid media showing spirochetes with morphology compatible with Leptospira (Photo courtesy of Alejandro Llanes).

Multivariable Diagnostic Prediction Score Validated for Leptospirosis

 Leptospirosis is a bacterial disease that affects humans and animals. It is caused by bacteria of the genus Leptospira. In humans, it can cause a wide range of symptoms, some of which may be mistaken for other diseases. More...
30 Jan 2020
Image: The DS-11 Series of Spectrophotometers are used to perform fast quantification of nucleic acids and proteins (Photo courtesy of DeNovix).

Homologous Recombination Defects Prevalent in African-American Cancer Patients

 In the USA, African-Americans have the highest cancer incidence and lowest survival across multiple cancer types. The reasons for these persistent trends are not clear. More...
28 Jan 2020
Image: Ball-and-stick model of the fentanyl molecule in the crystal structure of fentanyl citrate-toluene solvate (Photo courtesy of Wikimedia Commons)

Siemens Healthineers Introduces Autoanalyzer Assay for Monitoring Fentanyl Usage

 A recently introduced diagnostic test for use on clinical chemistry autoanalyzers measures the levels of the opioid drug fentanyl and its primary metabolite norfentanyl. More...
28 Jan 2020
Image: Optic nerve in advanced glaucoma disease (Photo courtesy of Wikimedia Commons)

Genetic Risk Score Detects Glaucoma and Predicts Progression of the Disease

 Establishment of a glaucoma polygenic risk score (PRS) will facilitate the development of a personalized approach for earlier treatment of high-risk individuals, with less intensive monitoring and treatment being possible for lower-risk groups. More...
28 Jan 2020
Image: Acute Myeloid Leukemia: The blasts are medium to large in size and have an elevated nuclear: cytoplasmic ratio. The nuclear chromatin is fine and there are prominent nucleoli. Frequent blasts show indented or “cup-shaped” nuclear contours (Photo courtesy of Elizabeth Courville, MD).

Bone Marrow Donors May Transfer Pathogenic Mutations to Patients

 Clonal hematopoiesis of indeterminate potential, or CHIP, is characterized by the presence of mutant hematopoietic stem cell clones in the bone marrow without overt signs of disease. More...
27 Jan 2020
Image: Photomicrograph of Rickettsia conorii in Vero cells (red rods; magnification ×1,000) (Photo courtesy of Wikimedia Commons)

Identification of Rickettsial Biomarker Facilitates Early Diagnosis of Tick-borne Spotted Fevers

 A protein biomarker has been identified that enables the rapid and specific early diagnosis of tick-borne rickettsial diseases such as Rocky Mountain spotted fever and Mediterranean spotted fever. More...
27 Jan 2020
Image: Photomicrograph of a sputum specimen showing the presence of numerous Mycobacterium tuberculosis bacteria (Photo courtesy of [U.S.] Centers for Disease Control and Prevention)

Genetic Biomarkers Detect Incipient Tuberculosis, Predict Progression of the Disease

 A panel of genetic biomarkers in samples of whole blood has been confirmed as a useful biomarker for the detection of incipient tuberculosis (TB). More...
27 Jan 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.