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Molecular Diagnostics

Image: Histopathology of colon adenocarcinoma composed of chaotic glandular structures that are lined by one or more rows of cancer cells with or without mucus production (Photo courtesy of the Johns Hopkins University).

Novel Blood Test Detects Colorectal Cancer Recurrence Earlier

Colorectal cancer is one of the leading causes of cancer-related deaths worldwide, accounting for more than 600,000 deaths each year. When diagnosed early, before cancer has spread, the relative five-year survival rate for CRC is 90%, but only about 4 out of 10 CRC cases are detected early.  More...
05 Apr 2016
Image: Schematics of the three biomarker myChoice homologous recombination deficiency (HRD) assay (Photo courtesy of Myriad Genetics).

Hereditary Cancer Test Identifies Deleterious Mutations in Endometrial Cancer

Two recent studies have shown that a Hereditary Cancer test can identify deleterious mutations in patients with endometrial cancer and additionally, showed the superior ability of the combined three biomarker test to predict survival in patients with platinum treated ovarian cancer.  More...
05 Apr 2016
Image: Immunochemistry of receptors for estrogen (ER), strong and diffuse nuclear staining in a tissue sample from a breast cancer patient (Photo courtesy of Steven Halls, MD).

Multigene Test Identifies Early Breast Cancer

The 21-gene Recurrence Score assay, nodal status, grade, and immunohistochemical markers are recommended for chemotherapy decision making in hormone receptor positive/ human epidermal growth factor receptor negative early breast cancer.  More...
30 Mar 2016
Image: The ABI 7900HT Fast Real-Time Polymerase Chain Reaction (PCR) System (Photo courtesy of Applied Biosystems).

Blood Test Gives Early Warning of Melanoma Relapse

Targeted immunotherapies have transformed melanoma care, extending median survival from around 9 to over 25 months but nevertheless, most patients still die of their disease and although most melanoma patients respond to treatment at first, their cancer can become resistant within a year.   More...
21 Mar 2016
Image:  Clostridium difficile colonies after 48 hours’ growth on blood agar plate. By competitive exclusion, healthy gut flora help limit growth of pathogenic yeasts and bacteria. Overgrowth of C. difficile in the gut can cause pseudomembranous colitis, and is the most frequently identified cause of antibiotic-associated diarrhea. (Image courtesy of Dr. Holdeman, Centers for Disease Control & Prevention (CDC; image ID #3647), and Wikimedia.)

Robust Method Developed for Microbiome Analysis

Scientists have developed a technique for genome sequence data analysis that enables to more efficiently and accurately identify differences between metagenomes for a variety of bacterial communities, which can help to study, diagnose, and treat many human diseases. In a new study, the method was successfully tested on intestinal microbiota.  More...
16 Mar 2016
Image: A cancer of the iris known as uveal melanoma (Photo courtesy of Dr. Jonathan Trobe, MD).

Biomarker Identifies Uveal Melanoma Patients at Risk for Metastasis

Uveal melanoma is a cancer of the eye involving the iris, ciliary body, or choroid, collectively referred to as the uvea. Tumors arise from the pigment cells that reside within the uvea giving color to the eye.   More...
15 Mar 2016
Image: Schematic diagram of the ultrasensitive solution-phase method for detecting antibodies, by agglutination-polymerase chain reaction (ADAP) (Photo courtesy of the University of California, Berkeley).

Ultrasensitive Antibody Detection Enabled by Agglutination-PCR

Antibodies are widely used biomarkers for the diagnosis of many diseases and assays based on solid-phase immobilization of antigens comprise the majority of clinical platforms for antibody detection, but can be undermined by antigen denaturation and epitope masking.   More...
14 Mar 2016
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Immunochromatographic Assay
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.