High-End Hematology Analyzers Compared for Overall Equipment Effectiveness
By LabMedica International staff writers Posted on 29 Apr 2022 |
![Image: The Yumizen H2500 hematology analyzer (Photo courtesy of Horiba) Image: The Yumizen H2500 hematology analyzer (Photo courtesy of Horiba)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2022-04-29/RLJ-294792600.jpg)
Although the performance of the automated hematology analyzers expressed as turn-around time is one of the important criteria in high-volume testing laboratories to deliver patient quality results on time, it may not be comparable for the analyzers from different companies.
In clinical laboratories with a heavy patient load, the testing quality of the automated hematology analyzers depends on their accuracy, reliability, and performance as well as efficiency. Continuous evaluation of the equipment with the appropriate methods is the key to ensure sustained quality of reporting in clinical laboratories.
Medical Laboratorians at the Christian Medical College (Vellore, India) and their colleagues evaluated and compared the overall equipment effectiveness (OEE), sensitivity, specificity, and efficiency of high-end hematology analyzers. A total of 400 anonymized left over’s K2 EDTA whole blood samples were analyzed for complete blood count (CBC). CBC analysis of all blood samples was performed using the different automated hematology analyzers.
The study was a was a prospective cross-sectional comparative study of four hematology analyzers: Yumizen H2500 (Horiba, Kyoto, Japan), the DxH 800 and DxH 900 (Beckman Coulter, Miami, FL, USA), and the XN-9000 (XN-10) (Sysmex Corporation, Kobe, Japan). The Yumizen H2500 uses the double hydrodynamic sequential system and the impedance method. Both DxH 800 and DxH 900 use impedance, and five light scatter and absorption measurements (volume, conductivity, and scatter [VCS] technology) method. This Sysmex XN-10 uses fluorescence and flow cytometry technology with a semiconductor laser to categorize WBCs. In case of additional fluorescence interference, it uses a recently developed a “parasitic red blood cell” (pRBC) flag to correct WBC counts on the WBC differential scattergram.
The investigators reported that the OEE was good and comparable for all the hematology analyzers except DxH 800 showing an average status. Confusion matrix highlights the difficulty for DxH 800 and DxH 900 to discriminate left shift or blasts with large hyper-segmented neutrophils. The flags triggered by Yumizen H2500 were markedly changed to large hyper-segmented neutrophils. Lymphoblast caused more misperception for XN-9000 (XN-10), as it came out to be atypical lymphocytes, or hypersegmented neutrophils. Although comparable in OEE index to other analyzers, the Yumizen H2500 seems to be more reliable in detecting the abnormal cells as it has high sensitivity, specificity and less turnaround time.
The authors concluded that all four hematology analyzers showed comparable OEE in technical evaluation. However, the Yumizen H2500 analyzer seems to be more reliable in detecting the abnormal cells as it has high sensitivity, specificity and less turnaround time compared to other analyzers. The study was published on April 26, 2022 in the journal Practical Laboratory Medicine.
Related Links:
Christian Medical College
Horiba
Beckman Coulter
Sysmex Corporation
Latest Hematology News
- Next Generation Instrument Screens for Hemoglobin Disorders in Newborns
- First 4-in-1 Nucleic Acid Test for Arbovirus Screening to Reduce Risk of Transfusion-Transmitted Infections
- POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy
- First Affordable and Rapid Test for Beta Thalassemia Demonstrates 99% Diagnostic Accuracy
- Handheld White Blood Cell Tracker to Enable Rapid Testing For Infections
- Smart Palm-size Optofluidic Hematology Analyzer Enables POCT of Patients’ Blood Cells
- Automated Hematology Platform Offers High Throughput Analytical Performance
- New Tool Analyzes Blood Platelets Faster, Easily and Accurately
- First Rapid-Result Hematology Analyzer Reports Measures of Infection and Severity at POC
- Bleeding Risk Diagnostic Test to Reduce Preventable Complications in Hospitals
- True POC Hematology Analyzer with Direct Capillary Sampling Enhances Ease-of-Use and Testing Throughput
- Point of Care CBC Analyzer with Direct Capillary Sampling Enhances Ease-of-Use and Testing Throughput
- Blood Test Could Predict Outcomes in Emergency Department and Hospital Admissions
- Novel Technology Diagnoses Immunothrombosis Using Breath Gas Analysis
- Advanced Hematology System Allows Labs to Process Up To 119 Complete Blood Count Results per Hour
- Unique AI-Based Approach Automates Clinical Analysis of Blood Data
Channels
Clinical Chemistry
view channel![Image: The new ADLM guidance will help healthcare professionals navigate respiratory virus testing in a post-COVID world (Photo courtesy of 123RF) Image: The new ADLM guidance will help healthcare professionals navigate respiratory virus testing in a post-COVID world (Photo courtesy of 123RF)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-05-27/98234491_m_normal_none.jpg)
New ADLM Guidance Provides Expert Recommendations on Clinical Testing For Respiratory Viral Infections
Respiratory tract infections, predominantly caused by viral pathogens, are a common reason for healthcare visits. Accurate and swift diagnosis of these infections is essential for optimal patient management.... Read more![Image: The 3D printed miniature ionizer is a key component of a mass spectrometer (Photo courtesy of MIT) Image: The 3D printed miniature ionizer is a key component of a mass spectrometer (Photo courtesy of MIT)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-04-10/MIT-Printed-Ion-01-press_0.jpg)
3D Printed Point-Of-Care Mass Spectrometer Outperforms State-Of-The-Art Models
Mass spectrometry is a precise technique for identifying the chemical components of a sample and has significant potential for monitoring chronic illness health states, such as measuring hormone levels... Read more![Image: Reaching speeds up to 6,000 RPM, this centrifuge forms the basis for a new type of inexpensive, POC biomedical test (Photo courtesy of Duke University) Image: Reaching speeds up to 6,000 RPM, this centrifuge forms the basis for a new type of inexpensive, POC biomedical test (Photo courtesy of Duke University)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-03-14/Spinning-Glowing (1).jpg)
POC Biomedical Test Spins Water Droplet Using Sound Waves for Cancer Detection
Exosomes, tiny cellular bioparticles carrying a specific set of proteins, lipids, and genetic materials, play a crucial role in cell communication and hold promise for non-invasive diagnostics.... Read more![Image: The new versatile assay has the ability to measure both total and bioavailable cortisol from serum (Photo courtesy of Aarhus University) Image: The new versatile assay has the ability to measure both total and bioavailable cortisol from serum (Photo courtesy of Aarhus University)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-03-04/ac3c04435_0004.jpg)
Highly Reliable Cell-Based Assay Enables Accurate Diagnosis of Endocrine Diseases
The conventional methods for measuring free cortisol, the body's stress hormone, from blood or saliva are quite demanding and require sample processing. The most common method, therefore, involves collecting... Read moreMolecular Diagnostics
view channel![Image: The new immune-based biomarker could pave the way for early detection HGOC (Photo courtesy of 123RF) Image: The new immune-based biomarker could pave the way for early detection HGOC (Photo courtesy of 123RF)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-06-18/176957304_m_normal_none_1.jpg)
Novel Immune-Based Biomarker Helps Detect Ovarian Cancer Years before Diagnosis
High-grade ovarian cancer (HGOC) ranks as the fifth-leading cause of cancer-related death among women. Over 90% of cases are diagnosed at advanced stages after the cancer has spread, posing significant... Read more![Image: The new blood test could prevent sudden child deaths caused by the rare heart condition (Photo courtesy of UCL) Image: The new blood test could prevent sudden child deaths caused by the rare heart condition (Photo courtesy of UCL)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-06-18/first_born_cropped_0.jpg)
New Blood Test Identifies Children with Rare Heart Condition
Hypertrophic cardiomyopathy (HCM) is a hereditary condition that leads to the thickening of the heart muscle and is the most frequent cause of sudden death among children and teenagers. There is no cure... Read more![Image: The new tests seek to detect mutant DNA in blood samples, indicating the presence of cancer cells (Photo courtesy of Christian Stolte/Weill Cornell) Image: The new tests seek to detect mutant DNA in blood samples, indicating the presence of cancer cells (Photo courtesy of Christian Stolte/Weill Cornell)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-06-17/landau_cfdna-cover-0-01.jpg)
Advanced Liquid Biopsy Technology Detects Cancer Earlier Than Conventional Methods
Liquid biopsy technology has yet to fully deliver on its significant potential. Traditional methods have focused on a narrow range of cancer-associated mutations that are often present in such low quantities... Read moreImmunology
view channel![Image: The AI tool predicts whether someone’s cancer will respond to immune checkpoint inhibitors (Photo courtesy of National Cancer Institute) Image: The AI tool predicts whether someone’s cancer will respond to immune checkpoint inhibitors (Photo courtesy of National Cancer Institute)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-06-05/Surgical oncology 43 (1).jpg)
AI Tool Predicts Cancer Patients’ Response to Immunotherapy
Immune checkpoint inhibitors are a form of immunotherapy drug that enables immune cells to target and destroy cancer cells. At present, the Food and Drug Administration has approved two predictive biomarkers... Read more![Image: Initially aimed at children with high-risk cancers, ZERO now includes all young cancer patients in Australia (Photo courtesy of Zero Childhood Cancer) Image: Initially aimed at children with high-risk cancers, ZERO now includes all young cancer patients in Australia (Photo courtesy of Zero Childhood Cancer)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-06-03/906uv0fs34hr.jpg)
Molecular Profiling Improves Diagnosis for Children with High Risk Cancers
Cancer remains the leading cause of disease-related death among children in most developed nations, and approximately one-fourth of these patients are diagnosed with aggressive, high-risk, or relapsed... Read moreMicrobiology
view channel![Image: The PA-100 AST System for rapid AMR detection has won the “Longitude Prize on AMR” (Photo courtesy of Sysmex Astrego) Image: The PA-100 AST System for rapid AMR detection has won the “Longitude Prize on AMR” (Photo courtesy of Sysmex Astrego)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-06-17/PA-100-diskette-device_1.jpg)
Rapid UTI Test Cuts Detection Time from 3 days to 45 Minutes
Antimicrobial Resistance (AMR), also known as antibiotic resistance or superbugs, is a silent but growing pandemic where bacteria have become resistant to lifesaving antibiotics due to decades of overuse and misuse.... Read more![Image: The POC PCR test shortens time for STI test results (Photo courtesy of Visby Medical) Image: The POC PCR test shortens time for STI test results (Photo courtesy of Visby Medical)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-06-05/device-front.jpg)
POC STI Test Shortens Time from ED Arrival to Test Results
In a 2024 sexually transmitted infections (STIs) surveillance report by the World Health Organization (WHO), over 2.5 million cases were recorded, alongside a rise in the inappropriate use of antibiotics... Read more![Image: The T-SPOT.TB test is now paired with the Auto-Pure 2400 liquid handling platform for accurate TB testing (Photo courtesy of Shutterstock) Image: The T-SPOT.TB test is now paired with the Auto-Pure 2400 liquid handling platform for accurate TB testing (Photo courtesy of Shutterstock)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-05-08/shutterstock_1065839396.jpg)
Integrated Solution Ushers New Era of Automated Tuberculosis Testing
Tuberculosis (TB) is responsible for 1.3 million deaths every year, positioning it as one of the top killers globally due to a single infectious agent. In 2022, around 10.6 million people were diagnosed... Read more![Image: The ASTar System has received US FDA 510(k) clearance (Photo courtesy of Q-linea AB) Image: The ASTar System has received US FDA 510(k) clearance (Photo courtesy of Q-linea AB)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-05-07/ASTar_ft-1-700x494.jpg)
Automated Sepsis Test System Enables Rapid Diagnosis for Patients with Severe Bloodstream Infections
Sepsis affects up to 50 million people globally each year, with bacteraemia, formerly known as blood poisoning, being a major cause. In the United States alone, approximately two million individuals are... Read morePathology
view channel![Image: The Hairpin Duplex Enhanced Fidelity Sequencing (HiDEF-seq) could reveal the causes of mutations (Photo courtesy of Shutterstock) Image: The Hairpin Duplex Enhanced Fidelity Sequencing (HiDEF-seq) could reveal the causes of mutations (Photo courtesy of Shutterstock)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-06-14/shutterstock_447424987.jpg)
New Technique Reveals Earliest Signs of Genetic Mutations
Mutations are alterations in the molecular "letters" that constitute the DNA code, which serves as the blueprint for all living cells. While some of these changes may be inconsequential, others can lead... Read more![Image: Diff-Quik stained smear from lung FNAB (Photo courtesy of Guoping Cai, Darin Dolezal, Ivana Kholová) Image: Diff-Quik stained smear from lung FNAB (Photo courtesy of Guoping Cai, Darin Dolezal, Ivana Kholová)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-06-13/Low-Res_jctp-23-68-g005.jpg)
New WHO Reporting System for Lung Cytopathology to Enhance Diagnostic Accuracy
Lung cancer continues to be the most common cause of cancer-related deaths worldwide and ranks as the second most frequently diagnosed cancer in both men and women. The role of lung cytopathology, which... Read more![Image: Three of 46 histomorphological phenotype clusters in small block tiles identified by AI from images of cancerous lung tissue (Photo courtesy of Dr. N. Coudray/NYU Grossman School of Medicine) Image: Three of 46 histomorphological phenotype clusters in small block tiles identified by AI from images of cancerous lung tissue (Photo courtesy of Dr. N. Coudray/NYU Grossman School of Medicine)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-06-12/inline_Untitled-3.jpg)
Self-Taught AI Tool Diagnoses and Predicts Severity of Common Lung Cancer
A computer program powered by artificial intelligence (AI) and trained on nearly half a million tissue images can effectively diagnose cases of adenocarcinoma, the most prevalent type of lung cancer.... Read more![Image: The new AI-powered statistics method has the potential to improve tissue and disease research (Photo courtesy of 123RF) Image: The new AI-powered statistics method has the potential to improve tissue and disease research (Photo courtesy of 123RF)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-06-11/17907939_m_normal_none_1.jpg)
Novel AI-Powered Method for Tissue Analysis Improves Understanding of Disease Pathology
Scientists at Brown University (Providence, RI, USA) and the University of Michigan (Ann Arbor, MI, USA) have created a groundbreaking computational technique to examine complex tissue data, potentially... Read moreTechnology
view channel![Image: Illustration of the microneedle patch (Photo courtesy of Karolinska Institutet) Image: Illustration of the microneedle patch (Photo courtesy of Karolinska Institutet)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-06-05/plaster_custom20240529112158.jpg)
Microneedle Patch Detects Skin Cancer Early
Wearable bioelectronics has emerged as a significant innovation in healthcare, especially in the field of biosensing, providing a new method to monitor individual health for both diagnostic and therapeutic purposes.... Read more![Image: The nanopore optofluidic chip used in the new diagnostic system (Photo courtesy of UC Santa Cruz) Image: The nanopore optofluidic chip used in the new diagnostic system (Photo courtesy of UC Santa Cruz)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-04-09/new-diagnostic-tool-ac.jpg)
New Diagnostic System Achieves PCR Testing Accuracy
While PCR tests are the gold standard of accuracy for virology testing, they come with limitations such as complexity, the need for skilled lab operators, and longer result times. They also require complex... Read moreIndustry
view channel![Image: For 46 years, Roche and Hitachi have collaborated to deliver innovative diagnostic solutions (Photo courtesy of Roche) Image: For 46 years, Roche and Hitachi have collaborated to deliver innovative diagnostic solutions (Photo courtesy of Roche)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-05-28/download.jpg)
Roche and Hitachi High-Tech Extend 46-Year Partnership for Breakthroughs in Diagnostic Testing
Roche (Basel, Switzerland) and Hitachi High-Tech (Tokyo, Japan) have renewed their collaboration agreement, committing to a further 10 years of partnership. This extension brings together their long-standing... Read more![Image: Scientists will evaluate new blood-based biomarkers using highly sensitive technology (Photo courtesy of 123RF) Image: Scientists will evaluate new blood-based biomarkers using highly sensitive technology (Photo courtesy of 123RF)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-05-13/103048801_m_normal_none.jpg)
Danaher and Johns Hopkins University Collaborate to Improve Neurological Diagnosis
Unlike severe traumatic brain injury (TBI), mild TBI often does not show clear correlations with abnormalities detected through head computed tomography (CT) scans. Consequently, there is a pressing need... Read more![Image: Beckman Coulter is now an authorized distributor of the MeMed Key immunoassay system and MeMed BV assay (Photo courtesy of Beckman Coulter) Image: Beckman Coulter is now an authorized distributor of the MeMed Key immunoassay system and MeMed BV assay (Photo courtesy of Beckman Coulter)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-05-09/PR_partnership_with_Beckman_Coulter_v1_2.jpg)
Beckman Coulter and MeMed Expand Host Immune Response Diagnostics Partnership
Beckman Coulter Diagnostics (Brea, CA, USA) and MeMed BV (Haifa, Israel) have expanded their host immune response diagnostics partnership. Beckman Coulter is now an authorized distributor of the MeMed... Read more![Image: Thermo Fisher will distribute Bio-Techne products across Europe (Photo courtesy of 123RF) Image: Thermo Fisher will distribute Bio-Techne products across Europe (Photo courtesy of 123RF)](https://globetechcdn.com/mobile_labmedica/images/stories/articles/article_images/2024-05-01/130140677_m_normal_none (1)_1.jpg)