Unique Diagnostic Test Based on Mass Spectrometry Technique Accurately Identifies Early-Stage Alzheimer's Disease
|
By LabMedica International staff writers Posted on 16 Mar 2022 |
|
Cerebral amyloid load is one of the first signs of early-onset Alzheimer's Disease (AD) in individuals with subjective memory complaints (SMCs) and has potential for use as a biomarker to indicate how the condition evolves. A new assay based on mass spectrometry has shown to be capable of quantifying amyloid-beta 40 and 42 proteins – both associated with the risk of having AD – in plasma samples.
Araclon Biotech (Zaragoza, Spain), a Grifols Group company, has developed ABtest-MS, a novel and unique method based on the mass spectrometry technique, that is capable of accurately quantifying amyloid 40 and 42 proteins in plasma samples. Diverse studies have confirmed the high predictive ability of the ABtest-MS assay to identify precisely those subjects with cerebral amyloid load, which would enable management of AD in its initial phases. ABtest-MS is a differentiating method that does not contain antibodies and whose process avoids enzymatic digestion, saving time and expense.
Data from the trial conducted on the FACEHBI cohort, obtained after two years of follow up, confirm the potential of the ABtest-MS to predict cerebral amyloid load in individuals with SMCs and the potential that the analysis of these markers have as an indicator of how the condition evolves. The data corresponding to five years of follow up with the cohort are currently being analyzed. In the second study, the multicenter A4 Study carried out in 50 centers, the ABtest-MS predicted the cerebral deposit of the amyloid protein (measured by PET) in plasma samples from 731 subjects. It also confirmed the suitability of utilizing a centralized and extensively validated method such as this assay in these broad and heterogenous studies. These data confirm other results previously obtained on more than 1,000 subjects in different AD stages from various international cohorts that have been recently featured in scientific publications.
"This test's predictive ability makes it ideal to detect early-stage Alzheimer's and accelerate the recruitment for clinical trials of new treatments, reducing the screening failure rate and associated costs," said Jose Terencio, Araclon CEO and Vice President of Innovation at Grifols.
Related Links:
Araclon Biotech
Latest Hematology News
- Next Gen CBC and Sepsis Diagnostic System Targets Faster, Earlier, Easier Results
- Newly Discovered Blood Group System to Help Identify and Treat Rare Patients
- Blood Platelet Score Detects Previously Unmeasured Risk of Heart Attack and Stroke
- Automated Benchtop System to Bring Blood Testing To Anyone, Anywhere
- New Hematology Analyzers Deliver Combined ESR and CBC/DIFF Results in 60 Seconds
- Next Generation Instrument Screens for Hemoglobin Disorders in Newborns
- First 4-in-1 Nucleic Acid Test for Arbovirus Screening to Reduce Risk of Transfusion-Transmitted Infections
- POC Finger-Prick Blood Test Determines Risk of Neutropenic Sepsis in Patients Undergoing Chemotherapy
- First Affordable and Rapid Test for Beta Thalassemia Demonstrates 99% Diagnostic Accuracy
- Handheld White Blood Cell Tracker to Enable Rapid Testing For Infections
- Smart Palm-size Optofluidic Hematology Analyzer Enables POCT of Patients’ Blood Cells
- Automated Hematology Platform Offers High Throughput Analytical Performance
- New Tool Analyzes Blood Platelets Faster, Easily and Accurately
- First Rapid-Result Hematology Analyzer Reports Measures of Infection and Severity at POC
- Bleeding Risk Diagnostic Test to Reduce Preventable Complications in Hospitals
- True POC Hematology Analyzer with Direct Capillary Sampling Enhances Ease-of-Use and Testing Throughput
Channels
Clinical Chemistry
view channel.jpg "Image: The new saliva-based test for heart failure measures two biomarkers in about 15 minutes (Photo courtesy of Trey Pittman)")
POC Saliva Testing Device Predicts Heart Failure in 15 Minutes
Heart failure is a serious condition where the heart muscle is unable to pump sufficient oxygen-rich blood throughout the body. It ranks as a major cause of death globally and is particularly fatal for... Read more
Screening Tool Detects Multiple Health Conditions from Single Blood Drop
Infrared spectroscopy, a method using infrared light to study the molecular composition of substances, has been a foundational tool in chemistry for decades, functioning similarly to a molecular fingerprinting... Read more
Integrated Chemistry and Immunoassay Analyzer with Extensive Assay Menu Offers Flexibility, Scalability and Data Commutability
As global healthcare systems increasingly shift towards networked laboratory operational models to enhance efficiency and patient access, there is a greater need for innovative solutions tailored to the... Read more
Molecular Diagnostics
view channel
Respiratory Panel to Help Clinicians Make Precise Treatment Decisions in Outpatient Settings
Respiratory tract infections are the primary reason for visits to emergency departments and subsequent hospitalizations. In the U.S., it is estimated that there are up to 41 million cases of influenza... Read more
Integrating Cardiovascular Risk Biomarkers Aids in Detection of ‘Inflammaging’
Cardiovascular diseases (CVD) continue to be the leading cause of death globally, responsible for nearly one-third of all fatalities worldwide. Traditionally, risk assessment for CVD has focused on well-established... Read more
Genetic Signature in Newborns Predicts Neonatal Sepsis Before Symptoms Appear
Neonatal sepsis, which occurs due to the body’s abnormal response to severe infection within the first 28 days of life, results in approximately 200,000 deaths globally each year. This condition affects around 1.... Read more.jpeg "Image: Researchers integrated multiple protein markers to predict health outcomes in individuals with chronic kidney disease (Photo courtesy of Adobe Stock)")
Integrating Multiple Protein Markers Predicts Health Outcomes in Chronic Kidney Disease Patients
Previous attempts to discover novel kidney biomarkers as risk factors for chronic kidney disease (CKD) progression have generally focused on evaluating proteins individually, which limits their prognostic... Read moreImmunology
view channel
Computational Tool Predicts Immunotherapy Outcomes for Metastatic Breast Cancer Patients
Immunotherapy aims to enhance the body’s immune response to target cancer cells, but not all patients experience a positive reaction to such treatments. Identifying which patients will benefit from immunotherapy... Read more
Biomarker Could Predict Immunotherapy Response in Liver Cancer
Until recently, patients diagnosed with hepatocellular carcinoma had limited treatment options, with existing therapies extending life by only a few months. Immunotherapy has emerged as a new alternative... Read more
Epigenetic Test Could Determine Efficacy of New Immunotherapy Treatments Against Multiple Myeloma
Multiple myeloma is a blood cancer that primarily affects individuals over the age of sixty, and its occurrence rises as the population ages. In this disease, the bone marrow—the spongy tissue inside bones... Read more
Microbiology
view channel
High-Accuracy Bedside Test to Diagnose Periprosthetic Joint Infection in Five Minutes
Periprosthetic joint infection (PJI) represents a significant global issue that is worsening as the number of joint replacements increases due to aging populations. In the United States alone, the anticipated... Read more_1.jpg "Image: Researchers have developed a method to quickly identify the most appropriate treatments for bacterial infections (Photo courtesy of Shutterstock)")
Innovative Diagnostic Approach for Bacterial Infections to Enable Faster and Effective Treatment
For patients with bacterial infections, timely treatment with the appropriate antibiotics significantly improves their chances of recovery. Current methods for identifying which antibiotics will be effective... Read more
Non-Invasive Stool Test to Diagnose Endometriosis and Help Reduce Disease Progression
Endometriosis, a painful condition impacting nearly 200 million women globally, occurs when tissue similar to the lining of the uterus grows outside its usual location, such as on the intestines or the... Read more
Automated Positive Blood Culture Sample Preparation Platform Designed to Fight Against Sepsis and AMR
Delayed administration of antibiotics to patients with bloodstream infections significantly increases the risk of morbidity and mortality. For optimal therapeutic outcomes, it is crucial to rapidly identify... Read morePathology
view channel
New Imaging Method Opens Door to Precision Diagnostics for Head and Neck Cancers
Head and neck cancers, while considered rare, represent a significant portion of cancer cases and have seen a notable increase over the past 30 years. These cancers encompass various malignant tumors that... Read more
Faster Measurement of Vibrational Fingerprint of Molecules to Advance Biomedical Diagnostics
Identifying different types of molecules and cells is a vital process in both basic and applied science. Raman spectroscopy serves as a widely utilized measurement technique for this purpose.... Read more
Technology
view channel
New Noninvasive Methods Detect Lead Exposure Faster, Easier and More Accurately at POC
Exposure to lead can negatively affect health in multiple ways, leading to damage in the brain and central nervous system, delays in development and growth, learning and behavioral issues, problems with... Read more
Noninvasive Test Detects Malaria Without Blood Sample
Malaria remains a significant global health issue, with approximately 250 million cases and over 600,000 deaths reported annually. Nearly half of the world's population is at risk for malaria infection,... Read more
Industry
view channel
Beckman Coulter Partners with BioPorto for Global Distribution of Acute Kidney Injury NGAL Tests
Acute kidney injury (AKI) is a sudden episode of kidney failure or damage that can occur within a few hours or days. This condition leads to the accumulation of waste products in the blood and disrupts... Read more_1.jpg "Image: CACLP 2025 will return on 21-24 March 2025 to attract professionals across the IVD industry (Photo courtesy of CACLP)")
CACLP 2025 New Date and Venue Announced
The 22nd China International In Vitro Diagnostic Expo, organized by the China Association of Clinical Laboratory Practice Expo (CACLP, Shanghai, China), is set to take place from March 21 to 24, 2025,... Read more
Roche to Develop New Diagnostic Technologies for Traumatic Brain Injuries
Traumatic brain injuries (TBI) represent a significant global health issue, affecting approximately 69 million people each year. TBI occurs when an external force disrupts normal brain function, with severity... Read more