适合中型实验室的细菌化验
|
By LabMedica International staff writers Posted on 07 Aug 2018 |
|
图片：iC-GPC革兰氏阳性测定是一种定性的多重检验，可直接检测阳性血液培养物中的五种最常见的革兰氏阳性菌，它们引起细菌性血流感染（图片蒙iCubate惠赐）。
细菌性脓毒症及相关并发症是病症的一大原因，也是美国的第十大死因。早期诊断并实施恰当的抗生素疗法对于病人的良好预后至关重要。
传统的培养法和抗生素敏感性试验方法是依赖于时间的过程，往往需要二至四天才能得到最终检验结果。最近开发的一款测定产品能准确可靠地检测五种最常见的革兰氏阳性菌，它们引起细菌性血流感染。
美国纽约州锡拉丘兹市的中纽约实验室联盟(www.laboratoryalliance.com)率领来自不同单位的一组医疗化验科学家，从2015年1月至2016年10月收集并检验了1,134名患者的血液培养临床样本。评估了三种不同的血液自动培养系统：美国北卡罗莱纳州杜勒姆市生物梅里埃股份有限公司(www.biomerieux-usa.com)的BacT/ALERT；美国马里兰州科基斯维尔市碧迪公司(www.bd.com)的BACTEC；美国马萨诸塞州沃尔瑟姆市赛默飞世尔科技公司(www.thermofisher.com)的VersaTREK。科学家们比较了上述产品与美国阿拉巴马州亨茨维尔市iCubate股份有限公司(www.icubate.com)的iC-GPC测定。
iC-GPC革兰氏阳性测定是一种定性的多重检验，可直接检测阳性血液培养物中引起细菌性血流感染的五种最常见的革兰氏阳性菌：金黄色葡萄球菌、表皮葡萄球菌、肺炎链球菌、粪肠球菌和屎肠球菌。通过多中心临床实验检验病人含革兰氏阳性球菌的血液培养物样本，该测定产品还检测到决定mecA、vanA和vanB耐药性的因素。
iC-GPC测定的总体百分比与美国德克萨斯州奥斯汀市Luminex公司(www.luminexcorp.com)的BC-GP测定一致，为95.5%。通过聚合酶链反应(PCR)和双向测序方法进一步分析不一致的样本。结果说明iC-GPC测定再加上iCubate系统能准确可靠地检测血流感染中五种最常见的革兰氏阳性菌及其耐药标志物。
该研究的论文首先发表于2018年6月13日的《临床微生物学杂志》(Journal of Clinical Microbiology)。作者总结说，iC-GPC测定提供了一种便宜得多的替代方案，尤其是对于中小规模医疗机构，实现血流感染常见革兰氏阳性菌及其耐药标志物的分子检测。
论文的领衔作者、微生物系主任Paul A. Granato博士说：“脓毒血症是引起血流感染的原因之一，传统的诊断或检测方法需要二至五天才能鉴定细菌，确定哪类抗生素最适合治疗患者。”
中纽约实验室联盟>>> www.laboratoryalliance.com
生物梅里埃>>> www.biomerieux-usa.com
碧迪公司>>> www.bd.com
赛默飞世尔科技公司>>> www.thermofisher.com
iCubate股份有限公司>>> www.icubate.com
Luminex公司 >>> www.luminexcorp.com
Gold Member
Respiratory Syncytial Virus Test
OSOM® RSV Test
Laboratory Software
ArtelWare
Gel Cards
DG Gel Cards
Latest 实验室技术 News
Channels
Clinical Chemistry
view channel
New PSA-Based Prognostic Model Improves Prostate Cancer Risk Assessment
Prostate cancer is the second-leading cause of cancer death among American men, and about one in eight will be diagnosed in their lifetime. Screening relies on blood levels of prostate-specific antigen... Read more
Extracellular Vesicles Linked to Heart Failure Risk in CKD Patients
Chronic kidney disease (CKD) affects more than 1 in 7 Americans and is strongly associated with cardiovascular complications, which account for more than half of deaths among people with CKD.... Read more
Molecular Diagnostics
view channel
Diagnostic Device Predicts Treatment Response for Brain Tumors Via Blood Test
Glioblastoma is one of the deadliest forms of brain cancer, largely because doctors have no reliable way to determine whether treatments are working in real time. Assessing therapeutic response currently... Read more
Blood Test Detects Early-Stage Cancers by Measuring Epigenetic Instability
Early-stage cancers are notoriously difficult to detect because molecular changes are subtle and often missed by existing screening tools. Many liquid biopsies rely on measuring absolute DNA methylation... Read more
“Lab-On-A-Disc” Device Paves Way for More Automated Liquid Biopsies
Extracellular vesicles (EVs) are tiny particles released by cells into the bloodstream that carry molecular information about a cell’s condition, including whether it is cancerous. However, EVs are highly... Read more
Blood Test Identifies Inflammatory Breast Cancer Patients at Increased Risk of Brain Metastasis
Brain metastasis is a frequent and devastating complication in patients with inflammatory breast cancer, an aggressive subtype with limited treatment options. Despite its high incidence, the biological... Read moreHematology
view channel
New Guidelines Aim to Improve AL Amyloidosis Diagnosis
Light chain (AL) amyloidosis is a rare, life-threatening bone marrow disorder in which abnormal amyloid proteins accumulate in organs. Approximately 3,260 people in the United States are diagnosed... Read more
Fast and Easy Test Could Revolutionize Blood Transfusions
Blood transfusions are a cornerstone of modern medicine, yet red blood cells can deteriorate quietly while sitting in cold storage for weeks. Although blood units have a fixed expiration date, cells from... Read more
Automated Hemostasis System Helps Labs of All Sizes Optimize Workflow
High-volume hemostasis sections must sustain rapid turnaround while managing reruns and reflex testing. Manual tube handling and preanalytical checks can strain staff time and increase opportunities for error.... Read more
High-Sensitivity Blood Test Improves Assessment of Clotting Risk in Heart Disease Patients
Blood clotting is essential for preventing bleeding, but even small imbalances can lead to serious conditions such as thrombosis or dangerous hemorrhage. In cardiovascular disease, clinicians often struggle... Read moreImmunology
view channel
Blood Test Identifies Lung Cancer Patients Who Can Benefit from Immunotherapy Drug
Small cell lung cancer (SCLC) is an aggressive disease with limited treatment options, and even newly approved immunotherapies do not benefit all patients. While immunotherapy can extend survival for some,... Read more
Whole-Genome Sequencing Approach Identifies Cancer Patients Benefitting From PARP-Inhibitor Treatment
Targeted cancer therapies such as PARP inhibitors can be highly effective, but only for patients whose tumors carry specific DNA repair defects. Identifying these patients accurately remains challenging,... Read more
Ultrasensitive Liquid Biopsy Demonstrates Efficacy in Predicting Immunotherapy Response
Immunotherapy has transformed cancer treatment, but only a small proportion of patients experience lasting benefit, with response rates often remaining between 10% and 20%. Clinicians currently lack reliable... Read more
Microbiology
view channel
Comprehensive Review Identifies Gut Microbiome Signatures Associated With Alzheimer’s Disease
Alzheimer’s disease affects approximately 6.7 million people in the United States and nearly 50 million worldwide, yet early cognitive decline remains difficult to characterize. Increasing evidence suggests... Read more
AI-Powered Platform Enables Rapid Detection of Drug-Resistant C. Auris Pathogens
Infections caused by the pathogenic yeast Candida auris pose a significant threat to hospitalized patients, particularly those with weakened immune systems or those who have invasive medical devices.... Read more
Pathology
view channel
Engineered Yeast Cells Enable Rapid Testing of Cancer Immunotherapy
Developing new cancer immunotherapies is a slow, costly, and high-risk process, particularly for CAR T cell treatments that must precisely recognize cancer-specific antigens. Small differences in tumor... Read more
First-Of-Its-Kind Test Identifies Autism Risk at Birth
Autism spectrum disorder is treatable, and extensive research shows that early intervention can significantly improve cognitive, social, and behavioral outcomes. Yet in the United States, the average age... Read more
Technology
view channel
Robotic Technology Unveiled for Automated Diagnostic Blood Draws
Routine diagnostic blood collection is a high‑volume task that can strain staffing and introduce human‑dependent variability, with downstream implications for sample quality and patient experience.... Read more
ADLM Launches First-of-Its-Kind Data Science Program for Laboratory Medicine Professionals
Clinical laboratories generate billions of test results each year, creating a treasure trove of data with the potential to support more personalized testing, improve operational efficiency, and enhance patient care.... Read more
Aptamer Biosensor Technology to Transform Virus Detection
Rapid and reliable virus detection is essential for controlling outbreaks, from seasonal influenza to global pandemics such as COVID-19. Conventional diagnostic methods, including cell culture, antigen... Read more
AI Models Could Predict Pre-Eclampsia and Anemia Earlier Using Routine Blood Tests
Pre-eclampsia and anemia are major contributors to maternal and child mortality worldwide, together accounting for more than half a million deaths each year and leaving millions with long-term health complications.... Read moreIndustry
view channel
New Collaboration Brings Automated Mass Spectrometry to Routine Laboratory Testing
Mass spectrometry is a powerful analytical technique that identifies and quantifies molecules based on their mass and electrical charge. Its high selectivity, sensitivity, and accuracy make it indispensable... Read more
AI-Powered Cervical Cancer Test Set for Major Rollout in Latin America
Noul Co., a Korean company specializing in AI-based blood and cancer diagnostics, announced it will supply its intelligence (AI)-based miLab CER cervical cancer diagnostic solution to Mexico under a multi‑year... Read more
Diasorin and Fisher Scientific Enter into US Distribution Agreement for Molecular POC Platform
Diasorin (Saluggia, Italy) has entered into an exclusive distribution agreement with Fisher Scientific, part of Thermo Fisher Scientific (Waltham, MA, USA), for the LIAISON NES molecular point-of-care... Read more