血清钙水平低增加SCA风险
|
By LabMedica International staff writers Posted on 06 Dec 2017 |
|
图片：研究显示血液中钙水平较低的人比钙水平高者更可能发生SCA（图片蒙SPL惠赐）。
90%以上患者的突发性心脏骤停(SCA)致命，死于SCA的男性有超过一半、女性近70%此前没有临床心脏病史。它是美国的主要死因之一，比任何一种癌症致死的人都多。
根据现行指导意见，许多SCA患者不算高风险者。这些冷峻的事实迫使人们寻找相对不贵的简单方法来发现SCA风险较高的人。血液中钙水平很容易监测，钙水平较低的人比钙水平高者更可能发生SCA。
一组科学家与美国加利福尼亚州洛杉矶市西达斯-西奈心脏研究所的科学家合作，在对267名SCA患者和445名对照者的日常护理过程中测量了血清中的钙水平。在所有SCA病例心脏骤停的90天前测量血清钙水平。根据每名患者的血清白蛋白水平校正总血清钙，估计一个与生理更相关的钙水平。如果病人的年龄是18岁或以上，且已知肌酐清除率(CrCl)和血清电解质水平，就纳入研究；通过分析肌酐清除率和血清电解质水平能够调节肾功能。
科学家发现，SCA患者中非裔美国人、糖尿病患者、慢性阻塞性肺病患者和慢性肾病患者的比例远远高于对照组。SCA患者血液透析的几率也高于对照组。此外，给SCA患者开的利尿剂也比β阻滞剂利用率相同的对照者多，尤其是髓袢利尿剂。血钙水平低于8.95毫克/分升与SCA几率比水平高于9.55毫克/分升时升高1.3倍有关（风险比2.33）。
该研究的论文发表于2017年9月21日的《梅奥临床学报》(Mayo Clinic Proceedings)杂志。领衔作者、西达斯-西奈心脏研究所博士后Hirad Yarmohammadi大夫说：“我们的研究显示，如果血清钙水平较低，即使在正常范围内，也会增加突发性心脏骤停的风险。虽然我们的成果这时还不能用于临床，但已向目标——通过更好地预测风险来改进病人护理——迈出了一大步。”
Related Links:
西达斯-西奈心脏研究所
根据现行指导意见，许多SCA患者不算高风险者。这些冷峻的事实迫使人们寻找相对不贵的简单方法来发现SCA风险较高的人。血液中钙水平很容易监测，钙水平较低的人比钙水平高者更可能发生SCA。
一组科学家与美国加利福尼亚州洛杉矶市西达斯-西奈心脏研究所的科学家合作，在对267名SCA患者和445名对照者的日常护理过程中测量了血清中的钙水平。在所有SCA病例心脏骤停的90天前测量血清钙水平。根据每名患者的血清白蛋白水平校正总血清钙，估计一个与生理更相关的钙水平。如果病人的年龄是18岁或以上，且已知肌酐清除率(CrCl)和血清电解质水平，就纳入研究；通过分析肌酐清除率和血清电解质水平能够调节肾功能。
科学家发现，SCA患者中非裔美国人、糖尿病患者、慢性阻塞性肺病患者和慢性肾病患者的比例远远高于对照组。SCA患者血液透析的几率也高于对照组。此外，给SCA患者开的利尿剂也比β阻滞剂利用率相同的对照者多，尤其是髓袢利尿剂。血钙水平低于8.95毫克/分升与SCA几率比水平高于9.55毫克/分升时升高1.3倍有关（风险比2.33）。
该研究的论文发表于2017年9月21日的《梅奥临床学报》(Mayo Clinic Proceedings)杂志。领衔作者、西达斯-西奈心脏研究所博士后Hirad Yarmohammadi大夫说：“我们的研究显示，如果血清钙水平较低，即使在正常范围内，也会增加突发性心脏骤停的风险。虽然我们的成果这时还不能用于临床，但已向目标——通过更好地预测风险来改进病人护理——迈出了一大步。”
Related Links:
西达斯-西奈心脏研究所
New
Gold Member
Clinical Drug Testing Panel
DOA Urine MultiPlex
Sperm Quality Analyis Kit
QwikCheck Beads Precision and Linearity Kit
6 Part Hematology Analyzer with RET + IPF
Mispa HX 88
Latest 临床化学 News
Channels
Clinical Chemistry
view channel
New PSA-Based Prognostic Model Improves Prostate Cancer Risk Assessment
Prostate cancer is the second-leading cause of cancer death among American men, and about one in eight will be diagnosed in their lifetime. Screening relies on blood levels of prostate-specific antigen... Read more
Extracellular Vesicles Linked to Heart Failure Risk in CKD Patients
Chronic kidney disease (CKD) affects more than 1 in 7 Americans and is strongly associated with cardiovascular complications, which account for more than half of deaths among people with CKD.... Read more
Molecular Diagnostics
view channel
Diagnostic Device Predicts Treatment Response for Brain Tumors Via Blood Test
Glioblastoma is one of the deadliest forms of brain cancer, largely because doctors have no reliable way to determine whether treatments are working in real time. Assessing therapeutic response currently... Read more
Blood Test Detects Early-Stage Cancers by Measuring Epigenetic Instability
Early-stage cancers are notoriously difficult to detect because molecular changes are subtle and often missed by existing screening tools. Many liquid biopsies rely on measuring absolute DNA methylation... Read more
“Lab-On-A-Disc” Device Paves Way for More Automated Liquid Biopsies
Extracellular vesicles (EVs) are tiny particles released by cells into the bloodstream that carry molecular information about a cell’s condition, including whether it is cancerous. However, EVs are highly... Read more
Blood Test Identifies Inflammatory Breast Cancer Patients at Increased Risk of Brain Metastasis
Brain metastasis is a frequent and devastating complication in patients with inflammatory breast cancer, an aggressive subtype with limited treatment options. Despite its high incidence, the biological... Read moreHematology
view channel
New Guidelines Aim to Improve AL Amyloidosis Diagnosis
Light chain (AL) amyloidosis is a rare, life-threatening bone marrow disorder in which abnormal amyloid proteins accumulate in organs. Approximately 3,260 people in the United States are diagnosed... Read more
Fast and Easy Test Could Revolutionize Blood Transfusions
Blood transfusions are a cornerstone of modern medicine, yet red blood cells can deteriorate quietly while sitting in cold storage for weeks. Although blood units have a fixed expiration date, cells from... Read more
Automated Hemostasis System Helps Labs of All Sizes Optimize Workflow
High-volume hemostasis sections must sustain rapid turnaround while managing reruns and reflex testing. Manual tube handling and preanalytical checks can strain staff time and increase opportunities for error.... Read more
High-Sensitivity Blood Test Improves Assessment of Clotting Risk in Heart Disease Patients
Blood clotting is essential for preventing bleeding, but even small imbalances can lead to serious conditions such as thrombosis or dangerous hemorrhage. In cardiovascular disease, clinicians often struggle... Read moreImmunology
view channel
Blood Test Identifies Lung Cancer Patients Who Can Benefit from Immunotherapy Drug
Small cell lung cancer (SCLC) is an aggressive disease with limited treatment options, and even newly approved immunotherapies do not benefit all patients. While immunotherapy can extend survival for some,... Read more
Whole-Genome Sequencing Approach Identifies Cancer Patients Benefitting From PARP-Inhibitor Treatment
Targeted cancer therapies such as PARP inhibitors can be highly effective, but only for patients whose tumors carry specific DNA repair defects. Identifying these patients accurately remains challenging,... Read more
Ultrasensitive Liquid Biopsy Demonstrates Efficacy in Predicting Immunotherapy Response
Immunotherapy has transformed cancer treatment, but only a small proportion of patients experience lasting benefit, with response rates often remaining between 10% and 20%. Clinicians currently lack reliable... Read more
Microbiology
view channel
Comprehensive Review Identifies Gut Microbiome Signatures Associated With Alzheimer’s Disease
Alzheimer’s disease affects approximately 6.7 million people in the United States and nearly 50 million worldwide, yet early cognitive decline remains difficult to characterize. Increasing evidence suggests... Read more
AI-Powered Platform Enables Rapid Detection of Drug-Resistant C. Auris Pathogens
Infections caused by the pathogenic yeast Candida auris pose a significant threat to hospitalized patients, particularly those with weakened immune systems or those who have invasive medical devices.... Read more
Pathology
view channel
Engineered Yeast Cells Enable Rapid Testing of Cancer Immunotherapy
Developing new cancer immunotherapies is a slow, costly, and high-risk process, particularly for CAR T cell treatments that must precisely recognize cancer-specific antigens. Small differences in tumor... Read more
First-Of-Its-Kind Test Identifies Autism Risk at Birth
Autism spectrum disorder is treatable, and extensive research shows that early intervention can significantly improve cognitive, social, and behavioral outcomes. Yet in the United States, the average age... Read more
Technology
view channel
Robotic Technology Unveiled for Automated Diagnostic Blood Draws
Routine diagnostic blood collection is a high‑volume task that can strain staffing and introduce human‑dependent variability, with downstream implications for sample quality and patient experience.... Read more
ADLM Launches First-of-Its-Kind Data Science Program for Laboratory Medicine Professionals
Clinical laboratories generate billions of test results each year, creating a treasure trove of data with the potential to support more personalized testing, improve operational efficiency, and enhance patient care.... Read more
Aptamer Biosensor Technology to Transform Virus Detection
Rapid and reliable virus detection is essential for controlling outbreaks, from seasonal influenza to global pandemics such as COVID-19. Conventional diagnostic methods, including cell culture, antigen... Read more
AI Models Could Predict Pre-Eclampsia and Anemia Earlier Using Routine Blood Tests
Pre-eclampsia and anemia are major contributors to maternal and child mortality worldwide, together accounting for more than half a million deaths each year and leaving millions with long-term health complications.... Read moreIndustry
view channel
New Collaboration Brings Automated Mass Spectrometry to Routine Laboratory Testing
Mass spectrometry is a powerful analytical technique that identifies and quantifies molecules based on their mass and electrical charge. Its high selectivity, sensitivity, and accuracy make it indispensable... Read more
AI-Powered Cervical Cancer Test Set for Major Rollout in Latin America
Noul Co., a Korean company specializing in AI-based blood and cancer diagnostics, announced it will supply its intelligence (AI)-based miLab CER cervical cancer diagnostic solution to Mexico under a multi‑year... Read more
Diasorin and Fisher Scientific Enter into US Distribution Agreement for Molecular POC Platform
Diasorin (Saluggia, Italy) has entered into an exclusive distribution agreement with Fisher Scientific, part of Thermo Fisher Scientific (Waltham, MA, USA), for the LIAISON NES molecular point-of-care... Read more