类风湿性关节炎检测预测患者对药物的反应
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By LabMedica International staff writers Posted on 15 Feb 2016 |
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图片：Vectra DA疾病活动度检测工具检测和评定12种与类风湿性关节炎（RA）相关的血清蛋白（照片由Crescendo Bioscience）。
一种检测类风湿性关节炎严重程度的诊断工具有助于指导患者选择生物性或非生物性药物，通过预测其对不同治疗药物和治疗策略的反应实现这一选择。
这种检测类风湿性关节炎疾病活动度的多种生物标记物血液检测工具将与类风湿性关节炎活动度相关的12种血清蛋白质的浓度合并为一个客观评分，评分在1-100分范围内，帮助医生做出信息含量更大的治疗决策。
Helsingborg Hospital（Sweden）的科研人员近期开展了一项研究，评价是否能将Vectra DA评分用于预测157名类风湿性关节炎患者的最佳二线治疗方案，这些患者对免疫抑制剂甲氨蝶呤（MTX）反应不完全。结果显示，对于MTX反应不完全的早期RA患者，Vectra DA检测能预测二线治疗药物三联疗法相对于抗TNF的相对疗效。Vectra DA评分大于44分时，指示疾病具有高度活动度。
Vectra DA由Crescendo Bioscience（South San Francisco，CA，SA）生产。另外两项研究显示，Vectra DA能指导医生终止治疗。其中一项研究发现，Vectra DA评分高和单一生物标志物检测结果为阳性的患者治疗后复发率为76%，相比之下Vectra DA评分低的患者治疗后复发率为32%。第三项研究发现，Vectra DA评分高与患者逐渐撤销治疗后疾病的复发相关。Vectra DA有助于辨别临床症状改善、但潜在的高疾病活动性水平的患者，这类患者容易复发或突发疾病。
Crescendo的首席医疗官，Elena Hitraya医学博士说明：“免疫抑制剂甲氨喋啶是类风湿性关节炎的一线治疗药物，但是，这种药物并非对所有患者都有效。鉴于此，医生需要为患者选择治疗方案。可以选择的治疗方案包括增加一种合成的生物药物，或增加一种生物药物，最常用的是抗肿瘤坏死因子（TNF）。”本研究在2015年11月7-11日，在旧金山（CA，USA）召开的美国风湿病学会/美国风湿病卫生专业人员协会(ACR/ARHP）会议上公布。
Related Links:
Helsingborg Hospital
Crescendo Bioscience
这种检测类风湿性关节炎疾病活动度的多种生物标记物血液检测工具将与类风湿性关节炎活动度相关的12种血清蛋白质的浓度合并为一个客观评分，评分在1-100分范围内，帮助医生做出信息含量更大的治疗决策。
Helsingborg Hospital（Sweden）的科研人员近期开展了一项研究，评价是否能将Vectra DA评分用于预测157名类风湿性关节炎患者的最佳二线治疗方案，这些患者对免疫抑制剂甲氨蝶呤（MTX）反应不完全。结果显示，对于MTX反应不完全的早期RA患者，Vectra DA检测能预测二线治疗药物三联疗法相对于抗TNF的相对疗效。Vectra DA评分大于44分时，指示疾病具有高度活动度。
Vectra DA由Crescendo Bioscience（South San Francisco，CA，SA）生产。另外两项研究显示，Vectra DA能指导医生终止治疗。其中一项研究发现，Vectra DA评分高和单一生物标志物检测结果为阳性的患者治疗后复发率为76%，相比之下Vectra DA评分低的患者治疗后复发率为32%。第三项研究发现，Vectra DA评分高与患者逐渐撤销治疗后疾病的复发相关。Vectra DA有助于辨别临床症状改善、但潜在的高疾病活动性水平的患者，这类患者容易复发或突发疾病。
Crescendo的首席医疗官，Elena Hitraya医学博士说明：“免疫抑制剂甲氨喋啶是类风湿性关节炎的一线治疗药物，但是，这种药物并非对所有患者都有效。鉴于此，医生需要为患者选择治疗方案。可以选择的治疗方案包括增加一种合成的生物药物，或增加一种生物药物，最常用的是抗肿瘤坏死因子（TNF）。”本研究在2015年11月7-11日，在旧金山（CA，USA）召开的美国风湿病学会/美国风湿病卫生专业人员协会(ACR/ARHP）会议上公布。
Related Links:
Helsingborg Hospital
Crescendo Bioscience
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