类风湿性关节炎检测预测患者对药物的反应
|
By LabMedica International staff writers Posted on 15 Feb 2016 |
|
图片：Vectra DA疾病活动度检测工具检测和评定12种与类风湿性关节炎（RA）相关的血清蛋白（照片由Crescendo Bioscience）。
一种检测类风湿性关节炎严重程度的诊断工具有助于指导患者选择生物性或非生物性药物，通过预测其对不同治疗药物和治疗策略的反应实现这一选择。
这种检测类风湿性关节炎疾病活动度的多种生物标记物血液检测工具将与类风湿性关节炎活动度相关的12种血清蛋白质的浓度合并为一个客观评分，评分在1-100分范围内，帮助医生做出信息含量更大的治疗决策。
Helsingborg Hospital（Sweden）的科研人员近期开展了一项研究，评价是否能将Vectra DA评分用于预测157名类风湿性关节炎患者的最佳二线治疗方案，这些患者对免疫抑制剂甲氨蝶呤（MTX）反应不完全。结果显示，对于MTX反应不完全的早期RA患者，Vectra DA检测能预测二线治疗药物三联疗法相对于抗TNF的相对疗效。Vectra DA评分大于44分时，指示疾病具有高度活动度。
Vectra DA由Crescendo Bioscience（South San Francisco，CA，SA）生产。另外两项研究显示，Vectra DA能指导医生终止治疗。其中一项研究发现，Vectra DA评分高和单一生物标志物检测结果为阳性的患者治疗后复发率为76%，相比之下Vectra DA评分低的患者治疗后复发率为32%。第三项研究发现，Vectra DA评分高与患者逐渐撤销治疗后疾病的复发相关。Vectra DA有助于辨别临床症状改善、但潜在的高疾病活动性水平的患者，这类患者容易复发或突发疾病。
Crescendo的首席医疗官，Elena Hitraya医学博士说明：“免疫抑制剂甲氨喋啶是类风湿性关节炎的一线治疗药物，但是，这种药物并非对所有患者都有效。鉴于此，医生需要为患者选择治疗方案。可以选择的治疗方案包括增加一种合成的生物药物，或增加一种生物药物，最常用的是抗肿瘤坏死因子（TNF）。”本研究在2015年11月7-11日，在旧金山（CA，USA）召开的美国风湿病学会/美国风湿病卫生专业人员协会(ACR/ARHP）会议上公布。
Related Links:
Helsingborg Hospital
Crescendo Bioscience
这种检测类风湿性关节炎疾病活动度的多种生物标记物血液检测工具将与类风湿性关节炎活动度相关的12种血清蛋白质的浓度合并为一个客观评分，评分在1-100分范围内，帮助医生做出信息含量更大的治疗决策。
Helsingborg Hospital（Sweden）的科研人员近期开展了一项研究，评价是否能将Vectra DA评分用于预测157名类风湿性关节炎患者的最佳二线治疗方案，这些患者对免疫抑制剂甲氨蝶呤（MTX）反应不完全。结果显示，对于MTX反应不完全的早期RA患者，Vectra DA检测能预测二线治疗药物三联疗法相对于抗TNF的相对疗效。Vectra DA评分大于44分时，指示疾病具有高度活动度。
Vectra DA由Crescendo Bioscience（South San Francisco，CA，SA）生产。另外两项研究显示，Vectra DA能指导医生终止治疗。其中一项研究发现，Vectra DA评分高和单一生物标志物检测结果为阳性的患者治疗后复发率为76%，相比之下Vectra DA评分低的患者治疗后复发率为32%。第三项研究发现，Vectra DA评分高与患者逐渐撤销治疗后疾病的复发相关。Vectra DA有助于辨别临床症状改善、但潜在的高疾病活动性水平的患者，这类患者容易复发或突发疾病。
Crescendo的首席医疗官，Elena Hitraya医学博士说明：“免疫抑制剂甲氨喋啶是类风湿性关节炎的一线治疗药物，但是，这种药物并非对所有患者都有效。鉴于此，医生需要为患者选择治疗方案。可以选择的治疗方案包括增加一种合成的生物药物，或增加一种生物药物，最常用的是抗肿瘤坏死因子（TNF）。”本研究在2015年11月7-11日，在旧金山（CA，USA）召开的美国风湿病学会/美国风湿病卫生专业人员协会(ACR/ARHP）会议上公布。
Related Links:
Helsingborg Hospital
Crescendo Bioscience
Gold Member
Antipsychotic TDM Assays
Saladax Antipsychotic Assays
New
Alpha-Fetoprotein Reagent
AFP Reagent Kit
New
Blood Gas and Chemistry Analysis System
Edan i500
Latest 临床化学 News
Channels
Clinical Chemistry
view channel
AI-Powered Blood Test Accurately Detects Ovarian Cancer
Ovarian cancer ranks as the fifth leading cause of cancer-related deaths in women, largely due to late-stage diagnoses. Although over 90% of women exhibit symptoms in Stage I, only 20% are diagnosed in... Read more
Automated Decentralized cfDNA NGS Assay Identifies Alterations in Advanced Solid Tumors
Current circulating cell-free DNA (cfDNA) assays are typically centralized, requiring specialized handling and transportation of samples. Introducing a flexible, decentralized sequencing system at the... Read more
Mass Spectrometry Detects Bacteria Without Time-Consuming Isolation and Multiplication
Speed and accuracy are essential when diagnosing diseases. Traditionally, diagnosing bacterial infections involves the labor-intensive process of isolating pathogens and cultivating bacterial cultures,... Read more
First Comprehensive Syphilis Test to Definitively Diagnose Active Infection In 10 Minutes
In the United States, syphilis cases have surged by nearly 80% from 2018 to 2023, with 209,253 cases recorded in the most recent year of data. Syphilis, which can be transmitted sexually or from mother... Read moreMolecular Diagnostics
view channel
POC Oral Swab Test to Increase Chances of Pregnancy in IVF
Approximately 15% of couples of reproductive age experience involuntary childlessness. A significant reason for this is the growing trend of delaying family planning, a global shift that is expected to... Read more
Microbial Cell-Free DNA Test Accurately Identifies Pathogens Causing Pneumonia and Other Lung Infections
Bronchoalveolar lavage (BAL) is a commonly used procedure for diagnosing lung infections, especially in immunocompromised patients. However, standard tests often fail to pinpoint the exact pathogen, leading... Read more
Hematology
view channel
First Point-of-Care Heparin Monitoring Test Provides Results in Under 15 Minutes
Heparin dosing requires careful management to avoid both bleeding and clotting complications. In high-risk situations like extracorporeal membrane oxygenation (ECMO), mortality rates can reach about 50%,... Read more
New Scoring System Predicts Risk of Developing Cancer from Common Blood Disorder
Clonal cytopenia of undetermined significance (CCUS) is a blood disorder commonly found in older adults, characterized by mutations in blood cells and a low blood count, but without any obvious cause or... Read more
Immunology
view channel
Stem Cell Test Predicts Treatment Outcome for Patients with Platinum-Resistant Ovarian Cancer
Epithelial ovarian cancer frequently responds to chemotherapy initially, but eventually, the tumor develops resistance to the therapy, leading to regrowth. This resistance is partially due to the activation... Read more
Machine Learning-Enabled Blood Test Predicts Immunotherapy Response in Lymphoma Patients
Chimeric antigen receptor (CAR) T-cell therapy has emerged as one of the most promising recent developments in the treatment of blood cancers. However, over half of non-Hodgkin lymphoma (NHL) patients... Read more
Microbiology
view channel
New Blood Test Detects Up to Five Infectious Diseases at POC
Researchers have developed a prototype flow-through assay capable of detecting up to five different infections, with results that can be quickly analyzed and transmitted via a specialized smartphone app.... Read more
Molecular Stool Test Shows Potential for Diagnosing TB in Adults with HIV
Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, led to 1.25 million deaths in 2023, with 13% of those occurring in people living with HIV. The current primary diagnostic method for... Read more
Pathology
view channel
Groundbreaking Chest Pain Triage Algorithm to Transform Cardiac Care
Cardiovascular disease is responsible for a third of all deaths worldwide, and chest pain is the second most common reason for emergency department (ED) visits. With EDs often being some of the busiest... Read more
AI-Based Liquid Biopsy Approach to Revolutionize Brain Cancer Detection
Detecting brain cancers remains extremely challenging, with many patients only receiving a diagnosis at later stages after symptoms like headaches, seizures, or cognitive issues appear. Late-stage diagnoses... Read more
Technology
view channel
Advanced Predictive Algorithms Identify Patients Having Undiagnosed Cancer
Two newly developed advanced predictive algorithms leverage a person’s health conditions and basic blood test results to accurately predict the likelihood of having an undiagnosed cancer, including ch... Read more
Light Signature Algorithm to Enable Faster and More Precise Medical Diagnoses
Every material or molecule interacts with light in a unique way, creating a distinct pattern, much like a fingerprint. Optical spectroscopy, which involves shining a laser on a material and observing how... Read more
Disposable Microchip Technology Could Selectively Detect HIV in Whole Blood Samples
As of the end of 2023, approximately 40 million people globally were living with HIV, and around 630,000 individuals died from AIDS-related illnesses that same year. Despite a substantial decline in deaths... Read more
Pain-On-A-Chip Microfluidic Device Determines Types of Chronic Pain from Blood Samples
Chronic pain is a widespread condition that remains difficult to manage, and existing clinical methods for its treatment rely largely on self-reporting, which can be subjective and especially problematic... Read moreIndustry
view channel
Qiagen Acquires NGS Analysis Software Company Genoox
QIAGEN (Venlo, the Netherlands) has signed a definitive agreement to acquire Genoox (Tel Aviv, Israel), a provider of artificial intelligence (AI)-powered software that enables clinical labs to scale and... Read more
Cepheid and Oxford Nanopore Technologies Partner on Advancing Automated Sequencing-Based Solutions
Cepheid (Sunnyvale, CA, USA), a leading molecular diagnostics company, and Oxford Nanopore Technologies (Oxford, UK), the company behind a new generation of sequencing-based molecular analysis technologies,... Read more
Grifols and Tecan’s IBL Collaborate on Advanced Biomarker Panels
Grifols (Barcelona, Spain), one of the world’s leading producers of plasma-derived medicines and innovative diagnostic solutions, is expanding its offer in clinical diagnostics through a strategic partnership... Read more