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Pathology

Image: A histopathology of hepatocellular carcinoma: a mononuclear inflammatory cell infiltrate extends from portal areas and disrupts the limiting plate of hepatocytes which are undergoing apoptosis, the so-called interface hepatitis of chronic active hepatitis. In this case, the hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (HBcAb) were positive (Photo courtesy of University of Utah Medical School).

Virus-Associated Liver Cancer Detected by Blood Tests

Viral infection with either hepatitis C virus (HCV) or Hepatitis B virus (HBV) is the chief cause of liver cancer in the world today, accounting for 80% of hepatocellular carcinoma (HCC). The viruses cause HCC because massive inflammation, fibrosis and eventual cirrhosis occurs within the liver. More...
27 Mar 2019
Image: The Quo-Test HbA1c Analyzer: People with diabetes who undergo joint replacement surgery are at sharply higher risk of experiencing elevated blood sugar after the operation (Photo courtesy of EKF Diagnostics).

Diabetics Experience High Blood Sugar after Joint Surgery

People with diabetes who undergo joint replacement surgery are at sharply higher risk of experiencing elevated blood sugar after the operation, increasing their chances of developing infections and other complications. More...
26 Mar 2019
Image: The Q Exactive hybrid mass spectrometer (Photo courtesy of Thermo Fisher Scientific).

Proteomics Profile Early Detection Ovarian Cancer

High-grade ovarian cancer (HGOC) is the leading cause of mortality from gynecological malignancies, due to diagnosis at a metastatic stage. Current screening options fail to improve mortality due to the absence of early-stage-specific biomarkers. More...
26 Mar 2019
Image: The ZymoBIOMICS DNA Mini Kit is designed for purifying DNA from any sample input that is immediately ready for microbiome or metagenome analyses (Photo courtesy of Zymo Research).

Oral Bacteria Linked to More Aggressive Tumors

Pancreatic cystic neoplasms (PCN) are increasingly detected in the general population. They comprise a clinically challenging entity with potential to progress to invasive cancer. The disease is often discovered late, which means that in most cases the prognosis is poor. More...
26 Mar 2019
Image: A histopathology of clear cell papillary renal cell carcinoma (Photo courtesy of Nephron).

Five-Gene Signature Predicts Survival from Renal Cell Carcinoma

Papillary renal cell carcinomas include type 1 lesions, which are characterized by small cells in single layers and scanty cytoplasm and type 2 lesions, which are distinguished by larger cells, pseudo-stratified nuclei, and voluminous eosinophilic cytoplasm. More...
20 Mar 2019
Image: The TruSight Tumor 15 uses next-generation sequencing (NGS) technology to provide a comprehensive assessment of 15 genes that are commonly mutated in solid tumors (Photo courtesy of Illumina).

EBUS More Reliable Than Histology for Cancer Diagnoses

Radial probe endobronchial ultrasound (EBUS) is a minimally invasive procedure that improves localization of peripheral pulmonary lesions. Cytology samples of the suspect lesion site collected by radial EBUS bronchoscopy provides good diagnostic sensitivity estimated at 73%, whereas histology does not definitely diagnose malignancy in approximately 20% cases. More...
20 Mar 2019
Image: The three-dimensional (3D) herringbone nanopatterned microfluidic chip that detects cancer faster (Photo courtesy of the University of Kansas).

Nanopatterned Microfluidic Chip Detects Cancer Markers

The performance of current microfluidic methods for exosome detection is constrained by boundary conditions, as well as fundamental limits to microscale mass transfer and interfacial exosome binding. More...
13 Mar 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.