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Pathology

Image: The Q Exactive hybrid mass spectrometer (Photo courtesy of Thermo Fisher Scientific).

Proteomics Profile Early Detection Ovarian Cancer

High-grade ovarian cancer (HGOC) is the leading cause of mortality from gynecological malignancies, due to diagnosis at a metastatic stage. Current screening options fail to improve mortality due to the absence of early-stage-specific biomarkers. More...
26 Mar 2019
Image: The ZymoBIOMICS DNA Mini Kit is designed for purifying DNA from any sample input that is immediately ready for microbiome or metagenome analyses (Photo courtesy of Zymo Research).

Oral Bacteria Linked to More Aggressive Tumors

Pancreatic cystic neoplasms (PCN) are increasingly detected in the general population. They comprise a clinically challenging entity with potential to progress to invasive cancer. The disease is often discovered late, which means that in most cases the prognosis is poor. More...
26 Mar 2019
Image: A histopathology of clear cell papillary renal cell carcinoma (Photo courtesy of Nephron).

Five-Gene Signature Predicts Survival from Renal Cell Carcinoma

Papillary renal cell carcinomas include type 1 lesions, which are characterized by small cells in single layers and scanty cytoplasm and type 2 lesions, which are distinguished by larger cells, pseudo-stratified nuclei, and voluminous eosinophilic cytoplasm. More...
20 Mar 2019
Image: The TruSight Tumor 15 uses next-generation sequencing (NGS) technology to provide a comprehensive assessment of 15 genes that are commonly mutated in solid tumors (Photo courtesy of Illumina).

EBUS More Reliable Than Histology for Cancer Diagnoses

Radial probe endobronchial ultrasound (EBUS) is a minimally invasive procedure that improves localization of peripheral pulmonary lesions. Cytology samples of the suspect lesion site collected by radial EBUS bronchoscopy provides good diagnostic sensitivity estimated at 73%, whereas histology does not definitely diagnose malignancy in approximately 20% cases. More...
20 Mar 2019
Image: The three-dimensional (3D) herringbone nanopatterned microfluidic chip that detects cancer faster (Photo courtesy of the University of Kansas).

Nanopatterned Microfluidic Chip Detects Cancer Markers

The performance of current microfluidic methods for exosome detection is constrained by boundary conditions, as well as fundamental limits to microscale mass transfer and interfacial exosome binding. More...
13 Mar 2019
Image: The Guardant360 kit for biopsy-free tissue sequencing for cancer (Photo courtesy of Guardant Health).

Liquid Biopsy Proves Effective as Biopsy for NSCLC

Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). NSCLC accounts for about 85% of all lung cancers. As a class, NSCLCs are relatively insensitive to chemotherapy, compared to small cell carcinoma. More...
13 Mar 2019
Image: A diagram shows how the microfluidics device separates cancer cells from blood. The green circles represent cancer cells (Photo courtesy of Professor Ian Papautsky, PhD).

New Microfluidics Device Detects Cancer Cells in Blood

The ability to successfully isolate cancer cells is a crucial step in enabling liquid biopsy where cancer could be detected through a simple blood draw. This would eliminate the discomfort and cost of tissue biopsies, which use needles or surgical procedures as part of cancer diagnosis. More...
12 Mar 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.