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Pathology

Image: Early research found that a genetic test could lead to a reduction in painful procedures and minimize the over-treatment of people at low risk for anal cancer (Photo courtesy of Queen Mary University of London).

Genetic Test Identifies Risk of Anal Cancer

Anal cancer is mostly caused by human papillomavirus (HPV), which is the same virus that causes cervical cancer. Diagnosis presents many challenges as full biopsies are painful, and taking a small sample of cells for cytology is problematic because lesions can be hidden. More...
14 Jun 2017

Immune System Changes Signal Early Brain Cancer

Glioma is a heterogeneous primary malignant brain tumor with a median survival time, for the most common adult subtype, glioblastoma, of only 14 months. Changes in immune activity appear to signal a growing brain tumor five years before symptoms arise. More...
14 Jun 2017
Image: A new study suggests using a new genomic-dequencing approach could help develop an assay that could detect cancer at early stages (Photo courtesy of Memorial Sloan Kettering Cancer Center).

Sequencing Approach to Detect Genomic Alterations

An early study evaluated a sophisticated new genomic-sequencing approach that analyzes cell-free DNA (cfDNA) in the blood of people with advanced cancer and will help development of a future assay that could potentially detect cancer in its earliest stages. More...
13 Jun 2017
Image: A histopathology of Wilms tumor: the epithelial tubular structures may show mucinous differentiation as indicated. Ciliated epithelium and squamous metaplasia may also be seen (Photo courtesy of Pathpedia).

Genetic Mutation Identified for Childhood Kidney Cancer

The underlying mechanism that causes aneuploidy might be important in understanding cancer risk and not solely having the wrong number of chromosomes in a cell. It is an important development that provides valuable information about the fundamental biology of cancer. More...
13 Jun 2017

Elevated Blood Platelet Count Predicts Cancer

The most common route to cancer diagnosis follows the development of symptoms, and definitive diagnosis by biopsy and access to specialist care often rely on a primary care physician to recognize the possibility of cancer. More...
08 Jun 2017

Intestinal Fungi Contribute to Alcoholic Liver Disease

Chronic liver disease with cirrhosis is the 12th leading cause of death in the USA, and alcoholic liver disease accounts for approximately half of all cirrhosis deaths. Chronic alcohol consumption is associated with intestinal bacterial dysbiosis, yet little is known about the contribution of intestinal fungi, or mycobiota, to alcoholic liver disease. More...
08 Jun 2017
Image: Immunohistochemistry (IHC) staining of human epidermal growth factor receptor 2 (HER2) in biopsy specimens showing intratumoral homogeneity and heterogeneity (Photo courtesy of Fudan University).

Heterogeneity Influences Cancer Immunohistochemistry Results

Many gastric cancer (GC) patients are with inoperable lesions and endoscopic biopsy becomes the only available approach to obtain tumor tissues for human epidermal growth factor receptor 2 (HER2) assessment. Unlike resected specimens, biopsy specimens are influenced by many factors and in turn more difficult to manipulate. More...
06 Jun 2017
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.