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Pathology

Gout Increases Risk of Advanced Chronic Kidney Disease

Chronic kidney disease (CKD) is a major public health epidemic, with at least 1 in 10 individuals having some degree of kidney impairment, contributing substantially to adverse clinical and economic outcomes. More...
11 Sep 2019
Image: A major new study on the association between blood glucose levels, including HbA1c, and risks of organ impairment in people with type 1 diabetes can make a vital contribution to diabetes care (Photo courtesy of HealthEngine).

Blood Sugar Levels Affect Risks in Type 1 Diabetes

Type 1 diabetes is the predominant form of diabetes diagnosed in childhood and is characterized by increased blood glucose levels resulting from insulin deficiency. More...
11 Sep 2019
Image: A diagram illustrating the combined use of bioorthogonal ligation (i.e., the reaction between Tz and TCO) and disulfide cleavage–driven by DTT to enable capture and release of CTCs using Click Chips (Photo courtesy of University of California, Los Angeles).

CTC Purification Enables Identification of Cancer-Linked Genetic Arrangements

The use of circulating tumor cells (CTCs) as a surrogate tumor source for molecular profiling of disease offers a potential noninvasive diagnostic solution for understanding underlying tumor biology, guiding treatment interventions, and monitoring disease progression. More...
29 Aug 2019
Image: A photomicrograph showing numerous completely sclerotic glomeruli and severe chronic tubulointerstitial nephritis from a patient with end-stage kidney disease (Photo courtesy of Dr. Jian-Hua Qiao, MD, FCAP).

Proteinuria Contributes to Greater CKD Progression Risk in Men

Older men with chronic kidney disease had a 50% increased risk for progression to end-stage kidney disease (ESKD) compared with women and this may be the result of higher levels of proteinuria. More...
29 Aug 2019
Image: A new study showed men with diabetes had a higher blood testosterone level than non-diabetic men (Photo courtesy of Diamed Diagnostical Center).

Hormone Levels of Diabetic Men Not Related to Prostate Cancer Risk

Diabetes mellitus (DM) is a group of metabolic disorders characterized by high blood sugar levels over a prolonged period and is conventionally associated with an increased risk of cancer; however, inverse associations of diabetes with prostate cancer are well described. More...
21 Aug 2019
Image: A circulating tumor cell (arrow) diagnosed by the isolation by size of epithelial tumor cells (ISET) test (The pores of the filter are also visible) (Photo courtesy of Chichiselector).

Circulating Tumor Cells Directly Detected in Blood Samples

Tumor cells circulating in blood are markers for the early detection and prognosis of cancer. However, detection of these cells is challenging because of their scarcity. More...
21 Aug 2019
Image: The NextSeq 500 next-generation sequencer (Photo courtesy of Illumina).

Combination of Gene Mutations Linked to Endometrial Cancer

The endometrium is the dynamic inner layer of the uterus, composed of stroma and epithelial cells that undergo monthly proliferation, differentiation, and shedding throughout the menstrual cycle in reproductive age women. More...
21 Aug 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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