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Pathology

Image: Blood tests can sample circulating DNA cast off by solid tumors, providing information about the tumor and its likely response to treatment without the need for an invasive tumor biopsy (Photo courtesy of Rachel June Wong).

Post-Treatment Colon Cancer Recurrence Identified by ctDNA Detection

By analyzing circulating tumor DNA (ctDNA) samples after treatment, it may be possible to identify stage III colon cancer patients who are at increased risk of relapse and disease progression. More...
30 Oct 2019
Image: A microscope image of thyroid cancer cells, specifically papillary thyroid carcinoma, or PTC (Photo courtesy of Wendong Yu/Baylor College of Medicine).

Metabolic Classification of Thyroid Nodules Uses MS Imaging

Fine-needle aspiration (FNA) biopsy is a well-established technique for diagnosis of suspicious thyroid lesions. However, histologic discrimination between malignant and benign thyroid nodules from FNA can be challenging. More...
26 Oct 2019
Image: The histological detection of chlamydia in human testicular biopsies (Photo courtesy of Queensland University of Technology).

Chlamydia in Testicular Tissue Linked to Male Infertility

Infectious diseases, such as mumps virus infection of the human testis, are known to play a role in spermatogenic dysfunction and have been associated with abnormal sperm parameters. More...
26 Oct 2019
Image: A and B, Mucinous adenocarcinoma of colon and indeterminate PMS2 immunohistochemistry staining. C and D, Poorly differentiated carcinoma of colon and indeterminate MLH1 staining. E and F, Endometrial carcinoma and focal MSH6 staining (Photo courtesy of University of Texas Southwestern Medical Center).

Lynch Syndrome Screening by IHC Leads to Mutation Studies

Lynch syndrome or hereditary nonpolyposis colorectal cancer is an autosomal dominant genetic condition that is associated with a high risk of colon cancer, as well as other cancers including endometrial cancer, ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin. More...
24 Oct 2019
Image: The PATHFAST compact benchtop automatic immunoassay analyzer (Photo courtesy of LSI Medience).

Presepsin Concentrations Correlate with Kidney Function Decline

Sepsis is an important public health problem with more than 750,000 patients reported yearly in the USA with similar figures in Europe. Sepsis continues to be a challenge for practitioners, as sepsis mortality rates are still high despite new antimicrobial and resuscitation agents. More...
24 Oct 2019
Image: A histopathology of meningeal carcinomatosis with infiltration of the brain gray matter and perivascular malignant cells (Photo courtesy of Zuzana Gdovinova.

Methylation Signature Identified for Brain Metastases of Lung Cancer

When lung cancer metastasizes to the brain, it means the primary lung cancer has created a secondary cancer in the brain. About 20% to 40% of adults with non-small cell lung cancer go on to develop brain metastases at some point during their illness. More...
17 Oct 2019
Image: A histopathology of high-grade invasive ductal carcinoma of the breast (not otherwise specified, grade 3). This is an example of a triple-negative breast cancer, basal-like carcinoma (Photo courtesy of Lee Moffitt Cancer Center).

Triple-Negative Breast Cancer Classified from Whole-Genome Sequencing

A diagnosis of triple negative breast cancer means that the three most common types of receptors known to fuel most breast cancer growth–estrogen, progesterone and the HER-2/neu gene are not present in the cancer tumor. More...
16 Oct 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.