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Pathology

Image: Histological sections of a moderately well differentiated squamous cell carcinoma of the lung showing infiltrating sheets and tongues of malignant squamous cells with whorls of keratin (Photo courtesy of Department of Health Western Australia).

Liquid Biopsy Lung Cancer Screening Method Developed

Genomic blood tests for cancer screening and early detection have become the focus of attention in the molecular diagnostic space, though most activity so far has been either toward pan-cancer screening tools, or in a few other specific tumor types like colorectal cancer, where tests hope to vie against colonoscopy and existing stool-based methods. More...
09 Apr 2020
Image: Photomicrograph of a vaginal epithelial clue cell coated with Gardnerella vaginalis (Photo courtesy of Universidad Autónoma de Zacatecas).

Potential Microbial Markers Identified for Cervical Pre-Cancer Progression

Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections. However, only a small percentage of high-risk (HR) HPV infections progress to cervical pre-cancer and cancer. The role of the cervicovaginal microbiome (CVM) in the natural history of HR-HPV has been investigated. More...
08 Apr 2020
Image: The cobas Epidermal Growth Factor Receptor (EGFR) gene Mutation Test v2 (Photo courtesy of Roche).

Early Prediction of Resistance to Tyrosine Kinase Inhibitors Reported

 Epidermal growth factor receptor (EGFR) gene mutations that confer sensitivity to tyrosine kinase inhibitors (TKI) in non-small cell lung carcinomas paved the way for a precision medicine approach in this neoplastic form. More...
31 Mar 2020
Image: Schematic diagram of a urine score for noninvasive accurate diagnosis and prediction of kidney transplant rejection study (Photo courtesy of the University of California, San Francisco).

Urine-Based Kidney Transplantation Rejection Risk Assay Launched

 For kidney transplant recipients, prompt and accurate detection of transplant rejection is vital for timely intervention. Unfortunately, the gold standard for diagnosis of rejection is kidney biopsy, an invasive procedure. More...
30 Mar 2020
Image: Histopathology of cancerous breast tissue, the tumor cells have proliferated in a close pattern without tubular formation. This tumor represented moderately differentiated ductal carcinoma (Photo courtesy of The Japanese Society of Pathology).

Genetic Testing Benefits Postmenopausal Women with Breast Cancer

 Germline genetic testing for pathogenic variants (PVs) in cancer susceptibility genes after breast cancer diagnosis may inform cancer treatment, prevention, and testing of relatives. Postmenopausal women with breast cancer had a threefold higher prevalence of pathogenic variants in breast cancer-associated genes than their cancer-free counterparts. More...
26 Mar 2020
Image: Multitarget Stool DNA Screening has a high positive predictive value for colorectal neoplasia regardless of exposure to previous colonoscopy (Photo courtesy of Madeline Morr).

Multitarget Stool DNA Predicts Colorectal Neoplasia

 Most colorectal cancers are due to old age and lifestyle factors, with only a small number of cases due to underlying genetic disorders. Screening is effective for preventing and decreasing deaths from colorectal cancer. More...
25 Mar 2020
Image: Circulating tumor DNA (ctDNA) assays can be used for the sensitive detection of minimal residual disease in patients treated for early-stage breast cancer (Photo courtesy of Natera).

Liquid Biopsy Assays Target Mutations and Improves Recurrence Prediction

 The concept of creating bespoke or personalized mutation panels to use for cancer recurrence detection and residual disease monitoring is not new at this point. Scientists began piloting these methods several years ago, initially tracking single mutations and then collections of alterations derived from tumor sequencing data. More...
25 Mar 2020
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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