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Pathology

Image: A lunchbox-sized device for nucleic acid quantification that can be powered by sunlight, a flame or electricity enables the diagnosis of disease in settings with unreliable power supply (Photo courtesy of Cornell University).

Cancer Detection Device Proves Effective in Field Testing

A decentralized approach to diagnostics can decrease the time to treatment of infectious diseases in resource-limited settings, yet most modern diagnostic tools require stable electricity and are not portable. More...
01 Oct 2018
Image: Auramine O stained Mycobacterium leprae in FFPE tissue section under ×40 objective of light-emitting diode fluorescence microscope A: Sample with high BI; B. Sample with low BI (Photo courtesy of Armauer Hansen Research Institute).

Molecular and Classical Methods Compared for Leprosy Diagnosis

Mycobacterium leprae is the causative agent of leprosy, a chronic granulomatous infectious disease affecting the skin and peripheral nerves. Leprosy manifests in various forms based on the immunological profiles and bacterial load in patients. More...
27 Sep 2018
Image: The AmplideX PCR/CE C9orf72 assay kit (Photo courtesy of Asuragen).

Dementia Assay Gets Favorable Evaluation

An assay to detect the most common genetic mutation associated with amyotropic lateral sclerosis (ALS) and frontotemporal dementia (FTD) has been shown to have significant advantages over a laboratory-developed test in an evaluation. More...
27 Sep 2018
Image: An ELISA Kit for Kidney Injury Molecule 1 (Kim1) (Photo courtesy of Enzo Life Sciences).

Blood Test May Help Detect Kidney Cancer Earlier

Renal cell carcinoma (RCC) has the potential for cure with surgery when diagnosed at an early stage. Kidney injury molecule-1 (KIM-1) has been shown to be elevated in the plasma of RCC patients. More...
26 Sep 2018
Image: The Aperio Scanscope XT slide scanner (Photo courtesy of University of New South Wales).

Nano-LCMS Differentiates Liver Diseases

Non-alcoholic steatohepatitis (NASH) is among the leading causes of liver disease worldwide. It is increasingly recognized that the phenotype of NASH may involve a number of different pathways, of which each could become important therapeutic targets. More...
24 Sep 2018
Image: The Oncotype DX analyzes 21 genes in the tumor to estimate a woman\'s risk of the cancer coming back after surgery (Photo courtesy of Genomic Health).

Biomarker Tests Benefit Certain Cancer Patients

The benefit of biomarker tests has been reinvestigated to support the decision for or against adjuvant systemic chemotherapy in certain breast cancer patients, that is, women with primary hormone receptor-positive, HER2/neu-negative breast cancer and 0 to 3 affected lymph nodes. More...
17 Sep 2018
Image: The Archer FusionPlex Sarcoma Kit: A targeted sequencing assay to simultaneously detect and identify fusions of 26 genes associated with soft tissue cancers (Photo courtesy of Illumina).

Targeted Sequencing Approach for Sarcoma Gene Fusions Validated

Sarcomas are rare cancers that grow in a patient's connective tissue, such as bones, muscles, tendons, nerves, and fat. Symptoms may not be apparent, since the only signs of sarcomas are lumps on a person's skin. More...
12 Sep 2018
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.