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Pathology

Image: (A and B) Photomicrographs of the layers of the device; (C) the mold ready for casting and (D) the chip mounted on a slide (Photo courtesy of San Diego State University).

Microfluidic Device Isolates Circulating Tumor Cell Clusters

The three main challenges of cancer treatment are metastases, recurrence, and acquired therapy resistance. These challenges have been closely linked to circulating cancer cell clusters. More...
03 Jul 2019
Image: iPLEX Gold is a SNP genotyping assay that runs on Sequenom\'s MassArray mass spectrometer (Photo courtesy of Sequenom).

New Genetic Link to Premenopausal Breast Cancer Discovered

Breast cancer is the most common cancer in women, with an estimated one out of every eight women expected to develop it in their lifetimes. While environmental factors like smoking, diet or lack of physical activity can lead to cancer, a person's genes also contribute to the risk of getting the disease. More...
03 Jul 2019
Image: The BioMark HD real-time polymerase chain reaction (PCR) platform (Photo courtesy of Fluidigm).

New Biomarker Test Improves Diagnosis of Ovarian Cancer

Ovarian cancer is often discovered at a late stage and has a high mortality rate. Overall 5-year survival is only 30% to 40% after treatment, and there has been no test specific enough to justify screening. More...
02 Jul 2019
Image: A color hereditary cancer risk screening kit (Photo courtesy of Color Genomics).

Pathogenic Variant Carriers Missed by Current Genetic Testing

Current guidelines recommend genetic testing for people who have a personal or family history of cancer that indicates they might be at an increased risk of harboring a pathogenic familial variant, but this approach could miss people who lack any personal or family history. More...
27 Jun 2019
Image: Identifying a metastatic colorectal cancer patient’s Consensus Molecular Subtype (CMS) could help oncologists determine the most effective course of treatment (Photo courtesy of University of Southern California).

Identifying Colorectal Cancer Subtypes Improves Treatment Decisions

Colorectal cancer is the second leading cause of cancer death in the USA, and is expected to cause about 51,000 deaths in 2019, but until now, it was unclear which drugs were most effective for which patients. More...
25 Jun 2019
The handheld MasSpec Pen device which can be connected to a Mass Spectrometer for diagnosing ovarian and other cancers (Photo courtesy of the University of Texas at Austin).

Masspec Pen Evaluated for Rapid Diagnosis of Cancer

 Ovarian cancer is a highly lethal disease and the fifth leading cause of all cancer-related deaths in women. Accurate diagnosis and stratification of ovarian cancer is important to develop personalized treatment approaches. More...
20 Jun 2019
A histopathology of pancreatic ductal adenocarcinoma, a gland-forming cancer. In this example, the adenocarcinoma has wrapped around a nerve (center of the image) (Photo courtesy of JHM).

Novel Methylated DNA Markers Assay Detects Cancer

 An estimated 56,770 people will be diagnosed with pancreatic cancer in the U.S. in 2019, and more than 45,750 will die from the disease. Pancreatic cancer is the third leading cause of cancer-related deaths in the U.S. and is expected to become the second leading cause by 2020. More...
20 Jun 2019
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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