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Pathology

Image: Nanoanalysis of plasma volatile organic compounds used novel DNA-decorated carbon nanotube vapor sensors to noninvasively distinguish ovarian and pancreatic cancer from benign and control samples (Photo courtesy of the University of Pennsylvania)

Electronic Nose Sensor Accurately Detects Ovarian, Pancreatic Cancers

Ovarian cancer is a cancer that forms in or on an ovary. It results in abnormal cells that have the ability to invade or spread to other parts of the body. When this process begins, there may be no or only vague symptoms. Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a mass. More...
15 Jul 2021
Image: The Super Sensitive 1-STEP Polymer HRP IHC detection kit (Photo courtesy of BioGenix)

Protein Biomarker Helps Diagnose Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC), characterized by dense desmoplastic stroma laid down by pancreatic stellate cells (PSC), has no reliable diagnostic biomarkers for timely detection. More...
14 Jul 2021
Image: Histology of acute pancreatitis. Microscopically, the fat necrosis consists of steatocytes (adipocytes) that have lost their nuclei and whose cytoplasm has a granular pink appearance as seen on the right. Some hemorrhage is seen at the left in this case of acute pancreatitis (Photo courtesy of Texas A&M University)

Biomarkers Diagnose and Predict Acute Pancreatitis

Acute pancreatitis (AP) is an inflammatory reaction caused by the activated pancreatic enzymes in the pancreas, which leads to subsequent pancreatic autodigestion, edema, hemorrhage, necrosis, and even distal organ dysfunction. More...
08 Jul 2021
Image: The Bioanalyzer RNA 6000 Nano assay provides reliable and reproducible characterization of total RNA and mRNA from multiple sample types, from as low as 5 ng of total RNA (Photo courtesy of Agilent)

Respiratory Syncytial Virus Bronchiolitis Has Different Subtypes

Bronchiolitis is the leading cause of hospitalization in infants in the USA, accounting for about 110,000 hospitalizations annually. In addition to the substantial acute morbidity, around 30% of infants hospitalized for bronchiolitis (“severe bronchiolitis”) subsequently develop asthma in childhood. More...
30 Jun 2021
Image: A blood test for glucose may reveal hyperglycemia which has been evaluated as a risk factor in pancreatic cancer (Photo courtesy of Amit Akirov, MD)

Hyperglycemia Evaluated as a Risk Factor in Pancreatic Cancer

Pancreatic ductal adenocarcinoma (pancreatic cancer) has a five-year survival rate of 9%. Most patients are diagnosed with metastatic disease due to late presenting symptoms and only 10% to 20% are able to undergo surgery with a curative intent. More...
23 Jun 2021
Image: Genetic variants are associated with unexplained sudden cardiac death in both adult White and African American individuals (Photo courtesy of Latin American Society of Interventional Cardiology)

Genetic Variants Associated with Unexplained Sudden Cardiac Death

As many as 450,000 Americans die every year from a sudden, fatal heart condition, and in slightly more than one in ten cases the cause remains unexplained even after an autopsy. Most sudden cardiac deaths are caused by abnormal heart rhythms called arrhythmias and the most common life-threatening arrhythmia is ventricular fibrillation. More...
22 Jun 2021
Image: Schematics of how the Signatera bespoke mPCR NGS assay works (Photo courtesy of Natera)

CtDNA Analysis Assesses Early Relapse Detection in Colorectal Cancer

Colorectal cancer (CRC) is a type of cancer that begins in the large intestine (colon). The colon is the final part of the digestive tract. Colon cancer typically affects older adults, though it can happen at any age. It usually begins as small, noncancerous (benign) clumps of cells called polyps that form on the inside of the colon. Over time some of these polyps can become colon cancers. More...
17 Jun 2021
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.