Pathology
Developed Immunoassay Predicts Benefits of Anti-PD-1 Therapy in NSCLC
Lung cancer is the most common cause of cancer-related deaths worldwide. However, current targeted therapies and immunotherapies have gradually improved patient survival. Anti-programmed cell death-1 (PD-1) antibodies (Abs) are key drugs in non-small-cell lung cancer treatment; however, clinical benefits with anti-PD-1 monotherapy are limited. More...12 May 2021
Holographic Histopathology Enables Fast, Precise Diagnostics
Microscopic assessment of biopsied and resected tissues is central to understanding the underlying pathophysiology and clinical states of many patients. Because most microscopic specimens are translucent to visible light, conventional histological methods achieve image contrast using exogenous labels. More...10 May 2021
Genetic Background and Clinicopathologic Features Established for Adult-Onset Nephronophthisis
Nephronophthisis (NPH) is a genetic disorder of the kidneys which mainly affects children. It is classified as a medullary cystic kidney disease. The disorder is inherited in an autosomal recessive fashion and, although rare, is the most common genetic cause of childhood kidney failure. More...06 May 2021
African-American MS Patients Experience More Rapid B-Cell Repopulation
Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system). In MS, the immune system attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between the brain and the rest of the body. More...06 May 2021
GPS Assay Associated with Long-Term Prostate Cancer Outcomes
Long-term cancer outcomes are an important consideration when deciding between active surveillance (AS) and immediate treatment for newly diagnosed prostate cancer. Multiple prospective AS studies that predominantly include patients at the lowest risk of progression have demonstrated a low risk of distant metastasis (DM) and prostate cancer–specific mortality (PCSM) with extended follow-up. More...03 May 2021
New Genetic Factors Involved in Sudden Unexpected Death in Children
About 10% of deaths in infants and children occur suddenly and have no apparent cause. Sudden Unexpected Death in Pediatrics (SUDP) encompasses several related phenomena, including Sudden Infant Death Syndrome (SIDS), Sudden Unexplained Death in Childhood (SUDC), and Sudden Unexpected Infant Death (SUID). More...29 Apr 2021
Altered Perivascular Fibroblast Activity Precedes ALS Disease Onset
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the motor neurons that eventually causes muscular atrophy, paralysis and death. There is currently no cure. The cause of ALS is only understood in the 5% to 10% of patients who have an inherited form of the disease. More...28 Apr 2021
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In Other News
RNA-Sequencing Predicts Immunotherapy Success in Bladder Cancer
Tissue Counterpart to Monoclonal B-Cell Lymphocytosis Characterized
Breast Cancer Histopathology Employs Infrared Spectroscopic Imaging
Coagulation Dysfunction and Infection Evaluated in Patients with AECOPD
Spatial Landscape of Lung Pathology Investigated During COVID-19 Progression
Leukocyte Epigenomics and Artificial Intelligence Predict Late-Onset Alzheimer’s Disease
Single-Cell Transcriptomic Analysis Traces Neuroblastomas to Developing Adrenal Neuroblasts
Whole-Genome Sequencing Aids Rare Disease Diagnosis
Calcitonin and Procalcitonin Immunoassays Investigated for Medullary Thyroid Carcinoma
Immune Cells in Cerebrospinal Fluid Predict Response to Immunotherapy
Pediatric Pancreatic Cancer Diagnosed From cfDNA Fragments in Urine
CSF Biomarker Flags Parkinson's Pathology Much Earlier
Five Genes Help Predict Lewy Body Dementia
Clinical Germline Testing Evaluated for Pediatric Cancer Patients
Genetic Risk of Inflammatory Bowel Disease Appears Distinct in African Americans
ctDNA Provides Prognostic Clues in Advanced BRAF-Mutated Melanoma Cases
22-Gene Genomic Classifier Validated in Recurrent Prostate Cancer Patients
Blood Biomarker Predicts Dementia in Cerebral Small Vessel Disease
Proteogenomic And Metabolomic Studies Characterize Human Glioblastoma
Exome Sequencing Identified Pathogenic Variants in Cerebral Palsy Patients
Biomarkers Evaluate Kidney Injury in Cancer Patients
Biomarker Predicts Pancreatic Cancer Patients’ Response to CD40 Immunotherapy
TAP1 Gene Polymorphisms Associated with Recurrent Respiratory Papillomatosis
The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.