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Microbiology

Image: Photomicrograph of a buffy coat smear of the patient’s blood collected on the third hospital day. Anaplasma phagocytophilum inclusions are seen in the cytoplasm of two different granulocyte stages (a metamyelocyte and a myelocyte). Arrows indicate morulae (Photo courtesy of Westchester Medical Center).

Tick-Borne Diseases Diagnosed with Multiplex Molecular Panel

Tick-borne diseases, which afflict humans and other animals, are caused by infectious agents transmitted by tick bites. Tick-borne illnesses are caused by infection with a variety of pathogens, including rickettsia and other types of bacteria, viruses, and protozoa. More...
26 Dec 2018
Image: A simplified diagram of the Hepatitis C (HCV) replication cycle (Photo courtesy of Graham Malcolm Beards, DSc).

HCV-RNA Present in Body Fluids in High Viral Load Patients

Hepatitis C virus (HCV) causes both acute and chronic infection. Acute HCV infection is usually asymptomatic, and is only very rarely (if ever) associated with life-threatening disease. About 15%–45% of infected persons spontaneously clear the virus within six months of infection without any treatment. More...
26 Dec 2018
Image: The Simoa HD-1 Analyzer is a fully automated instrument for running immunoassays (Photo courtesy of Quanterix).

Urinary Biomarkers for Tuberculosis Explored

The gold standard for tuberculosis (TB) diagnosis is the isolation in culture of Mycobacterium tuberculosis in biological samples. However, culture is time consuming and does not accomplish the need of quickly and properly starting treatment, it is not always feasible in extra-pulmonary TB and it is difficult to carry out in resource-limited settings. More...
25 Dec 2018
Image: Visual detection of RT-LAMP assay. The tubes represent BAV strains and the negative controls used in the visual inspection. 1-7, BAV strains; 8-13, other viruses; 14, negative control (Photo courtesy of Wuhan Institute of Virology).

Banna Virus Detected by Reverse Transcription-Loop-Mediated Isothermal Amplification

Banna virus (BAV) has been isolated from a diverse group of vertebrates and invertebrates, including mosquitos, ticks, midges, cattle, and pigs from different regions in China, Vietnam, and Indonesia. BAV is considered to be an emerging pathogen that can result in human infections with possible manifestation of fever and viral encephalitis. More...
25 Dec 2018
Image: Digitally colorized scanning electron microscopic (SEM) image depicts numerous filamentous Ebola virus particles (red) budding from a chronically infected VERO E6 cell (blue). New technology can distinguish Ebola infected patients from other endemic febrile diseases (Photo courtesy of National Institute of Allergy and Infectious Diseases).

POC Diagnostic Differentiates Ebola from Endemic Febrile Diseases

Hemorrhagic fever outbreaks such as Ebola are difficult to detect and control because of the lack of low-cost, easily deployable diagnostics and because initial clinical symptoms mimic other endemic diseases such as malaria. More...
24 Dec 2018
Image: A histopathology of cytomegalovirus infection in the lung showing typical owl-eye inclusions; FDA clears new CMV test for newborns (Photo courtesy of Danny Wiedbrauk, PhD).

Newborn Cytomegalovirus Test Cleared for Marketing

Cytomegalovirus or CMV is a common virus that infects people of all ages. In the USA, nearly one in three children are already infected with CMV by age five and over half of adults by age 40 have been infected with CMV. More...
20 Dec 2018
Image: The SD BIOLINE Malaria Ag P.f/Pan test is a rapid, qualitative and differential test for the detection of histidine-rich protein II (HRP-II) antigen of Plasmodium falciparum and common Plasmodium lactate dehydrogenase (pLDH) of Plasmodium species in human whole blood (Photo courtesy of Alere).

Rapid Malaria Diagnostic Test Detects Placental Infection

Malaria remains one of the most important parasitic infections in humans. It is endemic throughout the tropical and subtropical regions of the world and is responsible for more than 200 million clinical cases and more than 400,000 deaths each year. More...
19 Dec 2018
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