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Hematology

Image: The CellTiter-Glo 3D cell viability assay (Photo courtesy of Promega).

Potential Screening for Tailoring Treatment of AML

Acute Myeloid Leukemia (AML) is a serious disorder of certain blood-forming cells. In this disease, certain early precursor cells in the bone marrow that usually develop into white blood cells do not mature properly. They remain frozen as primitive cells called blasts, unable to further differentiate and mature. More...
17 Dec 2018
Image: Tumor heterogeneity, clonal evolution and therapy resistance was revealed using single cell profiling of multiple myeloma patients (Photo courtesy of Weizmann Institute of Science).

Unique Genetic Makeup of Myeloma Tumor Cells Profiled

Multiple myeloma is the second-most common type of blood cancer. Multiple myeloma occurs when plasma cells in the bone marrow, the cells that produce antibodies, proliferate out of control and lead to various type of organ failure and death. More...
17 Dec 2018
Image: The CareStart HRP2 rapid diagnostic test for Plasmodium falciparum malaria (Photo courtesy of Access Bio).

Plasmodium vivax Isolated in Duffy Negative Individuals

Malaria in Nigeria is principally due to Plasmodium falciparum and, to a lesser extent to P. malariae and P. ovale. P. vivax is thought to be absent in Nigeria in particular and sub-Saharan Africa in general, due to the near fixation of the Duffy negative gene in this population. More...
12 Dec 2018
Image: Major trauma victims who receive transfusions of packed blood 22 days old or older may face increased risk of death within 24 hours (Photo courtesy of South West London Pathology).

Transfusions with Older Blood Linked to Adverse Events

After a serious injury, the leading cause of death is loss of blood. Major trauma victims who receive transfusions of packed blood 22 days old or older may face increased risk of death within 24 hours. More...
11 Dec 2018
Image: A bone marrow smear of a patient with Acute Myeloid Leukemia; dysplastic changes are noted in both the granulocytic and erythroid lineages (Photo courtesy of Peter Maslak).

Acute Myeloid Leukemia Regulatory Networks Identified

Adult acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes abnormal myeloblasts (a type of white blood cell), red blood cells, or platelets. AML is a heterogeneous disease caused by a variety of alterations in transcription factors, epigenetic regulators and signaling molecules. More...
28 Nov 2018
Image: The ABX Pentra 60 C+ automated hematological analyzer (Photo courtesy of Horiba).

Malaria Parasitaemia Correlated with Monocyte to Lymphocyte Ratio

In spite of a declining trend in the number of cases and deaths over the last few years, malaria still causes significant mortality and morbidity and the bulk of the burden is observed in children under five years of age. More...
28 Nov 2018
Image: A photomicrograph of sickle cells in human blood: both normal red blood cells and sickle-shaped cells are present (Photo courtesy of Dr. Graham Beards).

Rapid Test for Sickle-Cell Disease Evaluated

Sickle cell disease (SCD) is a common, life‐threatening genetic disorder that is best managed when diagnosed early by newborn screening. Sickle cell disease (SCD) is highly prevalent in sub-Saharan Africa and central India. Sickle cell anemia is the most common and severe form of SCD. More...
15 Nov 2018
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.