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Hematology

Image: The FACSCalibur flow cytometer used to immunophenotype pediatric leukemia (Photo courtesy of Becton Dickinson).

Peripheral Blood Flow Cytometry Classifies Pediatric Acute Leukemia

Historically, flow cytometry performed on the bone marrow aspirate (BMFC) has been the standard for the immunophenotypic characterization of acute leukemia. Recent data have demonstrated the high sensitivity and specificity of peripheral blood flow cytometry for the diagnosis of pediatric leukemia. More...
25 Feb 2019
Image: A diagram of how leukemia NOX2 derived superoxide is a driver of pro-tumoral p16INK4a-dependent senescence in bone marrow stromal cells (Photo courtesy of University of East Anglia).

Leukemia Prematurely Ages Bone Marrow Cells

Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells. More...
20 Feb 2019
Image: A representative photomicrograph of bronchial lavage (BL) cytospin of obstructive airway disease participants Subsets of neutrophils characterized as per number of lobes in their nucleus (Photo courtesy of University of Newcastle).

Hypersegmented Neutrophils Associated with Reduced Lung Function

Neutrophils are phagocytic innate immune cells, which patrol the blood vessels and become activated in response to inflammatory triggers. Activation results in neutrophil migration to the site of infection, where pathogens can be eliminated by phagocytosis or NETosis. More...
19 Feb 2019
Image: The MAGPIX single or multiplex automated immunoassay reader (Photo courtesy of Bio-Rad).

Assays Detect Inherited Blood Disorders Associated with Malaria

Plasmodium parasites have co-evolved with human hosts and exert a considerable evolutionary pressure on mutations that confer a degree of protection against malaria. More...
07 Feb 2019
Image: An XN automated hematology analyzer that can also be used for malaria diagnosis (Photo courtesy of Sysmex).

Automated Malaria Diagnosis Evaluated Using Autoanalyzer

Early and accurate diagnosis of malaria is a critical aspect of efforts to control the disease, and several diagnostic tools are available. Microscopic assessment of a peripheral blood smear enables direct visualization of parasites in infected red blood cells and is the clinical diagnostic gold standard. More...
04 Feb 2019
Image: Bone marrow biopsy from a patient with polycythemia vera showing a hypercellular marrow as a result of an increase of myeloid, erythroid and megakaryocytic elements (Photo courtesy of Karl Theil MD).

Tumor Sequencing Finds Mutations Caused by Blood Disorder

Clinical sequencing assays aim to identify somatic mutations in cancer cells for accurate diagnosis and treatment. However, most clinical-grade implementations lack patient-matched germline DNA, and supplemental analyses are needed to infer the mutational status of variants. More...
15 Jan 2019
Image: A peripheral blood film from a patient with plasma cell leukemia showing four plasma cells and rouleaux formation of erythrocytes (Photo courtesy of the Tsuyako Saito).

New Definition for Plasma Cell Leukemia Proposed

Plasma cell leukemia (PCL) is an uncommon but aggressive malignancy that accounts for 1% to 2% of all plasma cell dyscrasias. PCL has been defined as the presence of ≥ 20% circulating plasma cells (CPCs) on conventional white blood cell differential count and an absolute plasma cell count of ≥ 2 × 109/L in the peripheral blood. More...
09 Jan 2019
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.