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Hematology

Image: The BK virus (BKV) is a ubiquitous human polyomavirus that causes hemorrhagic cystitis in hematopoietic stem cell transplantation patients and nephropathy in kidney transplantation recipients. Poorly cohesive urothelial cells possess amorphous and smudgy nuclei, indicative of BK viral infection (Photo courtesy of Pathos223).

Stem Cell Transplantation Increases Risk of Infection-Related Mortality

Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative therapeutic modality for various malignant and nonmalignant hematological conditions. The best results of allogeneic HSCT were obtained when the stem cells from a human leukocyte antigen (HLA)-matched sibling were used, such a donor can only be found for approximately 30% of patients. More...
29 May 2019
Image: The SpectraMax 340 PC 384 Microplate Reader (Photo courtesy of Molecular Devices).

Enzyme May Indicate Predisposition to Cardiovascular Disease

Redox-related plasma proteins are candidate reporters of protein signatures associated with endothelial structure/function. Thiol-proteins from protein disulfide isomerase (PDI) family are unexplored in this context. More...
28 May 2019
Image: The TOSOH G8 ion exchange high performance liquid chromatography analyzer (Photo courtesy of Tosoh Bioscience).

Lower HbA1c Levels Seen in Diabetic Liver Disease Patients

Diabetes is a leading cause of liver disease, with cirrhosis responsible for a considerable number of deaths in people with diabetes in the USA. The association is mediated by multiple mechanisms including dyslipidemia and altered hepatic fatty acid processing. More...
23 May 2019
Image: Sickle SCAN is a multiplexed qualitative point-of-care immunoassay used for the rapid diagnosis of sickle cell disorders. The test is made up of three indicators which detect the presence of hemoglobin A, S, and C, allowing the user to rapidly distinguish between normal, carrier, and sickle cell samples (Photo courtesy of BioMedomics).

Sickle Cell Disease Screening Helps Save Lives of Migrants

Sickle cell disease (SCD) is an inherited disorder that affects the production of hemoglobin, a protein in red blood cells that delivers oxygen to cells throughout the body. This abnormal hemoglobin can cause red blood cells to become rigid and sickle shaped. More...
21 May 2019
Image: The Bioanalyzer 2100 system is a microfluidic platform that provides quantitation and quality control of DNA and RNA by capillary electrophoresis (Photo courtesy of Agilent Technologies).

Multiple Myeloma Sequences Reveal Prognostic Immunoglobulin Translocation

Multiple myeloma is the second most common hematological cancer, which affects terminally differentiated antibody secreting B cells, known as plasma cells. Clinical manifestations of myeloma include hypercalcemia, anemia, renal failure, and lytic bone lesions. More...
08 May 2019
Image: Blood film of a patient with acute myelogenous leukemia defined by presence of more than 90% myeloblasts in blood and/or bone marrow (Photo courtesy of Pathpedia).

Protein Atlas Accelerates Personalized Medicine in Leukemia Patients

Acute myelogenous leukemia is associated with risk factors that are largely unknown and with a heterogeneous response to treatment. Only about one in four people diagnosed with acute myelogenous leukemia (AML) survive five years after the initial diagnosis. More...
30 Apr 2019
Image: The Early Sepsis Indicator kit was designed for use on automated hematology instruments such as the DxH 900 analyzer (Photo courtesy of Beckman Coulter).

Early Sepsis Detection Test Approved for U.S. Marketing

A test for the early detection of sepsis has been approved for marketing in the United States as an in vitro diagnostic product. More...
29 Apr 2019
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Antipsychotic TDM Assays
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.