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Molecular Diagnostics

Image: A human neutrophil (grey) is interacting with Klebsiella pneumoniae (pink). A hypervirulent version of this pathogen is sparking increasing concern due to recent reports describing hypervirulent strains that are antimicrobial resistant (Photo courtesy of National Institute of Allergy and Infectious Diseases).

Biomarker Discovered for Hypervirulent Pathogen

There is no accurate method for distinguishing between the hypervirulent strain from the classical strain of Klebsiella pneumoniae (cKp), which is most often seen in the Western hemisphere, and is less virulent and usually causes infections in hospital settings. More...
18 Jul 2018
Image: The structure of a lipopolysaccharide (Photo courtesy of Wikimedia Commons).

MicroRNA Pair Serves as Biomarkers for Rapid Sepsis Diagnosis

Two microRNAs that could be the basis of a test to help physicians classify patients into those with organ failure who are at high risk of sepsis and death and those patients with milder infections have been identified. More...
16 Jul 2018
Image: Reducing variability of quantitative suspension array assays is critical to the success of multi-center and large sero-epidemiological studies (Photo courtesy of Pau Fabregat).

Optimization of Analytical Procedures Reduces Variability of Results

A team of Spanish researchers recently described the development and optimization of several "quantitative suspension array" assays (qSAT) designed to assess natural and vaccine-induced responses to malaria and other parasites. More...
16 Jul 2018
Image: Genetic risk correlations among brain disorders and quantitative phenotypes (Photo courtesy of the Brainstorm Consortium).

Genetic Connections Uncovered Between Psychiatric Disorders

Brain disorders may exhibit shared symptoms and substantial epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed study of phenotypes with different ages of onset, severity, and presentation poses a considerable challenge. More...
12 Jul 2018
Image: Colonies of Pseudomonas aeruginosa on blood agar after cultivation for 48 hours at 37°C. Small, smooth colonies are Enterococcus faecalis (Photo courtesy of microbiologypictures).

Female Bladder Bacteria Reveal Urogenital Microbiota

Contrary to medical dogma, urine is not sterile, even in asymptomatic individuals. For over 60 years, the standard urine culture protocol has represented the primary tool for detecting bacteria in clinical microbiology laboratories. More...
11 Jul 2018
Image: The Accela liquid chromatography system (Photo courtesy of Thermo Fisher Scientific).

Lipid Species Offer Insights into Metabolic Health

Heart disease is the number one killer in the USA, and high triglyceride levels in the blood are cited as just one of several risk factors. Millions of lipid panels, blood tests that look at cholesterol levels as well as triglycerides, are performed in clinics each year. More...
11 Jul 2018
Image: A bronchial tube, cells stained red and blue are part of the bronchial epithelium, or lining. This demonstrates the existence among these cells of a rare cell type (stained blue-green), believed to be a tuft cell. The scientists have discovered a new type of lung cancer with origins in these cells, which overexpress a gene-regulating protein called POU2F3, a potential target for therapy (Photo courtesy of Cold Spring Harbor Laboratory).

New Genre of Small-Cell Lung Cancer Discovered

Small cell lung cancer (SCLC) is widely considered to be a tumor of pulmonary neuroendocrine cells; however, a variant form of this disease has been described that lacks neuroendocrine features. More...
10 Jul 2018
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.