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Molecular Diagnostics

Image: The Affymetrix GeneChip Human Genome U133 Plus 2.0 array (Photo courtesy of Thermo Fisher Scientific).

Novel Test Measures Pain Biomarkers in Blood

A test that objectively measures pain biomarkers in blood has been developed. The test could help physicians better treat patients with precision medicine, and help stem the tide of the opioid crisis. More...
05 Mar 2019
Image: A histopathology of the bile duct of a patient with biliary atresia: loss of bile ducts, brisk ductular reaction, and bile plugs (Photo courtesy of Hopkins GI Pathology).

Genetic Defect Linked to Pediatric Liver Disease

Biliary atresia (BA) is the most common cause of end‐stage liver disease in children and the primary indication for pediatric liver transplantation, yet underlying etiologies remain unknown. More...
04 Mar 2019
Image: The T8 Isothermal Diagnostics Instrument provides quantitative and qualitative results for molecular diagnostic isothermal assay applications (Photo courtesy of Axxin).

Buruli Ulcer Pathogen Detected by Isothermal RPA Assay

Buruli ulcer (BU) is a neglected tropical disease caused by Mycobacterium ulcerans. The pathogenesis of BU is linked to the production of a polyketide toxin known as mycolactone, which is cytotoxic and has immunomodulatory properties and presents as nodules, plaques, ulcers and edema. More...
28 Feb 2019
Image: A histopathology of gastric adenocarcinoma representing a signet ring cell variant identified in an endoscopic biopsy specimen (Photo courtesy of KGH).

Gastric Cancer Analysis Identifies Four Subtypes

In previous studies of gastric cancers (GCs), genomic and transcriptomic analyses have identified molecular signatures associated with phenotypes of the disease, such as patient subtypes and survival. New proteogenomic analysis of diffuse gastric cancers (GCs) in young populations identified four subtypes of the disease. More...
28 Feb 2019
Image: A fundus photo showing intermediate age-related macular degeneration (Photo courtesy of National Eye Institute).

Genes Associated with Age-Related Macular Degeneration Identified

Age-Related Macular Degeneration (AMD) is a complex disease influenced by yet-to-be-understood mix of genetic and behavioral factors. Smoking increases the risk of developing the disease, while eating leafy greens and fish reduces it. More...
26 Feb 2019
Image: The cf-DNA/cf-RNA Preservative tubes (Photo courtesy of Norgen Biotek).

Storage Tubes for Analysis of Circulating NAs Evaluated

Circulating nucleic acids such as microRNAs (miRNAs) and cell-free DNA (cfDNA) have become increasingly important in serving as potential novel biomarkers for a variety of human diseases. More...
26 Feb 2019
Image: The Nextera DNA Library Preparation Kit (Photo courtesy of Illumina).

Gene Missense Variant Associated with Crohn's Disease

Gene-microbiome interactions are important in etiology and pathogenesis of inflammatory bowel disease, a chronic inflammatory disorder of the gastrointestinal tract consisting of Crohn’s disease and ulcerative colitis. More...
21 Feb 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.