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Molecular Diagnostics

Image: The Twista device allows portable, two channel fluorometric detection of eight Recombinase Polymerase Amplification (RPA) reactions (Photo courtesy of TwistDx).

Rapid Molecular Test Detects Macrolide Resistance

Emerging antimicrobial resistance is a significant threat to human health. However, methods for rapidly diagnosing antimicrobial resistance generally require multi-day culture-based assays. More...
13 Mar 2019
Image: The Guardant360 kit for biopsy-free tissue sequencing for cancer (Photo courtesy of Guardant Health).

Liquid Biopsy Proves Effective as Biopsy for NSCLC

Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). NSCLC accounts for about 85% of all lung cancers. As a class, NSCLCs are relatively insensitive to chemotherapy, compared to small cell carcinoma. More...
13 Mar 2019
Image: A photomicrograph of a glomerulus with changes characteristic of a transplant glomerulopathy. Transplant glomerulopathy is considered a form of chronic antibody-mediated rejection (Photo courtesy of Nephron).

Blood Test Predicts Kidney Transplant Rejection

A renal transplant offers the best treatment for patients whose kidneys have failed, with around 3,000 carried out annually in the UK. Acute rejection occurs when the body's immune system begins to attack the donated organ. More...
12 Mar 2019
Image: Newly identified (red) and known (blue) genes linked to Alzheimer’s disease spike in this table plotting results from genome-wide association analysis of 94,437 individuals with late onset Alzheimer’s (Photo courtesy of Brian W. Kunkle, MD, PhD and colleagues).

Alzheimer's Disease Meta-Analysis Identifies New Risk Genes

The risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially driven by genetics. Scientists have uncovered five new late-onset Alzheimer's disease risk genes in a genetic meta-analysis. They likewise confirmed 20 other genes previously linked to late-onset Alzheimer's risk. More...
11 Mar 2019
Image: The QXDx BCR-ABL %IS kit and the QXDx AutoDG ddPCR system (Photo courtesy of Bio-Rad Laboratories).

Clinical ddPCR Diagnostic Test System Gets FDA Clearance

A test designed for monitoring treatment response in chronic myeloid leukemia and is also the first-ever digital polymerase chain reaction (PCR) product to receive US official government approval. More...
07 Mar 2019
Image: A blood smear of a patient with monoclonal B-cell lymphocytosis. The two atypical lymphocytes are mature with a small rim of basophilic cytoplasm and clumped or cracked chromatin (Photo courtesy of Elizabeth Courville, MD).

Circulating Plasma DNA Potentially Identifies Incipient Tumors

Early cancer diagnosis might improve survival rates. As circulating tumor DNA (ctDNA) carries cancer-specific modifications, it has great potential as a noninvasive biomarker for detection of incipient tumors. More...
06 Mar 2019
Image: Test strips of IMMY Cryptococcal Antigen Lateral Flow Assay kit (LFA) (Photo courtesy of the Institute for Medical Research, Kuala Lumpur, Malaysia).

Lateral Flow RPA Assay Developed for Cryptococcus in CSF

The most common presentations of cryptococcosis are meningitis and meningoencephalitis. Cryptococcal meningitis (CM) is a subacute meningoencephalitis and the most common cause of adult meningitis with very high mortality rates as well as vision and hearing loss in survivors. More...
06 Mar 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.