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Molecular Diagnostics

Image: Low levels of amyloid-beta and tau proteins in the vitreous humor were indicative of potential Alzheimer\'s disease risk (Photo courtesy of Wikimedia Commons).

AD Biomarkers in Ocular Fluid Indicate Dementia Risk

Measuring levels of amyloid-beta and tau proteins in the eye's vitreous humor has been suggested as means to detect dementia at an early stage in individuals at risk for Alzheimer's disease (AD). More...
25 Mar 2019
Image: An illustration of HLA-A complexed with HIV TAX peptide (Photo courtesy of Wikimedia Commons).

Reaction to Vancomycin Linked to Immune System HLA Variant

A simple and inexpensive assay for the HLA-A*32:01 genetic variant was developed for routine use in diagnostic laboratories to identify patients likely to suffer from vancomycin-associated drug rash with eosinophilia and systemic symptoms (DRESS). More...
25 Mar 2019
Image: The CFX96 real-time polymerase chain reaction detection system (Photo courtesy of Bio-Rad).

Fast Diagnosis of Sporotrichosis Based on RT-PCR

Sporotrichosis is a subacute or chronic infectious disease caused by dimorphic fungi of Sporothrix spp. The genus Sporothrix consists of several species with different geographic distributions, virulence, and antifungal susceptibilities, making species-level identification necessary. More...
21 Mar 2019
Image: A histopathology of clear cell papillary renal cell carcinoma (Photo courtesy of Nephron).

Five-Gene Signature Predicts Survival from Renal Cell Carcinoma

Papillary renal cell carcinomas include type 1 lesions, which are characterized by small cells in single layers and scanty cytoplasm and type 2 lesions, which are distinguished by larger cells, pseudo-stratified nuclei, and voluminous eosinophilic cytoplasm. More...
20 Mar 2019
Image: The TruSight Tumor 15 uses next-generation sequencing (NGS) technology to provide a comprehensive assessment of 15 genes that are commonly mutated in solid tumors (Photo courtesy of Illumina).

EBUS More Reliable Than Histology for Cancer Diagnoses

Radial probe endobronchial ultrasound (EBUS) is a minimally invasive procedure that improves localization of peripheral pulmonary lesions. Cytology samples of the suspect lesion site collected by radial EBUS bronchoscopy provides good diagnostic sensitivity estimated at 73%, whereas histology does not definitely diagnose malignancy in approximately 20% cases. More...
20 Mar 2019
Image: Researchers combined graphene with nano-sized metal ribbons of gold to create an ultrasensitive biosensor that could help detect a variety of diseases in humans and animals (Photo courtesy of Oh Group, University of Minnesota).

Researchers Lay Groundwork for Graphene-based Diagnostic Devices

A breakthrough in the use of graphene as a plasmon resonator for ultrasensitive infrared spectroscopy should enable development of new biosensors for detection of diseases at the molecular level. More...
18 Mar 2019
Image: A new study identified 76 new gene regions associated with sleep duration (Photo courtesy of CCO Public Domain).

New Genetic Loci Link to Insufficient and Excessive Sleep Duration

Genetic loci have been found that are linked to either abnormally long or short sleep duration. More...
18 Mar 2019
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.