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Molecular Diagnostics

Image: The Genome-wide Association Studies fact sheet (Photo courtesy of the National Human Genome Research Institute).

Genes behind Gestation Length and Preterm Delivery Identified

Despite evidence that genetic factors contribute to the duration of gestation and the risk of preterm birth, robust associations with genetic variants have not been identified. Preterm birth and gestational duration in general, is a complicated phenotype that is affected by both maternal and fetal genomes. More...
21 Sep 2017
Image: A histopathology of pancreatic ductal adenocarcinoma. A moderately differentiated adenocarcinoma shows encircling of an islet and stromal desmoplasia. The desmoplasia is manifested by fibromyxoid stroma with a haphazard arrangement of cells (Photo courtesy of Pathpedia).

Combination Liquid Biopsy Diagnoses Early Cancer

Few patients with pancreatic cancer survive longer than five years, in part because most patients are identified only after their disease has progressed to an advanced stage. Most early-stage pancreatic cancers are found incidentally during an imaging scan and generally cause no symptoms. More...
20 Sep 2017
Image: Liquid Biopsy: Solid tumor masses may shed (1) circulating tumor DNA (ctDNA) and circulating tumor RNA (ctRNA), (2) apoptotic circulating tumor cells (CTCs), or (3) intact CTCs into the circulation. In addition, ctDNA and ctRNA may enter the bloodstream after apoptosis of circulating and non-circulating tumor cells (4) (Photo courtesy of H. McDonald / Science Translational Medicine).

Liquid Biopsy Test Launched for NRAS Mutations

The NRAS gene encodes for the N-Ras protein, which is involved in communicating signals from the exterior of the cell to the cell's interior (called signal transduction). These signals provide instructions for a cell to proliferate or differentiate. More...
20 Sep 2017
Image: The Tumor Mutation Burden test detects cell free tumor DNA in the blood and allows for stratification of patients not eligible to have a tumor biopsy (Photo courtesy of the US National Cancer Institute).

Blood Test Predicts Immunotherapy Efficacy

A test developed with the US-based genetic testing specialist could be significant because, although potent, it is difficult to predict which patients will respond to immunotherapies, which are setting new care standards in some types of tumors. More...
20 Sep 2017
Image: A human malignant melanoma cell viewed through a fluorescent, laser-scanning confocal microscope. Invasive structures involved in metastasis appear as greenish-yellow dots, while actin (green) and vinculin (red) are components of the cell’s cytoskeleton (Photo courtesy of Vira V. Artym, PhD, PMP).

Early Stage Melanoma Identified by Simple Blood Test

Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes. Melanomas typically occur in the skin but may rarely occur in the mouth, intestines, or eye. More...
20 Sep 2017
Image: An ATR attachment for infrared spectroscopy. The sample is in the steel containers either side of the pink crystal (Photo courtesy of Wikimedia Commons).

Direct Spectroscopy Used for Diagnosis of Neurodegenerative Disorders

Advanced spectroscopy methods were used to establish a direct diagnostic test for Alzheimer's disease and other types of neurodegenerative disorders. More...
19 Sep 2017
Image: A scanning electron micrograph (SEM) of prostate cancer cells (Photo courtesy of David McCarthy).

Tumor Marker Levels Serve As Indicators of Disease Progression

Measuring serum levels of tumor markers may serve as an early indicator of the progression of established tumors in the face of ongoing treatment. More...
19 Sep 2017
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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