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Molecular Diagnostics

Image: Illustration of the heart with magnification of the artery (Photo courtesy of American Heart Association)

Large Genome-Wide Association Study Identifies Novel Abdominal Aortic Aneurysm Risk Loci

A recent report identified novel genetic associations for abdominal aortic aneurysm (AAA) with therapeutic implications and identified a subset of the population at significantly increased genetic risk of AAA that was independent of family history. More...
05 Oct 2020
Image: Cryptosporidium oocysts and the larger Giardia cysts stained by Crypto/Giardia IFA kit (Photo courtesy of Cellabs).

Smartphone Microscopic Method Detects Cryptosporidium and Giardia

Food and water-borne illness arising from the consumption of contaminated food and water are serious health hazards globally. Cryptosporidium and Giardia are the major food and water‒borne parasites. The infection occurs mainly by (oo)cyst phase of the parasites. More...
30 Sep 2020
Image: Various types of data analysis using BeadStudio Methylation Module with Illumina`s MethylationEpic array (Photo courtesy of Phoebe Lu).

Epigenetic Markers Predict Type 2 Diabetes Patients Response to Metformin

Generally, metformin is the first medication prescribed for type 2 diabetes (T2D). It works by lowering glucose production in the liver and improving the body's sensitivity to insulin so that the body uses insulin more effectively. Currently, there are no phenotypes that successfully predict glycemic response to, or tolerance of, metformin. More...
29 Sep 2020
Image: The Chromium Controller rapidly and efficiently combines large partition numbers with a massively diverse barcode library to generate >100,000 barcode-containing partitions in a matter of minutes. (Photo courtesy of 10x Genomics)

Endometrium Undergoes Gene Expression Shifts During Menstrual Cycle

In a human menstrual cycle the endometrium undergoes remodeling, shedding and regeneration, all of which are driven by substantial gene expression changes in the underlying cellular hierarchy. More...
29 Sep 2020
Image: A field-applicable, ultrasensitive diagnostic assay specifically detects DNA and RNA sequences from all Plasmodium species in symptomatic and asymptomatic malaria, and delivers its results fast in simple reporter devices (Photo courtesy of Peter Nguyen, Harvard University)

Rapid One-Step Assay for Field-Based Detection of Asymptomatic Malaria

A novel CRISPR-based ultrasensitive assay system was able to detect the four major types of malaria-causing parasites and has been streamlined for use in locations lacking the advanced laboratory equipment and highly trained technicians required for tests such as RT-qPCR, which is used extensively for monitoring the COVID-19 pandemic. More...
29 Sep 2020
Image: Scanning electron microscope (SEM) image showing SARS-CoV-2 (round gold objects) emerging from the surface of laboratory cultured cells (Photo courtesy of [U.S.] National Institute of Allergy and Infectious Diseases)

One-Step CRISPR-Based Assay Could Streamline COVID-19 Testing

An advanced CRISPR-based diagnostic test for COVID-19 produces results in 30 to 60 minutes, with accuracy similar to the standard CDC (Centers for Disease Control and Prevention) RT- qPCR test now in routine use. More...
28 Sep 2020
Image: Photomicrograph of histopathology of Barrett`s esophagus showing the characteristic goblet cells (Alcian blue stain) (Photo courtesy of Nephron).

Genomic Copy Number Predicts Esophageal Cancer Years Before Transformation

Barrett’s esophagus is a condition in which the lining of the esophagus changes, becoming more like the lining of the small intestine rather than the esophagus. This occurs in the area where the esophagus is joined to the stomach. More...
23 Sep 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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