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Molecular Diagnostics

Image: Histopathology of kidney disease: showing completely sclerotic glomeruli and severe chronic tubulointerstitial nephritis (Photo courtesy of Jian-Hua Qiao, MD, FCAP).

Urinary Metabolite GWAS Leads to Biomarkers of Kidney Disease

 The kidneys integrate information from continuous systemic processes related to the absorption, distribution, metabolism and excretion (ADME) of metabolites. Scientists have identified ties between urine metabolite levels and common genetic variants, laying the foundation for a more refined view of human metabolic processes and the tissues in which they take place. More...
04 Feb 2020
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Blood Test Measuring anti-Müllerian Hormone Predicts Time to a Woman’s Final Menstrual Period

 A blood test has been developed that helps predict the time to a woman’s final menstrual period (FMP). More...
04 Feb 2020
Image: Photomicrograph of cancer cells (Photo courtesy of Baylor College of Medicine)

A Needle Biopsy-based Proteogenomics Approach for Cancer Diagnosis

 A recent report described a proteogenomics approach for cancer diagnosis, which used tissue-sparing needle biopsy specimen processing and micro-scaled analytical proteomics techniques. More...
04 Feb 2020
Image: Kidney specimen from patient who died with acute kidney injury. Image shows marked pallor of the cortex, contrasting to the darker areas of surviving medullary tissue (Photo courtesy of Wikimedia Commons)

Proteinuria After Acute Kidney Injury Predicts Development of Progressive Disease

 A report has suggested that testing recently hospitalized kidney patients for proteinuria could be a way to identify those at higher risk for developing progressive kidney disease, which could require dialysis or surgery. More...
03 Feb 2020
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Large Number of Genes Linked to Risk of Developing Autism Spectrum Disorder

 A large exome sequencing study of autism spectrum disorder identified 102 genes associated with risk for autism. More...
03 Feb 2020
Image: Dark field microscopy of a culture of blood in EMJH semisolid media showing spirochetes with morphology compatible with Leptospira (Photo courtesy of Alejandro Llanes).

Multivariable Diagnostic Prediction Score Validated for Leptospirosis

 Leptospirosis is a bacterial disease that affects humans and animals. It is caused by bacteria of the genus Leptospira. In humans, it can cause a wide range of symptoms, some of which may be mistaken for other diseases. More...
30 Jan 2020
Image: The DS-11 Series of Spectrophotometers are used to perform fast quantification of nucleic acids and proteins (Photo courtesy of DeNovix).

Homologous Recombination Defects Prevalent in African-American Cancer Patients

 In the USA, African-Americans have the highest cancer incidence and lowest survival across multiple cancer types. The reasons for these persistent trends are not clear. More...
28 Jan 2020
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