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Molecular Diagnostics

Image: The Guardant360 tests 74 genes in a blood sample to identify the presence of spot tumor mutations, reordering, insertions and deletions (indels), as well as microsatellite instability (Photo courtesy of MygeneLab).

Circulating Tumor DNA Analysis Directs Therapy in Breast Cancer

Multiple tumor mutations are potentially targetable for advanced breast cancer treatment. Some of these mutations are common, such as activating PIK3CA mutations that are targetable with PI3K inhibitors. More...
22 Sep 2020
Image: The Aedes aegypti mosquito can spread various tropical diseases including dengue, zika, and chikungunya, which have similar symptoms (Photo courtesy of Gwangju Institute of Science and Technology)

A Paper-Based Nucleic Acid Testing Device for Rapid Diagnosis of Mosquito-Borne Viral Diseases

An all-in-one nucleic acid testing device loaded into a paper chip forms the basis for a simple, rapid diagnostic test for a range of mosquito-borne viral diseases. More...
22 Sep 2020
Image: The QX200 droplet digital polymerase chain reaction (ddPCR) instrument (Photo courtesy of Bio-Rad).

Click Chip’ Detects Early-Stage Liver Cancer Biomarkers in Extracellular Vesicles

 Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related deaths worldwide. The poor prognosis of HCC can be attributed to the fact that diagnosis is often made at a late stage in disease development. More...
21 Sep 2020
Image: Upconverting nanoparticles: With the combination of NIR-excitation (980 nanometers) and detection at a lower wavelength, the autofluorescence from biological samples is totally eliminated, and the particles are detectable through tissue sections and even in whole blood (Photo courtesy of Kaivogen Oy)

Novel Rapid Lateral Flow Assay Measures Ovarian Cancer Biomarker CA125

A radically modified lateral flow immunoassay was able to detect the ovarian cancer biomarker glycosylated CA125 in serum samples and rapidly differentiate epithelial ovarian cancer from benign endometriosis and healthy controls. More...
21 Sep 2020
Image: Illustration depicting the marriage of DNA nanotechnology and bioelectronics (Photo courtesy of EatFishDesign)

Biosensing Platform Diagnoses Diseases Through Single Molecule Detection

A new diagnostic approach employs a DNA origami biosensor platform coupled with a nanopore read-out that enables individual biomarker detection. More...
15 Sep 2020
Image: Histopathology of the coronary artery demonstrating an intramural hematoma compressing the vessel lumen from outside from a patient with spontaneous coronary artery dissection (Photo courtesy of Professor Mary N Sheppard, MBBCh FRCPath).

Genetics Influence Risk for Spontaneous Coronary Artery Dissection

Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of myocardial infarction (MI) in young and otherwise healthy women, for which the etiology is incompletely understood. More...
14 Sep 2020
Image: Using advanced biochemical analysis of patient serum, researchers found signatures that help predict which patients are at highest risk of dying from S. aureus bacteremia, a blood infection (Photo courtesy of University of California, San Diego)

Proteomics-Based Diagnostic Test Predicts Risk of Dying from Staphylococcus aureus Bacteremia

A diagnostic approach that integrates proteomic and metabolomic techniques enabled the identification of biomarkers that could predict which patients had the highest risk of dying from Staphylococcus aureus bacteremia. More...
14 Sep 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.