Digital Slide Imaging Evaluated for Cervicovaginal Cytology
|
By LabMedica International staff writers Posted on 26 Jun 2013 |
|
Image: BioImagene digital scanner (Photo courtesy of Ventana Medical Systems).
Digital imaging is the creation, storage, and transmission of an image file using a computer and is considered by many to be the future of anatomic pathology.
Whole slide imaging has been successfully used in surgical pathology, but its usefulness and clinical application have been limited in cytology for several reasons, including lack of availability of z-axis depth focusing and large file size.
Cytopathologists at The Methodist Hospital (Houston, TX, USA) investigated the accuracy and efficiency of whole slide imaging, as compared with traditional glass slides, for use in cervicovaginal diagnostic cytology. Eleven cervicovaginal cytology cases were evaluated by four cytotechnologists and three cytopathologists in a blinded study. Digitally scanned images were reviewed first, and different magnification scans were presented as separate cases in a random order. Corresponding glass slides were also reviewed and for each case, the diagnoses and total time to reach each diagnosis were recorded.
The specimens were prepared using both ThinPrep (BD Diagnostics TriPath; Burlington, NC, USA) and SurePath (Hologic Inc.; Marlborough, MA, USA). All the cases were scanned using the BioImagene iScan Coreo Au 3.0 scanner (Ventana Medical Systems Inc.; Sunnyvale, CA, USA). Diagnostic accuracy was higher and average time per case was lower with glass slides as compared with all digital images. Accuracy of interpretation of the digital images was best achieved with ×40 magnification, and z-stack digital images scanned at ×40 magnification improved the accuracy of diagnosis in one case of adenocarcinoma of the endometrium.
The authors concluded that whole slide imaging is a viable option for the purposes of teaching and consultations, and as a means of archiving cases. However, considering the large file size and total time to reach diagnosis on digital images, they consider whole slide imaging may not yet be ready as a daily screening tool in cervicovaginal diagnostic cytology. The study was published in the May 2013 edition of the journal Archives of Pathology & Laboratory Medicine.
Related Links:
The Methodist Hospital
BD Diagnostics
Ventana Medical Systems
Whole slide imaging has been successfully used in surgical pathology, but its usefulness and clinical application have been limited in cytology for several reasons, including lack of availability of z-axis depth focusing and large file size.
Cytopathologists at The Methodist Hospital (Houston, TX, USA) investigated the accuracy and efficiency of whole slide imaging, as compared with traditional glass slides, for use in cervicovaginal diagnostic cytology. Eleven cervicovaginal cytology cases were evaluated by four cytotechnologists and three cytopathologists in a blinded study. Digitally scanned images were reviewed first, and different magnification scans were presented as separate cases in a random order. Corresponding glass slides were also reviewed and for each case, the diagnoses and total time to reach each diagnosis were recorded.
The specimens were prepared using both ThinPrep (BD Diagnostics TriPath; Burlington, NC, USA) and SurePath (Hologic Inc.; Marlborough, MA, USA). All the cases were scanned using the BioImagene iScan Coreo Au 3.0 scanner (Ventana Medical Systems Inc.; Sunnyvale, CA, USA). Diagnostic accuracy was higher and average time per case was lower with glass slides as compared with all digital images. Accuracy of interpretation of the digital images was best achieved with ×40 magnification, and z-stack digital images scanned at ×40 magnification improved the accuracy of diagnosis in one case of adenocarcinoma of the endometrium.
The authors concluded that whole slide imaging is a viable option for the purposes of teaching and consultations, and as a means of archiving cases. However, considering the large file size and total time to reach diagnosis on digital images, they consider whole slide imaging may not yet be ready as a daily screening tool in cervicovaginal diagnostic cytology. The study was published in the May 2013 edition of the journal Archives of Pathology & Laboratory Medicine.
Related Links:
The Methodist Hospital
BD Diagnostics
Ventana Medical Systems
Gold Member
Hematology Analyzer
Medonic M32B
Sample Transportation System
Tempus1800 Necto
Automatic Hematology Analyzer
DH-800 Series
Latest Pathology News
- First-Of-Its-Kind Test Identifies Autism Risk at Birth
- AI Algorithms Improve Genetic Mutation Detection in Cancer Diagnostics
- Skin Biopsy Offers New Diagnostic Method for Neurodegenerative Diseases
- Fast Label-Free Method Identifies Aggressive Cancer Cells
- New X-Ray Method Promises Advances in Histology
- Single-Cell Profiling Technique Could Guide Early Cancer Detection
- Intraoperative Tumor Histology to Improve Cancer Surgeries
- Rapid Stool Test Could Help Pinpoint IBD Diagnosis
- AI-Powered Label-Free Optical Imaging Accurately Identifies Thyroid Cancer During Surgery
- Deep Learning–Based Method Improves Cancer Diagnosis
- ADLM Updates Expert Guidance on Urine Drug Testing for Patients in Emergency Departments
- New Age-Based Blood Test Thresholds to Catch Ovarian Cancer Earlier
- Genetics and AI Improve Diagnosis of Aortic Stenosis
- AI Tool Simultaneously Identifies Genetic Mutations and Disease Type
- Rapid Low-Cost Tests Can Prevent Child Deaths from Contaminated Medicinal Syrups
- Tumor Signals in Saliva and Blood Enable Non-Invasive Monitoring of Head and Neck Cancer
Channels
Clinical Chemistry
view channel
New PSA-Based Prognostic Model Improves Prostate Cancer Risk Assessment
Prostate cancer is the second-leading cause of cancer death among American men, and about one in eight will be diagnosed in their lifetime. Screening relies on blood levels of prostate-specific antigen... Read more
Extracellular Vesicles Linked to Heart Failure Risk in CKD Patients
Chronic kidney disease (CKD) affects more than 1 in 7 Americans and is strongly associated with cardiovascular complications, which account for more than half of deaths among people with CKD.... Read more
Molecular Diagnostics
view channel
New Tool Maps Chromosome Shifts in Cancer Cells to Predict Tumor Evolution
As tumors grow, cancer cells constantly make errors during DNA copying and division. Many of these errors involve the gain or loss of entire chromosomes, resulting in a diverse range of chromosome configurations... Read more
World's First Blood Test Distinguishes Between Benign and Cancerous Lung Nodules
Lung cancer remains the deadliest cancer in China, largely because many patients are diagnosed at an advanced stage when treatment options are limited. Early symptoms are often mild or absent, and while... Read more
Hematology
view channel
New Guidelines Aim to Improve AL Amyloidosis Diagnosis
Light chain (AL) amyloidosis is a rare, life-threatening bone marrow disorder in which abnormal amyloid proteins accumulate in organs. Approximately 3,260 people in the United States are diagnosed... Read more
Fast and Easy Test Could Revolutionize Blood Transfusions
Blood transfusions are a cornerstone of modern medicine, yet red blood cells can deteriorate quietly while sitting in cold storage for weeks. Although blood units have a fixed expiration date, cells from... Read more
Automated Hemostasis System Helps Labs of All Sizes Optimize Workflow
High-volume hemostasis sections must sustain rapid turnaround while managing reruns and reflex testing. Manual tube handling and preanalytical checks can strain staff time and increase opportunities for error.... Read more
High-Sensitivity Blood Test Improves Assessment of Clotting Risk in Heart Disease Patients
Blood clotting is essential for preventing bleeding, but even small imbalances can lead to serious conditions such as thrombosis or dangerous hemorrhage. In cardiovascular disease, clinicians often struggle... Read moreImmunology
view channel
Blood Test Identifies Lung Cancer Patients Who Can Benefit from Immunotherapy Drug
Small cell lung cancer (SCLC) is an aggressive disease with limited treatment options, and even newly approved immunotherapies do not benefit all patients. While immunotherapy can extend survival for some,... Read more
Whole-Genome Sequencing Approach Identifies Cancer Patients Benefitting From PARP-Inhibitor Treatment
Targeted cancer therapies such as PARP inhibitors can be highly effective, but only for patients whose tumors carry specific DNA repair defects. Identifying these patients accurately remains challenging,... Read more
Ultrasensitive Liquid Biopsy Demonstrates Efficacy in Predicting Immunotherapy Response
Immunotherapy has transformed cancer treatment, but only a small proportion of patients experience lasting benefit, with response rates often remaining between 10% and 20%. Clinicians currently lack reliable... Read more
Microbiology
view channel
AI-Powered Platform Enables Rapid Detection of Drug-Resistant C. Auris Pathogens
Infections caused by the pathogenic yeast Candida auris pose a significant threat to hospitalized patients, particularly those with weakened immune systems or those who have invasive medical devices.... Read more
New Test Measures How Effectively Antibiotics Kill Bacteria
Antibiotics are typically evaluated by how well they inhibit bacterial growth in laboratory tests, but growth inhibition does not always mean the bacteria are actually killed. Some pathogens can survive... Read more
Technology
view channel
Robotic Technology Unveiled for Automated Diagnostic Blood Draws
Routine diagnostic blood collection is a high‑volume task that can strain staffing and introduce human‑dependent variability, with downstream implications for sample quality and patient experience.... Read more
ADLM Launches First-of-Its-Kind Data Science Program for Laboratory Medicine Professionals
Clinical laboratories generate billions of test results each year, creating a treasure trove of data with the potential to support more personalized testing, improve operational efficiency, and enhance patient care.... Read more
Aptamer Biosensor Technology to Transform Virus Detection
Rapid and reliable virus detection is essential for controlling outbreaks, from seasonal influenza to global pandemics such as COVID-19. Conventional diagnostic methods, including cell culture, antigen... Read more
AI Models Could Predict Pre-Eclampsia and Anemia Earlier Using Routine Blood Tests
Pre-eclampsia and anemia are major contributors to maternal and child mortality worldwide, together accounting for more than half a million deaths each year and leaving millions with long-term health complications.... Read moreIndustry
view channel
Diasorin and Fisher Scientific Enter into US Distribution Agreement for Molecular POC Platform
Diasorin (Saluggia, Italy) has entered into an exclusive distribution agreement with Fisher Scientific, part of Thermo Fisher Scientific (Waltham, MA, USA), for the LIAISON NES molecular point-of-care... Read more
