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Technology

Image: The Ammonia Breath test: the sensing system included a desiccation cylinder, an airtight sensing chamber, a rotameter, a pump, and an electrical signal measurement instrument (Photo courtesy of Chang Gung University).

Breath Ammonia Biomarker Predicts Kidney Function in CKD Patients

Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney function over a period of months to years. Initially there are generally no symptoms; later, symptoms may include leg swelling, feeling tired, vomiting, loss of appetite, and confusion. More...
18 Nov 2020
Image: Fibrinogen Test: people with low fibrinogen levels show a rapid movement of blood up the device (Photo courtesy of Monash University).

Paper Diagnostic Directly Measures Fibrinogen in Whole Blood

Fibrinogen is a protein found in blood that is needed for clotting. When a patient experiences traumatic injury, such as a serious car accident, or major surgery and childbirth complications, fibrinogen is required in their blood to prevent major hemorrhaging and death from blood loss. More...
10 Nov 2020
Image: The HM-JACKarc analytical system is a compact bench top system that uses Integrated Sphere Latex Turbidimetry to measure fecal hemoglobin concentration using a highly sensitive latex reagent coated with polyclonal antibodies to human hemoglobin (Photo courtesy of Hitachi Chemical Diagnostics Systems).

Fecal Immunochemical Test Assessed in Suspected Colorectal Cancer

Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, is the development of cancer from the colon or rectum (parts of the large intestine). Signs and symptoms may include blood in the stool, a change in bowel movements, weight loss, and fatigue. More...
05 Nov 2020
Image: A molecular-scale illustration of single-atom nanoyzmes and their application as a signal labels in an immunoassay. On the left, illustration of a protein biomarker being captured and detected in an immunoassay (Photo courtesy of Washington State University)

Artificial Enzyme Increases Sensitivity of Alzheimer's Disease Immunoassay

A novel modification made to the classic ELISA method for detecting the Alzheimer's disease biomarker amyloid beta 1-40 increased the sensitivity of the test by more than a factor of 10. More...
03 Nov 2020
Image: The signal of SMOLT is generated by the displacement of micron-size beads tethered by DNA long-probes that are between 1 and 7 microns long. The molecular extension of thousands of DNA probes is determined with sub-micron precision using a robust, rapid and low-cost optical approach (Photo courtesy of Scanogen).

Single-Molecule Tethering Detects Nucleic Acids and Microorganisms

Detection of microbial nucleic acids in body fluids has become the preferred method for rapid diagnosis of many infectious diseases. However, culture-based diagnostics that are time-consuming remain the gold standard approach in certain cases, such as sepsis. More...
29 Oct 2020
Image: An Acousto Thermal Shift Assay `lab-on-a-chip` device shown next to a US quarter for size comparison. The device can diagnose sickle cell anemia (Photo courtesy of CU Boulder College of Engineering and Applied Science).

New Technology Rapidly Diagnoses Sickle Cell Disease

Sickle cell disease (SCD) is a group of blood disorders typically inherited from a person's parents. The most common type is known as sickle cell anemia (SCA). It results in an abnormality in the oxygen-carrying protein hemoglobin found in red blood cells. More...
29 Oct 2020
Image: A recently developed electrochemical bio‐barcode device paired with a smartphone enables cancer patients to read critical biomarker levels at home in samples of self-drawn blood (Photo courtesy of Georgia Kirkos, McMaster University)

An Electrochemical Bio-barcode Device for Home Disease Monitoring and Diagnosis

A point-of-care (POC) electrochemical bio‐barcode device and assay system have been developed to enable analysis of protein biomarkers in undiluted and unprocessed human plasma samples. More...
28 Oct 2020
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LabMedica's Lab Technology channel informs on laboratory medicine techniques, while keeping an eye on new hardware, LIM software, consumables, and lab trends, techniques and safety.