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Microbiology

Image: Opisthorchiasis-associated cholangiocarcinoma. (A) Cholangiocarcinoma specimen showing adult worms in the bile duct (blue arrows). (B) Adult Opisthorchis viverrini recovered from the liver (Photo courtesy of Khon Kaen University)

Diagnostic Biomarker Predicts Risk of Opisthorchiasis Cholangiocarcinoma

Opisthorchiasis is caused by an infection with fish-borne liver flukes of the genus Opisthorchis. Opisthorchiasis frequently leads to chronic inflammation in the biliary tract and is classified as a group 1 biological carcinogen by the International Agency for Research on Cancer: a definitive risk for cholangiocarcinoma (CCA). More...
10 Mar 2022
Image: A `lab-in-a-box`, the PLUM reader (Portable, Low-cost, User-friendly, Multimode), presents results from up to 384 patient samples and displays them in a single image capture (Photo courtesy of Livia Guo, LSK Technologies)

Paper-Based Portable Diagnostic Platform Accurately Detects Mosquito-Borne Diseases Under Field Conditions

Field trails conducted in Latin America have shown that a paper-based portable diagnostic platform could accurately detect patients with mosquito-borne diseases with sensitivities equivalent to laboratory PCR tests. More...
09 Mar 2022
Image: The STANDARD G6PD Test is a low-cost, simple device developed to guide treatment of patients with malaria and support malaria elimination programs (Photo courtesy of SD BIOSENSOR/PATH)

Repeatability And Reproducibility of a Handheld Quantitative G6PD Diagnostic

Novel treatment regimens for the radical cure of P. vivax malaria are more effective than current options but require prior quantitative G6PD testing. The reference method for quantitative G6PD measurement is spectrophotometry but, due to its operational characteristics, is not suitable for routine use. Furthermore, poor inter-laboratory reproducibility of spectrophotometry has prevented quantitative global definitions of G6PD deficiency. SD Biosensor (ROK) have developed a novel handheld “Biosensor” device (G6PD STANDARD), which measures G6PD activity within two minutes and has operational characteristics suited to point of care diagnosis. More...
03 Mar 2022
Image: A medical illustration of Clostridioides difficile bacteria (Photo courtesy of Jennifer Oosthuizen, MA)

C. Difficile Colonization Among Children in Resource-Limited Settings

This study describes the epidemiology and risk factors for colonization among children in the etiology, risk factors, and interactions of enteric infections and malnutrition. Also explored was whether C. difficile detection contributed to longer-term health outcomes. More...
02 Mar 2022
Image: The BD Accuri C6 Plus Flow Cytometer (Photo courtesy of BD Biosciences)

Microbiome and Metabolome Features Characterized for the Cardiometabolic Disease Spectrum

Scientists have already discovered that the gut microbiome is altered in people with chronic heart disease. They subsequently identified compounds that are produced by the diseased microbiome, for instance a bacterial compound called trimethylamine (TMA) that after modification in the liver of the human host causes arteriosclerosis. More...
28 Feb 2022
Image: The Xpert Xpress Flu/RSV Assay is intended as an aid in the diagnosis of influenza and respiratory syncytial virus infections (Photo courtesy of Cepheid)

P-O-C Assay Detects Respiratory Syncytial Virus in Older Adults

The point-of-care Xpert Xpress Flu/RSV test appeared nearly as accurate as routine real-time RT-PCR for detecting respiratory syncytial virus (RSV) infections in older adults, a Dutch study found. More...
22 Feb 2022
Image: Oxford Nanopore Technologies’ MinIon sequencer is the only portable real-time device for DNA and RNA sequencing (Photo courtesy of Bradley Kroner (RDECOM)

New Pathogen Detection Assay Pairs Molecular Inversion Probes, Next-Generation Sequencing

Next-generation sequencing is rapidly finding footholds in numerous microbiological fields, including infectious disease diagnostics. Molecular inversion probe (MIP) technology can be coupled with next-generation sequencing (NGS) for targeted, multiplexed pathogen detection. More...
21 Feb 2022
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The LabMedica Microbiology channel provides the latest news in the fields of epidemiology, bacteriology, virology, and parasitology, all viewed from the unique perspective of Laboratory Medicine.
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