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Immunology

Image: Diversity of peripheral blood human NK cells identified by single-cell RNA sequencing (Photo courtesy of University of Manchester).

Human NK Cells Identified by Single-Cell RNA Sequencing

Natural killer (NK) cells are cytotoxic lymphocytes that are crucial for viral defense as well as detecting and killing cancer cells. This cell type is therefore of great interest for cancer immunotherapy. More...
27 Apr 2020
Image: Histology of multinucleated giant cells engulfing calcium oxalate crystals from a patient with type 1 primary hyperoxaluria (Photo courtesy of Jonathan E. Zuckerman, MD, PhD).

Biomarker Panel Evaluated for Primary Hyperoxaluria Patients

Primary hyperoxaluria (PH) is a group of autosomal recessive disorders characterized by recurrent urinary stones and nephrocalcinosis. Roughly half of PH patients present with advanced chronic kidney disease (CKD) at the time of diagnosis. More...
27 Apr 2020
Image: The Lymphoprep Tube is a sterile tube in that contains the Lymphoprep (separation medium) under a plastic filter disc. This is a simple and effective protocol most commonly used to isolate mononuclear cells (PBMCs) from human blood (Photo courtesy of Axis-Shield).

Functional Comparison of Different Tubes for Isolating Mononuclear Cells

Profiling of immune cells with single-cell technologies is a key component of both basic science studies, evaluation of therapeutics in clinical trials, and clinical care. Cryopreserved human peripheral blood mononuclear cells (PBMCs) are a commonly used sample type for a variety of immunological assays. More...
23 Apr 2020
Image: Mass cytometry with Helios uses CyTOF technology to enable deep profiling of translational and clinical samples across a range of cell surface and intracellular markers (Photo courtesy of Fluidigm).

Missing BAP1 Gene Associated with Immunosuppressive Molecules in Uveal Melanoma

Uveal melanoma is a cancer (melanoma) of the eye involving the iris, ciliary body, or choroid (collectively referred to as the uvea). Tumors arise from the pigment cells (melanocytes) that reside within the uvea and give color to the eye. More...
22 Apr 2020
Image: An enzyme-linked immunosorbent assay (ELISA) kit for the diagnosis of visceral leishmaniasis in humans (Photo courtesy of Bordier Affinity Products)

Commercial Kits Evaluated for Mediterranean Visceral Leishmaniasis

Human visceral leishmaniasis (VL) is a neglected disease endemic in the Mediterranean region, caused by Leishmania infantum. Accurate VL diagnosis is critical for rapid and correct patient management. Dogs are the main reservoir of L. infantum parasites that are transmitted to humans by the bite of infected phlebotomine sand flies. More...
16 Apr 2020
Image: The HISCL-5000 is a fully automated immunoassay analyzer with a throughput of 200 tests per hour (Photo courtesy of Sysmex).

Novel Glycoprotein Biomarker Evaluated for Liver Fibrosis

The main pathological consequence of chronic liver diseases is the continuous deposition of collagen fibers, which causes progressive liver fibrosis, and eventually cirrhosis. Mild‐to‐moderate fibrosis is rarely diagnosed because the disease is asymptomatic in the early stage. More...
13 Apr 2020
Image: The BD FACSCalibur fluorescent activated cell sorter platform allows users to perform both cell analysis and cell sorting in a single benchtop system (Photo courtesy of BD Biosciences).

sTNFR2 Revealed as a Novel Diagnostic Biomarker for Acute ATL

Adult T-cell leukemia/lymphoma (ATL) is a mature T-cell neoplasm associated with human T-cell leukemia virus type 1 (HTLV-1). Although only about 5% of HTLV-1 carriers progress to ATL, early diagnosis is challenging because of the lack of ATL biomarkers. Soluble tumor necrosis factor 2 (sTNFR2) is a novel and promising diagnostic biomarker for acute ATL. More...
07 Apr 2020
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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