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Immunology

Image: Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations (Photo courtesy of Cornell University)

Immune System Altered in Chronic Fatigue Syndrome

 Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe, chronic, and debilitating disease that can cause a range of symptoms including pain, severe exhaustion, cognitive impairment, and post-exertional malaise, the worsening of symptoms after physical or mental activity. More...
27 Dec 2019
Image: A CyteFinder instrument is an automated six channel fluorescence microscopes that rapidly image slides and employ machine learning to identify rare cells (Photo courtesy of RareCyte)

Circulating Trophoblast-Based Noninvasive Prenatal Testing Are Feasible

 Circulating cells from the fetus or placenta in a pregnant woman’s blood, primarily trophoblasts and nucleated fetal red blood cells (fnRBCs), have long been appreciated as potential targets for noninvasive prenatal testing (NIPT) and diagnosis. More...
26 Dec 2019
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Image: Innate immune cells: heterozygous mutations of the RIPK1 caspase-8 cleavage site cause the autoinflammatory disease CRIA syndrome (Photo courtesy of Walter and Eliza Hall Institute)

New Human Autoinflammatory Disease Identified

 Autoinflammatory diseases are caused by abnormal activation of the innate immune system, leading to recurrent episodes of fever and inflammation that can damage vital organs. More...
24 Dec 2019
Image: The BD FACSAria III fluorescent activated cell sorter used to enumerate circulating progenitor cells (Photo courtesy of Becton, Dickinson and Company.

Circulating Progenitor Cell Traffic Reflects Blood Vessel Repair

 Identifying patients with otherwise stable coronary artery disease (CAD) who are high-risk and would benefit from more intense or invasive interventions is currently a major theme in cardiology studies. More...
18 Dec 2019
Image: Histological slide of the human herpes virus-6 showing infected cells, with inclusion bodies in both the nucleus and the cytoplasm. A new method has been developed to separate between two different types of a common herpes virus, and HHV-6 has been linked to multiple sclerosis (Photo courtesy of National Cancer Institute)

Multiple Sclerosis Linked to Variant of Common Herpes Virus

 Multiple sclerosis, MS, is an autoimmune disease that affects the central nervous system. The cause of the disease is unclear, but one plausible explanation is a virus deceives the immune system to attack the body's own tissue. More...
12 Dec 2019
Image: The ARCHITECT Anti-HCV assay is a fully automated high throughput chemiluminescent microparticle immunoassay (CMIA) for the detection of antibodies to structural and nonstructural proteins of the hepatitis C virus (HCV) (Photo courtesy of Abbot Diagnostics)

Diagnosis and Monitoring of Patients with Hepatitis C Virus

 The global prevalence of people with hepatitis C virus (HCV) antibodies (anti-HCV-positive) is estimated to be 115 million, and 80 million of them have an active infection (anti-HCV-positive and HCV-RNA-positive). More...
11 Dec 2019
Image: HbA1c Advanced Clinical Chemistry Diabetes Assay: to diagnose maturity-onset diabetes of the young (MODY), screening for at least three autoantibodies and HbA1c testing should takes place in all youth at the time of diabetes diagnosis (Photo courtesy of Beckman Coulter)

Three Factors Distinguish MODY, a Rare Diabetes, in Youth

 Identifying maturity-onset diabetes of the young (MODY) in pediatric populations close to diabetes diagnosis is difficult. Misdiagnosis and unnecessary insulin treatment are common. MODY is a monogenic, dominantly inherited form of diabetes that typically arises in adolescence or young adulthood, and accounts for 1%-4% of cases of pediatric diabetes. More...
10 Dec 2019
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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