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Immunology

Image: Sacroiliac joint biopsy specimen of a 29 year old male patient with ankylosing spondylitis. The biopsy specimen shows a subchondral cellular infiltrate partly invading the cartilage. Fibroblasts and activated lymphocytes are seen in the infiltrate. In between are areas of calcification and bone formation (Photo courtesy of Professor J. Braun).

Fibrinogen-Albumin Ratio Correlated to Ankylosing Spondylitis Disease Activity

 Ankylosing spondylitis (AS) is a systematic inflammatory autoimmune disease that primarily involves the spine and sacroiliac joints. Typically the joints where the spine joins the pelvis are also affected and occasionally other joints such as the shoulders or hips are involved. Back pain is a characteristic symptom of AS, and it often comes and goes. More...
23 Mar 2020
Image: The IMMULITE 2000 XPi system is easy to use and has one of the largest automated immunoassay menus available. Medium- to high-volume laboratories can incorporate specialty and allergy testing into routine workloads to improve productivity and efficiency (Photo courtesy of Siemens Healthineers).

Combining Biomarkers Predicts Metastasis in Medullary Thyroid Carcinoma

 Medullary thyroid carcinoma (MTC) is a neuroendocrine neoplasm originating from thyroid parafollicular C cells and accounts for only 5% of all thyroid cancers, but its malignancy is relatively high, causing 8% to 13% of thyroid cancer‐related deaths due to its aggressiveness. More...
18 Mar 2020
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Image: The Gallios flow cytometer provides efficient acquisition of superior quality data from up to 10 colors with advanced optical design for enhanced sensitivity for multicolor assays (Photo courtesy of Beckman Coulter).

Minimal Residual Disease Assessed in AL Amyloidosis Patients

 Amyloid light-chain (AL) amyloidosis, also known as primary amyloidosis, is the most common form of systemic amyloidosis in the USA. Despite achieving a hematologic complete response after treatment, many patients with AL amyloidosis do not attain recovery of organ function and/or experience hematologic relapse. More...
17 Mar 2020
Image: Electron micrograph of Coronaviruses which take their name from their crown-like halo (Photo courtesy of EYE OF SCIENCE/SPL).

Global Coronavirus Crisis: Researchers, Industry Mobilize to Offer Remedies (Updated)

In light of the worsening global Coronavirus health crisis, the In-Vitro Diagnostics sector around the world is racing to develop a definitive test for the COVID-19 virus. Several such assays are currently in the pipeline, and some are to be marketable within weeks. More...
09 Mar 2020
Image: PAX5/CD103 dual immunohistochemistry (IHC) staining showing no definite dual-positive cells, PAX5 stain showing brown nuclear staining in nonneoplastic B cells and CD103 showing membranous and cytoplasmic staining in a subset of T cells (Photo courtesy of US National Institute of Cancer).

Dual Immunohistochemistry Bone Marrow Staining Detects Hairy Cell Leukemia

 Hairy cell leukemia (HCL) is a B-cell lymphoproliferative disorder characterized by distinct immunophenotype (positive for CD19, CD20, PAX5, CD22, CD11c, CD25, CD103, CD123, and CD200). Immunophenotypic analysis by flow cytometry (FC) is considered the gold standard for diagnosis of HCL. More...
03 Mar 2020
Image: MACS Technology is a fast and gentle method for the isolation of viable and functionally active cells by magnetic labeling (Photo courtesy of University of Konstanz).

Fetal Cell-Based NIPT Demonstrated by Droplet Digital PCR

 Noninvasive testing techniques are often used for fetal diagnosis of genetic abnormalities, but are limited by certain characteristics, including non-informative results. Thus, novel methods of noninvasive definitive diagnosis of fetal genetic abnormalities are needed. More...
27 Feb 2020
Image: This photomicrograph depicts T cells interacting with each other. Cell surfaces are labeled in red, cell nuclei in blue, and receptors mediating communication in green (Photograph courtesy of Immunity).

T Cells Function as A Team to Fight Infection

 When faced with an infection, T cells normally follow a remarkably reproducible response pattern of expansion, contraction, and memory formation. Population-intrinsic and -extrinsic regulation of T cells occur, but are not mutually exclusive. More...
26 Feb 2020
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.
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