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Hematology

Image: Peripheral blood film from a newborn with hydrops fetalis; note the hypochromia, anisopoikilocytic changes, and erythroblastosis (Photo courtesy of Boston Medical Center).

Parental Screening Can Prevent Hydrops Fetalis in Fetus

Hydrops fetalis (fetal hydrops) is a serious fetal condition defined as abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema. More...
10 Jan 2018
Image: The Star Evolution coagulation analyzer (Photo courtesy of Diagnostica Stago).

Drug Causes Missed Diagnosis of Protein S Deficiency

Rivaroxaban is a direct, antithrombin-independent factor Xa inhibitor, which inhibits not only free factor Xa, but also clot-bound factor Xa and the prothrombinase complex. It is used for treatment and prevention of venous thromboembolism, as well as for prophylaxis of stroke in patients with atrial fibrillation. More...
01 Jan 2018
Image: On the left side of the diagram, the ABL gene from Chromosome 9 and the BCR gene from Chromosome 22 are combined together to make the ‘Philadelphia chromosome’. This chromosome has a small part at the top and a longer part of the bottom. The bottom part is labelled as a fusion gene, which is BCR and ABL combined (Photo courtesy of Macmillan Cancer Support).

Digital PCR Test Monitors CML Therapy Response

Chronic myeloid leukemia, or CML, is characterized by the "Philadelphia chromosome," a translocation of chromosomes 9 and 22 that results in the breakpoint cluster region protein- Abelson murine leukemia viral oncogene homolog 1(BCR-ABL) gene fusion. More...
28 Dec 2017
Image: A histopathology of a fatal sickle cell crisis which resulted from sickling within the vasa recta within the kidney. Glomeruli are occluded by sickle cells (Photo courtesy of Dr. Vishai Ramteke).

Biomarker of Kidney Disease Identified in Sickle Cell Anemia

In patients with sickle cell anemia (SCA), urinary ceruloplasmin (CP) may complement urinary free hemoglobin as a noninvasive biomarker for chronic kidney disease. Ceruloplasmin is a ferrioxidase that is important facilitator of cellular iron export by ferroportin and of iron binding by transferrin. More...
27 Dec 2017
Image: Bone marrow biopsy of a patient with multiple myeloma, showing diffuse infiltration by neoplastic plasma cells, which can be recognized by the eccentric nucleus and perinuclear halo (Photo courtesy of Dr. Michael G. Bayerl).

Multiple Myeloma Survival Associated with Enzyme Levels

Multiple myeloma (MM) is the second most common blood cancer in the USA and 30% to 50% of multiple myeloma patients have extra copies of the gene that encodes the enzyme Adenosine Deaminase, RNA Specific (ADAR1). More...
21 Dec 2017
Image: A scanning electron micrograph (SEM) of induced stem cells (Photo courtesy of University of New South Wales).

Harvesting Method Produces Superior Transplantation Stem Cells

Hematopoietic stem cell transplantation is a potential curative therapy for malignant and nonmalignant diseases. Improving the efficiency of stem cell collection and the quality of the cells acquired can broaden the donor pool and improve patient outcomes. More...
19 Dec 2017
Image: Peripheral bloods smear showing five eosinophils, from a patient with eosinophilia (Photo courtesy of the Hospital for Sick Children, Toronto).

Eosinophilic Biomarker Found for Aggressive IBD

Peripheral blood eosinophilia (PBE) in inflammatory bowel disease is associated with ulcerative colitis (UC) and active disease. Little data exist on the long-term impact of PBE on disease course. More...
14 Dec 2017
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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