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Molecular Diagnostics

Image: A diagram of the loss of an androgen-inactivating and isoform-specific HSD17B4 splice form enables emergence of castration-resistant prostate cancer (Photo courtesy of the Lerner Research Institute).

New Gene Variant Linked to Prostate Cancer

Prostate cancer (PCa) is the most commonly diagnosed malignancy and the second leading cause of cancer-related death in men in the USA. The growth and survival of PCa cells are driven by androgens through activation of the androgen receptor (AR) and its target genes. More...
30 Jan 2018
Image: CancerSEEK multi-analyte test simultaneously evaluates levels of eight cancer proteins and the presence of cancer gene mutations from circulating DNA in the blood (Photo courtesy of Elizabeth Cook and Kaitlin Lindsay, Johns Hopkins University).

Liquid Biopsy Test Detects Eight Types of Cancer

Cancer researchers have developed a "liquid biopsy" blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. More...
29 Jan 2018
Image: The pixelated spatial gene expression tool can analyze an entire tissue sample and identify cancer cells in a process that takes less than two hours (Photo courtesy of the University of Illinois).

Cancerous Tissue Analysis Introduced Using On-chip Technology

A novel gene expression analysis technique has been introduced that can accurately measure levels of RNA quickly and directly from a cancerous tissue sample while preserving the spatial information across the tissue. More...
29 Jan 2018
Image: The QX200 droplet digital polymerase chain reaction (ddPCR) system (Photo courtesy of Bio-Rad Laboratories).

KRAS Mutations Revealed in Rare Brain Condition

Sporadic arteriovenous malformations of the brain, which are morphologically abnormal connections between arteries and veins in the brain vasculature, are a leading cause of hemorrhagic stroke in young adults and children. More...
25 Jan 2018
Image: Human stomach adenocarcinoma stained with anti-myeloperoxidase (MPO) antibody (Photo courtesy of Roche Life Science).

Biomarkers Predict Prognosis in Alcohol-Related Cancer Patients

Alcohol consumption has been identified as a modifiable risk factor for cancers such as gastric cancer. Alcohol consumption likely induces gastric carcinogenesis through deregulation of ribonucleic acid polymerase III (POLR3) III and oxidative damage. More...
25 Jan 2018
Image: The Amnis ImageStreamX Mark II imaging flow cytometer (Photo courtesy of the University of Alabama at Birmingham).

Improved Blood Stabilization Used for CTC Profiling

A new blood stabilization method significantly prolongs the lifespan of blood samples for microfluidic sorting and transcriptome profiling of rare circulating tumor cells, living cancer cells carried in the bloodstream. More...
24 Jan 2018
Image: The Ion Torrent Proton next-generation sequencing system (Photo courtesy of Thermo Fisher Scientific).

Multi-Gene Test Predicts Early Heart Disease Risk

Heart disease is the leading cause of death, both in the United States and worldwide. The most common form is coronary artery disease, which occurs when the blood vessels to the heart narrow or harden. More...
24 Jan 2018
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