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Molecular Diagnostics

Image: The automated NanoString nCounter system provides a direct measurement of gene expression using a novel digital color-coded barcode technology (Photo courtesy of the Fred Hutchinson Cancer Research Center).

Elevated Mir-24-3p Plays Prognostic Role in Breast Cancer

Breast cancer is the most common malignancy in women. In 2018 an estimated 266,120 new cases of invasive breast cancer are expected to be diagnosed in women in the USA, along with 63,960 new cases of non-invasive breast cancer. Therefore, there is a need to identify novel prognostic and predictive markers of occult metastases to better individualize adjuvant systemic therapy. More...
12 Mar 2018
Image: A digitally colorized transmission electron micrograph (TEM) of Zika virus. Virus particles (colored blue) are 40 nanometers in diameter with an outer envelope and an inner dense core (Photo courtesy of the CDC).

Sensitive ELISA Detects ZIKV Infection before Onset of Symptoms

A latest generation immunoassay for Zika virus (ZIKV) infection should help in guiding clinical management of mothers at risk for potential exposure to ZIKV and enable insights into the epidemiology of ZIKV infections. More...
12 Mar 2018
Image: An illustration of the novel method for transporting biospecimens, which eliminates the current method using cold-chain transport (Photo courtesy of Washington University).

Novel Method Introduced for Dry Storage of Biological Samples

A novel method for preserving biological samples collected for diagnostic testing at room temperature may one day eliminate the need for refrigeration, which is often not available in third-world settings. More...
12 Mar 2018
Image: The microfluidic control instrument performing a Drop-seq run (Photo courtesy of the New York Genome Center).

Microfluidic Device Brings Single-Cell Technology to Bedside

The complex architecture and associated higher-order function of human tissues relies on functionally and molecularly diverse cell populations. Defining the cellular subsets found in pathologic tissues provides insights into disease etiology and treatment options. More...
06 Mar 2018
Image: A micrograph showing hypertrophic decidual vasculopathy, a finding seen in gestational hypertension and preeclampsia (Photo courtesy of Wikimedia Commons).

Genomic Findings May Lead to Blood Test for Preeclampsia

A genomics-based study revealed a panel of microRNAs that may eventually be used to diagnose preeclampsia, a dangerous complication occurring during pregnancy. More...
05 Mar 2018
Image: A Manhattan plot of the study results show taller peaks that denote genetic loci most significantly associated with pancreatic cancer risk (Photo courtesy of Dr. Alison Klein, Johns Hopkins University).

Large Genomic Study Identifies New Pancreatic Cancer Risk Loci

A large genome-wide association study (GWAS) identified five new susceptibility loci for pancreatic cancer. More...
05 Mar 2018
Image: The Oncotype-Dx 21-gene recurrence score for predicting risk for metastatic breast cancer has been quickly adopted in clinical practice, but which is currently going through consultation (Photo courtesy of Genomic Health).

Multigene Breast Cancer Recurrence Signatures Tests Compared

A comparison of commercially available multigene breast cancer recurrence signatures suggests that some tests may be better than others at assessing which patients are at risk for late distant recurrence, which could be impacting oncologists' ability to guide appropriate treatment decisions for patients. More...
03 Mar 2018
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.