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Molecular Diagnostics

Image: The Infinium Human Methylation 450K BeadChip: robust methylation profiling microarray with extensive coverage of CpG islands, genes, and enhancers; used for epigenome-wide association studies (Photo courtesy of Illumina).

DNA Methylation Linked to Depression in Middle-Aged and Elderly

More than 300 million people across the world suffer from depression, and while genetics contributes to depression risk, so do environmental factors such as adverse life events and stress, particularly among individuals who develop depression later in life. More...
03 Aug 2018
Image: The Sensiscript reverse transcription kit is ideally suited for highly sensitive applications using very small amounts of RNA (Photo courtesy of Qiagen).

New Target Protein for Colon Cancer Identified

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the third leading cause of cancer-related death in men and women in the USA. Pathogenic mediators that regulate CRC tumorigenesis are desirable biomarkers to predict prognosis, recurrence of the disease, and response to therapy to improve the management of patients with CRC. More...
02 Aug 2018
Image: The NextSeq 550Dx next-generation sequencing system (Photo courtesy of Illumina).

Neuro Disorders Involving Epilepsy Include Distinct De Novo Variants

Epilepsy is a central nervous system (neurological) disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behavior, sensations, and sometimes loss of awareness. More...
26 Jul 2018
Image: Genomic sequencing trajectory from the 1990s to the present (Photo courtesy of Mayo Clinic).

Sequencing Produces Better Diagnostics for Pediatric Genetic Disease

Currently, chromosomal microarrays are the recommended first-line genomic tests for children with certain genetic diseases, which can be difficult to diagnose. However, whole-genome and whole-exome sequencing have become more common testing approaches in recent years. More...
26 Jul 2018
Image: A malignant melanoma of the skin (Photo courtesy of National Cancer Institute).

Biomarker Detects Active Melanoma and Predicts Survival

Melanoma is the most dangerous form of skin cancer, these cancerous growths develop when unrepaired DNA damage to skin cells, which is most often caused by ultraviolet radiation from sunshine or tanning beds, triggers mutations (genetic defects) that lead the skin cells to multiply rapidly and form malignant tumors. More...
25 Jul 2018
Image: A blood smear from a patient with acute myeloid leukemia showing very large, immature myeloblasts with many nucleoli. A distinctive feature of these blasts is a linear red \"Auer rod\" composed of crystallized granules (Photo courtesy of University of Utah Medical School).

Acute Myeloid Leukemia Risk Predicted in Healthy Individuals

The incidence of acute myeloid leukemia (AML) increases with age and mortality exceeds 90% when diagnosed after age 65. Most cases arise without any detectable early symptoms and patients usually present with the acute complications of bone marrow failure. More...
25 Jul 2018
Image: An illustration of graphene-based single nucleotide polymorphism (SNP) detection chip wirelessly transmitting signal to a smartphone (Photo courtesy of Professor Ratnesh Lal, PhD).

Biosensor Chip Detects SNPs with Higher Sensitivity

A single nucleotide polymorphism (SNP) is the change in a single nucleotide base (A, C, G or T) in the DNA sequence and it is the most common type of genetic mutation. While most SNPs have no discernible effect on health, some are associated with increased risk of developing pathological conditions such as cancer, diabetes, heart disease, neurodegenerative disorders, autoimmune and inflammatory diseases. More...
24 Jul 2018
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.
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