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Molecular Diagnostics

Image: Abnormal accumulation of tau protein in neuronal cell bodies (arrow) and neuronal extensions (arrowhead) in the neocortex of a patient who had died with Alzheimer`s disease (Photo courtesy of Wikimedia Commons).

Phosphorylated Tau Protein Blood Test Distinguishes Alzheimer’s Disease from Other Neurological Disorders

A recently developed blood test has confirmed the hypothesis that elevated levels of circulating phosphorylated tau 181 (pTau181) protein correlate with Alzheimer's disease (AD) and distinguish it from other neurological disorders that may be misdiagnosed as AD. More...
04 May 2020
Image: A new test quickly detects SARS-CoV-2 (spheres) through binding to antibodies (Y-shapes) on a field-effect transistor (Photo courtesy of adapted from ACS Nano 2020, DOI: 10.1021/acsnano.0c02823).

Rapid Diagnostic Sensor Detects COVID-19 Directly from Swab Extracts

A team of South Korean researchers has developed a diagnostic tool for the rapid detection of coronavirus from swab samples with no preparation steps. More...
30 Apr 2020
Image: Electron microscope image of urinary extracellular vesicles (EVs) (Photo courtesy of Pekka Rappu, University of Turku).

Proteomic Analysis of Urinary Extracellular Vesicles for the Diagnosis of Prostate Cancer

A new method for diagnosis of prostate cancer relies on advanced proteomics-based analysis of extracellular vesicles isolated from urine samples. More...
30 Apr 2020
Image: This liquid biopsy blood test detects pancreatic cancer early before it metastasizes (Photo courtesy of University of Pennsylvania School of Medicine).

Liquid Biopsy Assay for the Early Detection of Pancreatic Cancer

A liquid biopsy assay for multiple biomarkers enables early detection of pancreatic cancer before it metastasizes and while there are still treatment options available. More...
29 Apr 2020
Image: The LightCycler 96 Instrument is a real-time PCR system for rapid cycling up to 96 samples (Photo courtesy of Roche Molecular Systems).

Scabies Detected by Molecular Methods in Skin Scrapings

Scabies caused by Sarcoptes scabiei mites, is a highly contagious parasitic disease characterized by intense itching which is aggravated at night. Infections by scabies mites result in various skin eruptions consisting of papules, nodules, vesicles, and excoriated eczematous lesions due to scratching. More...
29 Apr 2020
Image: The nanoString nCounter: This instrument provides a simple and cost-effective solution of direct digital quantification for multiplex analysis of up to 800 known RNA, DNA, or protein targets in one tube (Photo courtesy of the Crown Institute of Genomics).

Genetic Alterations Analyzed in Pediatric Low-Grade Glioma

Low grade gliomas are brain tumors that come from two different types of brain cells known as astrocytes and oligodendrocytes. They are classified as a grade 2 tumor making them the slowest growing type of glioma in adults. More...
28 Apr 2020
Image: Schematic Diagram of the Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer (Photo courtesy of MD Anderson Cancer Center).

Molecular Differences Discovered Among Ovarian Cancer Subgroups

Ovarian cancer is a highly diverse disease with a high rate of overall mortality. High-grade serous ovarian cancer (HGSC) is the most common and aggressive type of epithelial ovarian cancer, exhibiting high levels of tumor heterogeneity and variable clinical outcomes. More...
28 Apr 2020
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Genetic Testing channel of LabMedica brings the latest in molecular genetics, cytogenetics, and epigenetics, and methods from PCR to FISH, and more.