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Medica 2025
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Molecular Diagnostics

Image: Illumina microarrays are a robust system that allow investigators to find variants in simple nucleotide polymorphisms (SNPs). The microarrays are subsequently scanned in the iScan system (Photo courtesy of LABSERGEN LANGEBIO).

Genetic Risk Factors Found in Gestational Diabetes

 Gestational diabetes mellitus (GDM) is a common pregnancy complication affecting 6%–15% of pregnancies globally. Although the condition resolves after delivery in most cases, women with a history of GDM have a more than sevenfold increased risk of developing type 2 diabetes (T2D) compared with women with a normoglycemic pregnancy. More...
26 Feb 2020
Image: Intermediate magnification micrograph of a low malignant potential (LMP) mucinous ovarian tumor (Photo courtesy of Wikimedia Commons)

Combining IL-6 Measurement with a Standard Biomarker Panel Improves Diagnosis of Ovarian Cancer

 Addition of the inflammatory biomarker IL-6 (interleukin-6) to a standard panel of tumor markers was found to enchance immunodiagnosis of ovarian cancer. More...
26 Feb 2020
Image: The V-PLEX Proinflammatory Panel 1 Human Kit measures 10 cytokines that are important in inflammation response and immune system regulation as well as numerous other biological processes (Photo courtesy of Meso Scale Discovery).

Novel Blood Tests Predict Progression of Parkinson's Disease

 It is well established that the cumulative incidence of dementia associated with Parkinson’s disease (PD) is approaching 80% and individuals with PD are five to six times more likely to develop cognitive impairment than age-matched controls. More...
25 Feb 2020
Image: New research suggests the success of immunotherapy can be predicted before treatment is administered (Photo courtesy of Weizmann Institute of Science)

Elevated Levels of Certain Immunoproteosome Components Predict Potential Success of Checkpoint Inhibitor Therapy in Melanoma Patients

 Increased expression of two protein members of the “immunoproteosome” can serve as important biomarkers for stratifying melanoma patients for immune-checkpoint treatment. More...
25 Feb 2020
Image: Proteogenomic Characterization of Endometrial Carcinoma (Photo courtesy of the Clinical Proteomic Tumor Analysis Consortium).

Proteogenomic Characterization of Endometrial Carcinoma Analyzed

 Endometrial cancer is a cancer that arises from the endometrium which is the lining of the uterus or womb. It is the result of the abnormal growth of cells that have the ability to invade or spread to other parts of the body. More...
24 Feb 2020
Image: The level of uric acid in saliva is a good indicator of body fat percentage in a study designed to identify reliable biomarkers that can be used to develop quick non-invasive tests for early detection of chronic diseases ((Photo courtesy of Dr. Paula Midori Castelo, Federal University of São Paulo)

Uric Acid in Saliva Is a Biomarker for Body Fat Accumulation in Adolescents

 The noninvasive measurement of uric acid in saliva has been shown to be an important marker of body fat accumulation in adolescents, which demonstrates the clinical relevance of saliva for detection of early metabolic changes and monitoring of nutritional status. More...
24 Feb 2020
Image: Ceramide structure: R represents the alkyl portion of a fatty acid (Photo courtesy of Wikimedia Commons)

Ratio of Serum Very-long-chain to Long-chain Ceramides Is Predictive of Dementia Risk

 Results obtained by a large community-based study showed that the ratio of very long‐chain to long‐chain ceramides in the blood was associated with risk of developing various types of dementia including Alzheimer's disease (AD). More...
24 Feb 2020
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