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Molecular Diagnostics

Image: Micrograph of prostate adenocarcinoma, acinar type, the most common type of prostate cancer (Photo courtesy of Wikimedia Commons)

Methylome Analysis for Noninvasive Prostate Cancer Monitoring

 Researchers have demonstrated the potential of methylation analysis of circulating tumor DNA (ctDNA) for the noninvasive diagnosis of prostate cancer. More...
19 Mar 2020
Image: Micrograph showing a prostate cancer (conventional adenocarcinoma) with perineural invasion (Photo courtesy of Wikimedia Commons)

Advanced Urinary Analysis Method Expected to Significantly Reduce Number of Prostate Cancer Biopsies

 A team of British researchers has developed an advanced, RNA and DNA biomarker-based urine test for diagnosis of prostate cancer, which is expected to significantly reduce the number of unnecessary biopsies performed every year. More...
18 Mar 2020
Image: Schematic diagram of Neurofibromin as an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer (Photo courtesy of Baylor College of Medicine).

Neurofibromatosis Gene and Breast Cancer Resistance to Hormone Therapy

 The cells of estrogen receptor positive (ER+) breast cancer have receptors that allow them to use the hormone estrogen to grow. Treatment with anti-estrogen hormone (endocrine) therapy can block the growth of the cancer cells. More...
17 Mar 2020
Image: The MinION nanopore sequencer used for real-time microbial cell-free DNA analyses in septic patients (Photo courtesy of Fraunhofer Institute for Interfacial Engineering and Biotechnology)

Rapid Test Uses Nanopore Sequencing to Diagnose Sepsis by Detecting DNA Released by Pathogenic Microorganisms in the Bloodsteam

 A team of German researchers has developed a rapid test to diagnosis sepsis by detecting DNA released by pathogenic microorganisms in the bloodsteam. More...
17 Mar 2020
Image: Histopathology showing the key features of small cell lung carcinoma (SCLC): Nuclear molding; salt and pepper chromatin; and scant cytoplasm (Photo courtesy of Nephron).

Blood-Based MicroRNA Signatures Distinguishes Individuals with Lung Cancer

 The overall low survival rate of patients with lung cancer calls for improved detection tools to enable better treatment options and improved patient outcomes. Lung cancer affects about 228,000 people a year in the USA and has a five-year survival rate just shy of 20%. More...
16 Mar 2020
Image: The Oragene DNA saliva collection kit (Photo courtesy of DNA Genotek)

Methylated DNA in Saliva Samples Predicts Likelihood of Developing Childhood Obesity

 A study based on analysis of saliva samples supports the concept that determination of DNA methylation in salivary tissue can be used to predict the eventual development of obesity by Hispanic children. More...
16 Mar 2020
Image: The Direct-zol RNA Miniprep kit is an RNA purification kit that provides a streamlined method for the purification of up to 100 µg (per prep) of high-quality RNA directly from samples in TRI Reagent or similar (Photo courtesy of Zymo Research).

Noninvasive Urine Test Developed for Prostate Cancer

 It is estimated that 191,930 men will be diagnosed with prostate cancer (PCa) in USA this year, and 33,330 of these patients will die of the disease this year. PCa is one of the second most frequently diagnosed cancer deaths among men worldwide. More...
12 Mar 2020
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