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Molecular Diagnostics

Image: Abnormal accumulation of tau protein in neuronal cell bodies (arrow) and neuronal extensions (arrowhead) in the neocortex of a patient who had died with Alzheimer`s disease (Photo courtesy of Wikimedia Commons)

Circulating Levels of Phosphorylated Tau Protein Differentiate Alzheimer’s Disease from other Types of Dementia

 Elevated levels of circulating phosphorylated tau 181 (pTau181) protein correlate with Alzheimer's disease (AD) and distinguish it from frontotemporal dementia, a condition that is often misdiagnosed as AD. More...
10 Mar 2020
Image: The AmpFire Multiplex Human papillomavirus (HPV) assay for real time fluorescent detection (Photo courtesy of AtilaBiosystems).

High-Throughput Isothermal HPV Test Validated

 Human papillomavirus (HPV) is a viral infection that is passed between people through skin-to-skin contact. There are over 100 varieties of HPV, more than 40 of which are passed through sexual contact and can affect the genitals, mouth, or throat. More...
10 Mar 2020
Image: The Nextseq 500/550 High Output 75 cycle kit deliver powerful sequencing chemistries with as little as 10 minutes of hands-on time (Photo courtesy of Illumina).

Novel 3-Gene Transcriptional Signature Stratified for Tuberculosis Contacts

 The causative agent of tuberculosis, Mycobacterium tuberculosis (Mtb) is an obligate pathogen. The highest risk of tuberculosis arises in the first few months after exposure. Early treatment also offers the opportunity to adopt shorter and simpler treatment regimens, limit pathology, and reduce tuberculosis-associated morbidity. More...
04 Mar 2020
Image: Micrograph showing amyloid deposits. Amyloid shows up as homogeneous pink material in lamina propria and around blood vessels (Photo courtesy of Wikimedia Commons)

Increased Levels of Serum Amyloid-beta Linked to Development of Cardiovascular Disease

 A new review article has summarized studies, which suggest that the Alzheimer’s disease (AD) biomarker amyloid-beta (Abeta) has a causitive link to other age-related conditions such as cardiovascular disease (CVD). More...
04 Mar 2020
Image: The Variant II Turbo Hemoglobin Testing System combines High Performance Liquid Chromatography (HPLC) precise and variant detection with fast throughput to provide a comprehensive solution for HbA1c testing (Photo courtesy of Bio-Rad).

Monogenic Hypercholesterolemia Increases Cardiovascular Disease Risk

 Monogenic familial hypercholesterolemia (FH) is associated with lifelong elevations in low-density lipoprotein cholesterol (LDL-C) levels and increased risk of atherosclerotic cardiovascular disease (CVD). More...
03 Mar 2020
Image: Peripheral blood smear from a patient with myelodysplastic syndrome showing macrocytic and hyperchromic anemia (cross), hypersegmented neutrophil (arrow) and moderate thrombocytopenia (Photo courtesy of Jong-Hwa Kim, MD, PhD).

Leukemic Stem Cell Score Predicts Myelodysplastic Syndrome Prognosis

 Myelodysplastic syndromes (MDS) are clonal myeloid malignancies arising from hematopoietic stem cells (HSCs), which are characterized by bone marrow (BM) ineffective hematopoiesis, peripheral blood cytopenias, and a propensity to transform to acute myeloid leukemia (AML). More...
03 Mar 2020
Image: MicroRNA miR-122 secondary structure and sequence conservation (Photo courtesy of Wikimedia Commons)

Identification of a MicroRNA Biomarker Linked to a Childhood Liver Disease

 A study of infants and young children suffering from intestinal failure-associated liver disease found that levels of the microRNA biomarker miR-122 decreased following successful fish oil treatment. More...
03 Mar 2020
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