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Molecular Diagnostics

Image: The Nextseq 500/550 High Output 75 cycle kit deliver powerful sequencing chemistries with as little as 10 minutes of hands-on time (Photo courtesy of Illumina).

Novel 3-Gene Transcriptional Signature Stratified for Tuberculosis Contacts

 The causative agent of tuberculosis, Mycobacterium tuberculosis (Mtb) is an obligate pathogen. The highest risk of tuberculosis arises in the first few months after exposure. Early treatment also offers the opportunity to adopt shorter and simpler treatment regimens, limit pathology, and reduce tuberculosis-associated morbidity. More...
04 Mar 2020
Image: Micrograph showing amyloid deposits. Amyloid shows up as homogeneous pink material in lamina propria and around blood vessels (Photo courtesy of Wikimedia Commons)

Increased Levels of Serum Amyloid-beta Linked to Development of Cardiovascular Disease

 A new review article has summarized studies, which suggest that the Alzheimer’s disease (AD) biomarker amyloid-beta (Abeta) has a causitive link to other age-related conditions such as cardiovascular disease (CVD). More...
04 Mar 2020
Image: The Variant II Turbo Hemoglobin Testing System combines High Performance Liquid Chromatography (HPLC) precise and variant detection with fast throughput to provide a comprehensive solution for HbA1c testing (Photo courtesy of Bio-Rad).

Monogenic Hypercholesterolemia Increases Cardiovascular Disease Risk

 Monogenic familial hypercholesterolemia (FH) is associated with lifelong elevations in low-density lipoprotein cholesterol (LDL-C) levels and increased risk of atherosclerotic cardiovascular disease (CVD). More...
03 Mar 2020
Image: Peripheral blood smear from a patient with myelodysplastic syndrome showing macrocytic and hyperchromic anemia (cross), hypersegmented neutrophil (arrow) and moderate thrombocytopenia (Photo courtesy of Jong-Hwa Kim, MD, PhD).

Leukemic Stem Cell Score Predicts Myelodysplastic Syndrome Prognosis

 Myelodysplastic syndromes (MDS) are clonal myeloid malignancies arising from hematopoietic stem cells (HSCs), which are characterized by bone marrow (BM) ineffective hematopoiesis, peripheral blood cytopenias, and a propensity to transform to acute myeloid leukemia (AML). More...
03 Mar 2020
Image: MicroRNA miR-122 secondary structure and sequence conservation (Photo courtesy of Wikimedia Commons)

Identification of a MicroRNA Biomarker Linked to a Childhood Liver Disease

 A study of infants and young children suffering from intestinal failure-associated liver disease found that levels of the microRNA biomarker miR-122 decreased following successful fish oil treatment. More...
03 Mar 2020
Image: The ClearCell FX1 novel platform for detect circulating tumor DNA from blood samples (Photo courtesy of Explorea s.r.o.).

Heterogeneous Populations of Melanoma Circulating Tumor Cells Detected

 Circulating tumor cells (CTCs) can be assessed through a minimally invasive blood sample with potential utility as a predictive, prognostic and pharmacodynamic biomarker. The large heterogeneity of melanoma CTCs has hindered their detection and clinical application. More...
02 Mar 2020
Image: Photomicrograph of a pancreatic islet, showing insulin-producing beta cells (Photo courtesy of Wikimedia Commons)

Researchers Identify Genes Linked to the Development of Monogenic Diabetes

 By studying a well controlled group of young Lithuanian diabetes patients, researchers were able to identify genes linked to the development of the rare monogenic form of diabetes. More...
02 Mar 2020
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